{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360846644032907904.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1246/bcsj.60.2163"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/bcsj/article-pdf/60/6/2163/55726007/bcsj.60.2163.pdf"}},{"identifier":{"@type":"NAID","@value":"130001982057"}}],"dc:title":[{"@value":"Kinetic Studies of Antioxidant Activity of New Tocopherol Model Compounds in Solution"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>The second-order rate constants ks for the reaction of 10 kinds of tocopherol (vitamin E) model compounds with stable phenoxyl radical in ethanol have been measured at 25.0°C, using a stopped-flow spectrophotometer, as a model reaction of tocopherols with unstable free radicals (ROO·, RO·, and HO·) in biological systems. The absolute ks values of α-, β-, γ-, and δ-tocopherol models are similar to or slightly smaller than those of the corresponding tocopherols having a long-phytyl-chain. The relative ks values (α: β: γ: δ=100 : 53 : 50 : 24), that is, relative antioxidant activities, of α-, β-, γ-, and δ-tocopherol models are in good agreement with those (100 : 44 : 47 : 20) of α-, β-, γ-, and δ-tocopherols. The antioxidant activities of tocopherol models having two alkyl substituents, such as methyl, ethyl, isopropyl, and t-butyl groups, at ortho positions of OH group are similar to each other, suggesting that the effect of steric hindrance on the reaction rate is small. 5,7-Dimethyltocol model has quite similar rate constants with those of β- and γ-tocopherol models, whereas δ-tocopherol model is only ca. 24% as reactive as α-tocopherol model and tocol model is only ca. 10% as reactive as α-tocopherol model. The result indicates that the rate constants increase as the total electron donating capacity of the alkyl substituents at aromatic ring increases. For the tocopherol models logks was found to correlate with Σσ+ substituent constants with a ρ+ value of −1.0.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1581980077665646339","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021899403"}],"foaf:name":[{"@value":"Kazuo Mukai"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Science, Ehime University"}]},{"@id":"https://cir.nii.ac.jp/crid/1581980077665646337","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021899405"}],"foaf:name":[{"@value":"Satoshi Yokoyama"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Science, Ehime University"}]},{"@id":"https://cir.nii.ac.jp/crid/1581980077665646336","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021899407"}],"foaf:name":[{"@value":"Kazuyuki Fukuda"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Science, Ehime University"}]},{"@id":"https://cir.nii.ac.jp/crid/1581980077665646338","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021899410"}],"foaf:name":[{"@value":"Yuichi Uemoto"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, Faculty of Science, Ehime University"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00092673"},{"@type":"EISSN","@value":"13480634"}],"prism:publicationName":[{"@value":"Bulletin of the Chemical Society of Japan"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"1987-06-01","prism:volume":"60","prism:number":"6","prism:startingPage":"2163","prism:endingPage":"2167"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/bcsj/article-pdf/60/6/2163/55726007/bcsj.60.2163.pdf"}],"createdAt":"2006-07-25","modifiedAt":"2024-01-18","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143767939200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Electron pin resonane of chromanoxy free radicals from α-, ζ2-, β-, γ-, δ-tocopherol and tocol"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694078706944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxidation of Lipids. IV. Formation and Reaction of Chromanoxyl Radicals as Studied by Electron Spin Resonance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618530836864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"THE INHIBITED AUTOXIDATION OF STYRENE: PART III. THE RELATIVE INHIBITING EFFICIENCIES OF ORTHO-ALKYL PHENOLS"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620896785024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"EPR spectra of some .alpha.-tocopherol model compounds. Polar and conformational effects and their relation to antioxidant activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169050548608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of a Flow-Injection ESR System for Evaluating the Lipophilic Alkoxyl Radical Eliminating Capacities (L-AREC) of Tocopherol Analogues and Unsaturated Fatty Acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846644032407680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preparation and ESR Studies of New Stable Tocopheroxyl Model Radicals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846644032742144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Optical Spectra of Tocopheroxyl Model Radicals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846644032756480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stopped-Flow Investigation of Antioxidant Activity of Tocopherols"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570539332864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antioxidant activity of vitamin E and related phenols. Importance of stereoelectronic factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520286351744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Über Sauerstoffradikale, XI. Das 4‐Phenyl‐2.6‐di‐tert.‐butyl‐phenoxyl‐(1)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994700578432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antioxidant activity of phenols related to vitamin E. Are there chain-breaking antioxidants better than .alpha.-tocopherol?"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470580153984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Electron nuclear double resonance studies of radicals produced by the PbO2 oxidation of α-tocopherol and its model compound in solution"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945363963520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418676751616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Electrophilic Substituent Constants"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419791968128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Electron spin resonance studies of chromanoxyl radicals derived from tocopherols"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369280333440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis of Methyl Substituted 6-Hydroxychromans, Model Compounds of Tocopherols."}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846155064704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846162056704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Electron spin resonance spectra of the chromanoxyl radicals derived from tocopherols (vitamin E) and their related compounds"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793334687104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antioxidative effect of α-tocopherol incorporation into lecithin liposomes on ascorbic acid-Fe2+-induced lipid peroxidation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204121898752","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis and Antioxidant Activity of 4<i>H</i>-1,3-Benzodioxin-6-ol Derivatives: New Vitamin E Analogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204122182528","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"X-Ray Crystallographic Studies of Vitamin E Derivatives. 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