{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360846644354535552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.pone.0062776"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.pone.0062776"}},{"identifier":{"@type":"PMID","@value":"23638144"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Neuroanatomical Evidence That Kisspeptin Directly Regulates Isotocin and Vasotocin Neurons"}],"description":[{"notation":[{"@value":"Neuropeptide kisspeptin has been suggested to be an essential central regulator of reproduction in response to changes in serum gonadal steroid concentrations. However, in spite of wide kisspeptin receptor distribution in the brain, especially in the preoptic area and hypothalamus, the research focus has mostly been confined to the kisspeptin regulation on GnRH neurons. Here, by using medaka whose kisspeptin (kiss1) neurons have been clearly demonstrated to be regulated by sex steroids, we analyzed the anatomical distribution of kisspeptin receptors Gpr54-1 and Gpr54-2. Because the both receptors were shown to be activated by kisspeptins (Kiss1 and Kiss2), we analyzed the anatomical distribution of the both receptors by in situ hybridization. They were mainly expressed in the ventral telencephalon, preoptic area, and hypothalamus, which have been suggested to be involved in homeostatic functions including reproduction. First, we found gpr54-2 mRNA expression in nucleus preopticus pars magnocellularis and demonstrated that vasotocin and isotocin (Vasopressin and Oxytocin ortholog, respectively) neurons express gpr54-2 by dual in situ hybridization. Given that kisspeptin administration increases serum oxytocin and vasopressin concentration in mammals, the present finding are likely to be vertebrate-wide phenomenon, although direct regulation has not yet been demonstrated in mammals. We then analyzed co-expression of kisspeptin receptors in three types of GnRH neurons. It was clearly demonstrated that gpr54-expressing cells were located adjacent to GnRH1 neurons, although they were not GnRH1 neurons themselves. In contrast, there was no gpr54-expressing cell in the vicinities of neuromodulatory GnRH2 or GnRH3 neurons. From these results, we suggest that medaka kisspeptin neurons directly regulate some behavioral and neuroendocrine functions via vasotocin/isotocin neurons, whereas they do not regulate hypophysiotropic GnRH1 neurons at least in a direct manner. Thus, direct kisspeptin regulation of GnRH1 neurons proposed in mammals may not be the universal feature of vertebrate kisspeptin system in general."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326233115520","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50634284"},{"@type":"NRID","@value":"1000050634284"},{"@type":"NRID","@value":"9000412300425"},{"@type":"NRID","@value":"9000014286256"},{"@type":"NRID","@value":"9000258075908"},{"@type":"NRID","@value":"9000325831327"},{"@type":"NRID","@value":"9000283623156"},{"@type":"NRID","@value":"9000021849279"},{"@type":"NRID","@value":"9000021826455"},{"@type":"NRID","@value":"9000253393406"},{"@type":"NRID","@value":"9000253393626"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/shinjikanda"}],"foaf:name":[{"@value":"Shinji Kanda"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276174851328","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50302807"},{"@type":"NRID","@value":"1000050302807"},{"@type":"NRID","@value":"9000016911553"}],"foaf:name":[{"@value":"Yasuhisa Akazome"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003447783243776","@type":"Researcher","foaf:name":[{"@value":"Yuta Mitani"}]},{"@id":"https://cir.nii.ac.jp/crid/1380003447783243778","@type":"Researcher","foaf:name":[{"@value":"Kataaki Okubo"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801200143872","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70143360"},{"@type":"NRID","@value":"1000070143360"},{"@type":"CINII_AUTHOR_ID","@value":"DA10754460"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA10754460#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA10754460"},{"@type":"NRID","@value":"9000019090429"},{"@type":"NRID","@value":"9000364657806"},{"@type":"NRID","@value":"9000002738902"},{"@type":"NRID","@value":"9000386095860"},{"@type":"NRID","@value":"9000364748596"},{"@type":"NRID","@value":"9000364720732"},{"@type":"NRID","@value":"9000364729058"},{"@type":"NRID","@value":"9000364732577"},{"@type":"NRID","@value":"9000015270800"},{"@type":"NRID","@value":"9000412422044"},{"@type":"NRID","@value":"9000364724205"},{"@type":"NRID","@value":"9000364733464"},{"@type":"NRID","@value":"9000011117418"},{"@type":"NRID","@value":"9000000130466"},{"@type":"NRID","@value":"9000410309693"},{"@type":"NRID","@value":"9000010606790"},{"@type":"NRID","@value":"9000364683615"},{"@type":"NRID","@value":"9000402131095"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0007804"}],"foaf:name":[{"@value":"Yoshitaka Oka"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380003447783243779","@type":"Researcher","foaf:name":[{"@value":"Hubert Vaudry"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"19326203"}],"prism:publicationName":[{"@value":"PLoS ONE"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2013-04-25","prism:volume":"8","prism:number":"4","prism:startingPage":"e62776"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.pone.0062776"}],"createdAt":"2013-04-25","modifiedAt":"2019-07-12","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Kisspeptins","dc:title":"Kisspeptins"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Brain","dc:title":"Brain"},{"@id":"https://cir.nii.ac.jp/all?q=Oxytocin","dc:title":"Oxytocin"},{"@id":"https://cir.nii.ac.jp/all?q=Gonadotropin-Releasing%20Hormone","dc:title":"Gonadotropin-Releasing Hormone"},{"@id":"https://cir.nii.ac.jp/all?q=Neuroanatomy","dc:title":"Neuroanatomy"},{"@id":"https://cir.nii.ac.jp/all?q=Vasotocin","dc:title":"Vasotocin"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Situ%20Hybridization","dc:title":"In Situ Hybridization"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782232694912","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24870007"},{"@type":"JGN","@value":"JP24870007"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24870007/"}],"notation":[{"@language":"ja","@value":"キスペプチン神経系による生殖と生殖行動の協調的制御機構の探索"},{"@language":"en","@value":"Investigation on coordinate regulation of reproduction and related behaviors by kisspeptin neuronal system"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257007560704","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20247005"},{"@type":"JGN","@value":"JP20247005"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20247005/"}],"notation":[{"@language":"ja","@value":"多機能性ＧｎＲＨペプチド神経系の生物機能に関する統合的研究"},{"@language":"en","@value":"Multidisciplinary studies on the biological functions of GnRH peptidergic neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257187236096","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24570067"},{"@type":"JGN","@value":"JP24570067"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24570067/"}],"notation":[{"@language":"ja","@value":"キスペプチンをはじめとする脳内ペプチドによる生殖中枢制御機構の解明"},{"@language":"en","@value":"Central regulatory system of reproduction by neuropeptides including kisspeptin."