{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848655001050368.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/cne.22616"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcne.22616"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/cne.22616"}},{"identifier":{"@type":"PMID","@value":"21452229"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Reelin inhibits migration of sympathetic preganglionic neurons in the spinal cord of the chick"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The present study examined the effects of Reelin in the migration of sympathetic preganglionic neurons (SPN) in the spinal cord of the chick. SPN in the chick first migrate from the neuroepithelium to the ventrolateral spinal cord. They then undergo a secondary migration to cluster adjacent to the central canal, forming the column of Terni (CT). During secondary migration, abundant Reelin is found in large areas of the ventral spinal cord; the only areas devoid of Reelin are areas occupied by SPN or somatic motor neurons and the pathway along which SPN migrate. Ectopic expression of Reelin in the pathway of SPN through electroporation of full‐length Reelin DNA stopped SPN migration toward their destination. The spatiotemporal pattern of Reelin expression, along with the inhibition of SPN migration by exogenous Reelin, suggests that Reelin functions as a barrier to SPN migration during normal development of the spinal cord. J. Comp. Neurol. 519:1970–1978, 2011. © 2011 Wiley‐Liss, Inc.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848655001050116","@type":"Researcher","foaf:name":[{"@value":"Yee Ping Yip"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655001050386","@type":"Researcher","foaf:name":[{"@value":"Guangdou Zhou"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579922195162115","@type":"Researcher","foaf:name":[{"@value":"Ken‐Ichiro Kubo"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751167030144","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90280734"},{"@type":"NRID","@value":"1000090280734"},{"@type":"NDL_AUTHOR_ID","@value":"00941626"},{"@type":"NRID","@value":"9000011100690"},{"@type":"NRID","@value":"9000004601404"},{"@type":"NRID","@value":"9000000410448"},{"@type":"NRID","@value":"9000283525925"},{"@type":"NRID","@value":"9000001890999"},{"@type":"NRID","@value":"9000002109839"},{"@type":"NRID","@value":"9000238158322"},{"@type":"NRID","@value":"9000242104225"},{"@type":"NRID","@value":"9000018488016"},{"@type":"NRID","@value":"9000345307285"},{"@type":"NRID","@value":"9000254053464"},{"@type":"NRID","@value":"9000254442428"},{"@type":"NRID","@value":"9000342803074"},{"@type":"NRID","@value":"9000002477645"},{"@type":"NRID","@value":"9000258212019"},{"@type":"NRID","@value":"9000018382707"},{"@type":"NRID","@value":"9000412190318"},{"@type":"NRID","@value":"9000015234792"},{"@type":"NRID","@value":"9000020541388"},{"@type":"NRID","@value":"9000014138426"},{"@type":"NRID","@value":"9000004974645"},{"@type":"NRID","@value":"9000384356261"},{"@type":"NRID","@value":"9000405890712"},{"@type":"NRID","@value":"9000242107445"},{"@type":"NRID","@value":"9000254053195"},{"@type":"NRID","@value":"9000254443140"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kazunorinakajima"}],"foaf:name":[{"@value":"Kazunori Nakajima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655001050510","@type":"Researcher","foaf:name":[{"@value":"Joseph W. Yip"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219967"},{"@type":"EISSN","@value":"10969861"}],"prism:publicationName":[{"@value":"Journal of Comparative Neurology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2011-05-23","prism:volume":"519","prism:number":"10","prism:startingPage":"1970","prism:endingPage":"1978"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcne.22616"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/cne.22616"}],"createdAt":"2011-02-26","modifiedAt":"2023-11-21","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=General%20Neuroscience","dc:title":"General Neuroscience"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782085894144","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21591425"},{"@type":"JGN","@value":"JP21591425"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591425/"}],"notation":[{"@language":"ja","@value":"超早産児の神経学的後遺症としての高次脳機能障害についての病態研究"},{"@language":"en","@value":"Pathological study of higher brain dysfunction as a neurological outcome in extremely preterm infants"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257078777600","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22111001"},{"@type":"JGN","@value":"JP22111001"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-22111001/"}],"notation":[{"@language":"ja","@value":"動く細胞と場のクロストークによる秩序の生成"},{"@language":"en","@value":"Cross-talk between moving cells and microenvironment as a basis of emerging order in multicellular system"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257080902272","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22240041"},{"@type":"JGN","@value":"JP22240041"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22240041/"}],"notation":[{"@language":"ja","@value":"中枢神経系における神経細胞社会の構築機構"},{"@language":"en","@value":"Mechanisms of the development of neuronal cell community in the central nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257156176000","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23700417"},{"@type":"JGN","@value":"JP23700417"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700417/"}],"notation":[{"@language":"ja","@value":"大脳皮質形成を制御する分子メカニズムの解明"},{"@language":"en","@value":"The analyses of molecular mechanisms that regulate brain cortical development"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143871560960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role for Reelin in the Development of Granule Cell Dispersion in Temporal Lobe Epilepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145058350976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin Is a Secreted Glycoprotein Recognized by the CR-50 Monoclonal Antibody"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145357509376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular functions of the Rap1 GTP-binding protein: a pattern emerges"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145811062784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618523036800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Rescue of Ataxia and Preplate Splitting by Ectopic Expression of Reelin in reeler Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619096428160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Migratory pathway of sympathetic preganglionic neurons in normal and <i>reeler</i> mutant mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620381980800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620713220608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A panel of monoclonal antibodies against reelin, the extracellular matrix protein defective in reeler mutant mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169623557760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ectopic Reelin Induces Neuronal Aggregation with a Normal Birthdate-Dependent “Inside-Out” Alignment in the Developing Neocortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094045228928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A mechanism for inside-out lamination in the neocortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094384716416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A novel intermediate filament-associated protein, NAPA-73, that binds to different filament types at different stages of nervous system development."