Pulsatile Discharge from Polymeric Scaffolds: A Novel Method for Modulated Drug Release

DOI PDF 62 References
  • Patricia T Campana
    School of Arts, Sciences and Humanities, University of São Paulo (USP), Arlindo Bettio Av., 1000, São Paulo, 03828-000 , Brazil
  • Alexandre Marletta
    Institute of Physics, Federal University of Uberlândia (UFU), João Naves de Ávila Av., 2121, Uberlândia 38408-100 , Brazil
  • Kelliton J M Francisco
    School of Arts, Sciences and Humanities, University of São Paulo (USP), Arlindo Bettio Av., 1000, São Paulo, 03828-000 , Brazil
  • Francisco V R Neto
    Institute of Physics, Federal University of Uberlândia (UFU), João Naves de Ávila Av., 2121, Uberlândia 38408-100 , Brazil
  • Erick Piovesan
    Institute of Physics, Federal University of Uberlândia (UFU), João Naves de Ávila Av., 2121, Uberlândia 38408-100 , Brazil
  • Leandro Petrini
    School of Arts, Sciences and Humanities, University of São Paulo (USP), Arlindo Bettio Av., 1000, São Paulo, 03828-000 , Brazil
  • Danilo Machado
    Institute of Physics, Federal University of Uberlândia (UFU), João Naves de Ávila Av., 2121, Uberlândia 38408-100 , Brazil
  • Thiago R Silva
    School of Arts, Sciences and Humanities, University of São Paulo (USP), Arlindo Bettio Av., 1000, São Paulo, 03828-000 , Brazil
  • Francesco Basoli
    Department of Engineering, University of Rome “Campus Bio-Medico di Roma”, Alvaro del Portillo St., 21, Rome 00128 , Italy
  • Silvia Licoccia
    Department of Chemical Science and Technologies, University of Rome “Tor Vergata”, Via della Ricerca Scientifica St. Rome 00133 , Italy
  • Osvaldo N Oliveira
    Sao Carlos Institute of Physics, University of São Paulo (USP), CP 369, 13560-970, Sao Carlos, SP , Brazil
  • Enrico Traversa
    School of Materials and Energy, University of Electronic Science and Technology of China, 2006 Xiyuan Road, Chengdu 611731, Sichuan, P. R. China

Bibliographic Information

Published
2019-05-31
Rights Information
  • https://academic.oup.com/pages/standard-publication-reuse-rights
DOI
  • 10.1246/bcsj.20180403
Publisher
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>Controlled drug release holds promise to revolutionize medicine, particularly if short-term and long-term release can be combined in a single system. We present here a new pulsatile release system, in which the pulses were achieved using 3D scaffolds of poly(l-lactic acid), PLLA. From a morphological characterization of the scaffold’s surfaces, before and after releasing experiments at distinct pHs, we infer that release is governed by electrostatic interactions and the fractal geometry of the scaffolds. Furthermore, the scaffold can present short-term (within hours) or long-term (several days long) releasing profiles by varying the pH, which opens the way for unprecedented drug release control.</jats:p>

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