}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257198300928","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24657050"},{"@type":"JGN","@value":"JP24657050"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24657050/"}],"notation":[{"@language":"ja","@value":"脳内ペプチド遺伝子パラログにおける機能代償のＺＦＮ法を用いた実証"},{"@language":"en","@value":"Experimental demonstration of functional compensation among paralogous genes encoding neuropeptides"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218198599168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Three Types of Gonadotrophin‐Releasing Hormone Neurones and Steroid‐Sensitive Sexually Dimorphic Kisspeptin Neurones in Teleosts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218338767488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression of isotocin is male‐specifically up‐regulated by gonadal androgen in the medaka brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232024184192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Kisspeptin-10 potentiates miniature excitatory postsynaptic currents in the rat supraoptic nucleus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232559045120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Social rank-dependent expression of gonadotropin-releasing hormones and kisspeptin in the medaka brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235477163648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of synthetic kisspeptin peptides and GnRH analogue on oocyte growth and circulating sex steroids in prepubertal female chub mackerel (<i>Scomber japonicus</i>)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236938403584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Kiss1 Neurons Drastically Change Their Firing Activity in Accordance With the Reproductive State: Insights From a Seasonal Breeder"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005518374428928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gene knockout analysis reveals essentiality of estrogen receptor β1 (Esr2a) for female reproduction in medaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144830524288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nonapeptide mechanisms of social cognition, behavior and species-specific social systems"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168793302144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Estrogen upregulates the firing activity of hypothalamic gonadotropin‐releasing hormone (GnRH1) neurons in the evening in female medaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1360014183399915520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Developmental aspects of the hypothalamic-pituitary network related to reproduction in teleost fish"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016978716282624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Kisspeptin Exhibits Stimulatory Effects on Expression of the Genes for Kisspeptin Receptor, GnRH1 and GTH Subunits in a Gonadal Stage-Dependent Manner in the Grass Puffer, a Semilunar-Synchronized Spawner"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390753914112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of the kisspeptin system in regulation of sexual behaviors in medaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691067746432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Functional analysis of kisspeptin peptides in adult immature chub mackerel (Scomber japonicus) using an intracerebroventricular administration method"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691176906752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential regulation of the luteinizing hormone genes in teleosts and tetrapods due to their distinct genomic environments – Insights into gonadotropin beta subunit evolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693175368320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Steroid Sensitive <i>kiss2</i> Neurones in the Goldfish: Evolutionary Insights into the Duplicate Kisspeptin Gene‐Expressing Neurones"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694041402112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of KiSS-1 Product Kisspeptin and Steroid-Sensitive Sexually Dimorphic Kisspeptin Neurons in Medaka (Oryzias latipes)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707535746304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Temperature affects sexual maturation through the control of kisspeptin, kisspeptin receptor, GnRH and GTH subunit gene expression in the grass puffer during the spawning season"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710520410240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional and evolutionary insights into vertebrate kisspeptin systems from studies of fish brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710760494720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diurnal and Circadian Oscillations in Expression of Kisspeptin, Kisspeptin Receptor and Gonadotrophin‐Releasing Hormone 2 Genes in the Grass Puffer, A Semilunar‐Synchronised Spawner"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711915661056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Morphological Analysis of the Axonal Projections of EGFP-Labeled Esr1-Expressing Neurons in Transgenic Female Medaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286992336931840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolution of the regulatory mechanisms for the hypothalamic-pituitary-gonadal axis in vertebrates–hypothesis from a comparative view"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619712234240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Emerging Functions Of Gonadotropin‐Releasing Hormone II in Mammalian Physiology and Behaviour"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619721568640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643854648832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Multiple gonadotropin‐releasing hormone systems in non‐mammalian vertebrates: Ontogeny, anatomy, and physiology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166153679232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression changes of mRNAs encoding kisspeptins and their receptors and gonadotropin-releasing hormones during early development and gonadal sex differentiation periods in the brain of chub mackerel (Scomber japonicus)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168292155136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mapping of Kisspeptin Receptor <scp>mRNA</scp> in the Whole Rat Brain and its Co‐Localisation with Oxytocin in the Paraventricular Nucleus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169018271616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Time-of-Day-Dependent Changes in GnRH1 Neuronal Activities and Gonadotropin mRNA Expression in a Daily Spawning Fish, Medaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169018417152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolution of the Hypothalamic-Pituitary-Gonadal Axis Regulation in Vertebrates Revealed by Knockout Medaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169018464640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"High-Frequency Firing Activity of GnRH1 Neurons in Female Medaka Induces the Release of GnRH1 Peptide From Their Nerve Terminals in the Pituitary"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182351869824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sex differences in the expression of vasotocin/isotocin, gonadotropin-releasing hormone, and tyrosine and tryptophan hydroxylase family genes in the medaka brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182512425856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Discovery of conventional prolactin from the holocephalan elephant fish, Callorhinchus milii"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182512496000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Periodic regulation of expression of genes for kisspeptin, gonadotropin-inhibitory hormone and their receptors in the grass puffer: Implications in seasonal, daily and lunar rhythms of reproduction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186890697472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regular Pacemaker Activity Characterizes Gonadotropin-Releasing Hormone 2 Neurons Recorded from Green Fluorescent Protein-Transgenic Medaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092749655168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression dynamics of the genes for the hypothalamo-pituitary-gonadal axis in tiger puffer (Takifugu rubripes) at different reproductive stages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096068265472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580230607814784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Anomalous Temperature Interdicts the Reproductive Activity in Fish: Neuroendocrine Mechanisms of Reproductive Function in Response to Water Temperature"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588381061875328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neuromodulation in the fish brain for reproductive success"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661869080448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolutionally Conserved Function of Kisspeptin Neuronal System Is Nonreproductive Regulation as Revealed by Nonmammalian Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664363179264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evolutionary Insights into the Steroid Sensitive kiss1 and kiss2 Neurons in the Vertebrate Brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569798439296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural and functional multiplicity of the kisspeptin/GPR54 system in goldfish (Carassius auratus)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570807175168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential and Gonad Stage-Dependent Roles of Kisspeptin1 and Kisspeptin2 in Reproduction in the Modern Teleosts, Morone Species1"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045925631744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structural and functional evolution of gonadotropin‐releasing hormone in vertebrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046050708864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519758476544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hypogonadotropic hypogonadism in mice lacking a functional\n                    <i>Kiss1</i>\n                    gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994495216128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kisspeptin Acts Directly and Indirectly to Increase Gonadotropin-Releasing Hormone Neuron Activity and Its Effects Are Modulated by Estradiol"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994698862336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994820438016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cloning and Expression of kiss2 in the Zebrafish and Medaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995939487488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nonapeptides and Social Behavior in Fishes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468818200832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kisspeptin Increases γ-Aminobutyric Acidergic and Glutamatergic Transmission Directly to Gonadotropin-Releasing Hormone Neurons in an Estradiol-Dependent Manner"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471114804864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kisspeptin Activation of Supraoptic Nucleus Neurons in Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471221274240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Habenular Kiss1 Neurons Modulate the Serotonergic System in the Brain of Zebrafish"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943575398016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A role for central vasopressin in pair bonding in monogamous prairie voles"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944449575936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The\n                    <i>GPR54</i>\n                    Gene as a Regulator of Puberty"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945549935488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kisspeptin Signaling in the Brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419069541248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuropeptide regulation of social behavior in a monogamous cichlid fish"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893467037568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Telencephalic and preoptic areas integrate sexual behavior in hime salmon (landlocked red salmon, Oncorhynchus nerka): Results of electrical brain stimulation experiments"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895001989120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Involvement of the telencephalic hemispheres and the preoptic area in sexual behavior of the male goldfish, Carassius auratus: a brain-lesion study"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895305774336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Terminal nerve damage impairs the mating behavior of the male hamster"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895528911104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in Vertebrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369293262976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sex and seasonal co-variation of arginine vasotocin (AVT) and gonadotropin-releasing hormone (GnRH) neurons in the brain of the halfspotted goby"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370816308864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371143908480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular Identification and Functional Characterization of the Kisspeptin/Kisspeptin Receptor System in Lower Vertebrates1"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843738232960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843933608320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Organization of Two Independent Kisspeptin Systems Derived from Evolutionary-Ancient Kiss Genes in the Brain of Zebrafish"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844213927168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gonadotropin-Releasing Hormone-II Messenger Ribonucleic Acid and Protein Content in the Mammalian Brain Are Modulated by Food Intake"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845494295936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of arginine vasotocin in distinct preoptic regions is associated with dominant and subordinate behaviour in an African cichlid fish"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319574964096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Kisspeptin1 on Electrical Activity of an Extrahypothalamic Population of Gonadotropin-Releasing Hormone Neurons in Medaka (Oryzias latipes)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319643784704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kiss1\n          −/− Mice Exhibit More Variable Hypogonadism than Gpr54−/− Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319661317504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Central Administration of Kisspeptin-10 Inhibits Water and Sodium Excretion of Anesthetized Male Rats and the Involvement of Arginine Vasopressin"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319872314240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Critical Role for the Evolutionarily Conserved Gonadotropin-Releasing Hormone II: Mediation of Energy Status and Female Sexual Behavior"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670321026451840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Social status regulates kisspeptin receptor mRNA in the brain of Astatotilapia burtoni"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794660070016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795181543680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kisspeptin Depolarizes Gonadotropin-Releasing Hormone Neurons through Activation of TRPC-Like Cationic Channels"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270047286528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270307038848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Kisspeptin Excites Gonadotropin-Releasing Hormone Neurons through a Phospholipase C/Calcium-Dependent Pathway Regulating Multiple Ion Channels"}]},{"@id":"https://cir.nii.ac.jp/crid/1370846644354535555","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular Coevolution of Neuropeptides Gonadotropin-Releasing Hormone and Kisspeptin with their Cognate G Protein-Coupled Receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205292911872","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"マサバの生殖におけるキスペプチンシステムに関する研究"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288037025280","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"性行動に重要なKiss1神経系とその神経回路の解析"}]},{"@id":"https://cir.nii.ac.jp/crid/1390296265975521920","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparative reproductive physiology of commercial fish: Development of breeding experimental system and its applications"},{"@language":"ja","@value":"有用魚類の比較生殖生理学：飼育実験系の構築とその応用"}]},{"@id":"https://cir.nii.ac.jp/crid/1390577386781066112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Neuroendocrine regulation of reproduction by GnRH neurons: multidisciplinary studies using a small fish brain model"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1371/journal.pone.0062776"},{"@type":"KAKEN","@value":"PRODUCT-14898392"},{"@type":"KAKEN","@value":"PRODUCT-14898433"},{"@type":"KAKEN","@value":"PRODUCT-14898415"},{"@type":"KAKEN","@value":"PRODUCT-11978614"},{"@type":"KAKEN","@value":"PRODUCT-11978410"},{"@type":"KAKEN","@value":"PRODUCT-14672109"},{"@type":"KAKEN","@value":"PRODUCT-14773969"},{"@type":"KAKEN","@value":"PRODUCT-14773944"},{"@type":"OPENAIRE","@value":"doi_dedup___::a847305f2f8354e5c87a657fd6dde408"},{"@type":"CROSSREF","@value":"10.1111/jne.12545_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1111/are.12342_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1210/en.2014-1472_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1038/s41598-019-45373-y_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.ygcen.2018.11.014_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1111/jne.13101_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.yfrne.2021.100948_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.2331/suisan.wa3042_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.isci.2024.108971_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1111/jne.12165_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1210/en.2017-00873_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1111/jne.13068_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1111/jne.12356_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1210/en.2016-1356_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1210/en.2017-00289_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.ygcen.2020.113660_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.3389/fphys.2022.902257_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.ygcen.2024.114658_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1210/en.2017-00808_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.neulet.2013.12.072_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.brainres.2014.08.020_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.5983/nl2008jsce.44.87_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1507/endocrj.ej22-0669_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.3389/fendo.2022.917258_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.ygcen.2016.11.012_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.ygcen.2017.03.001_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.ygcen.2014.09.019_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.ygcen.2018.04.006_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.5983/nl2008jsce.41.75_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"},{"@type":"CROSSREF","@value":"10.1016/j.ygcen.2015.08.020_references_DOI_VrJnMGJ7u4JZAxKdShpOgdCmM2D"}]}