}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094659595776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096379332992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A series of normal stages in the development of the chick embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096407605888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cortical development: View from neurological mutants two decades later"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845538967998080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568627821312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A primer on using in ovo electroporation to analyze gene function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569258254848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569403274496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Specific projections of sympathetic preganglionic neurons are not intrinsically determined by segmental origins of their cell bodies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569686648704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569738249088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Obstructed neuronal migration along radial glial fibers in the neocortex of the reeler mouse: A golgi-EM analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045590900992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Introduction of DNA into Chick Embryos by in Ovo Electroporation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520259450880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994141553536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dual role of Cajal-Retzius cells and reelin in cortical development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994253689856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin Binds α3β1 Integrin and Inhibits Neuronal Migration"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994663216256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Linking Rap to cell adhesion"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995346884096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Efficient selection for high-expression transfectants with a novel eukaryotic vector"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468327440640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of a Dab1/CrkL/C3G/Rap1 Pathway in Reelin-Stimulated Neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469853192576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early appearance in neural crest and crest-derived cells of an antigenic determinant present in avian neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470955418240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vivo electroporation: a new frontier for gene delivery and embryology"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471473048448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regional and Cellular Patterns of<i>reelin</i>mRNA Expression in the Forebrain of the Developing and Adult Mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943521821312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin/Dab1 Signaling in the Developing Cerebral Cortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943656245760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The disabled 1 gene is disrupted by a replacement with L1 fragment in yotari mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943942509440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin controls position of autonomic neurons in the spinal cord"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945134028032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin Deficiency and Displacement of Mature Neurons, But Not Neurogenesis, Underlie the Formation of Granule Cell Dispersion in the Epileptic Hippocampus"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946217936384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418324024576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The reeler gene-associated antigen on cajal-retzius neurons is a crucial molecule for laminar organization of cortical neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418701079680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ectopic expression of reelin alters migration of sympathetic preganglionic neurons in the spinal cord"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419474385792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of the Reelin Signaling Pathway in Central Nervous System Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420340603904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development and migration of avian sympathetic preganglionic neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893929024640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin mRNA Expression During Mouse Brain Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895129120512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Retrohippocampal, hippocampal and related structures of the forebrain in the reeler mutant mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369169175936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Absence of Fyn and Src Causes a Reeler-Like Phenotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369455282432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GFRα1 Is Required for Development of Distinct Subpopulations of Motoneuron"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369894246144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A protein related to extracellular matrix proteins deleted in the mouse mutant reeler"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843540386560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Labeled lines in the retinotectal system: Markers for retinorecipient sublaminae and the retinal ganglion cell subsets that innervate them"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844771279232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Two new mutants, ‘trembler’ and ‘reeler’, with neurological actions in the house mouse (Mus musculus L.)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845134204928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318224921984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Migration of sympathetic preganglionic neurons in the spinal cord is regulated by reelin‐dependent Dab1 tyrosine phosphorylation and CrkL"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320443248128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/Reelin"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320648553728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Two modes of radial migration in early development of the cerebral cortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320788250880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin and brain development"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793689497344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unscrambling a disabled brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794022780288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mouse disabled (mDab1): a Src binding protein implicated in neuronal development"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794605386752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of Purkinje Cell Alignment by Reelin as Revealed with CR-50 Antibody"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795214741376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795694367616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reelin is a detachment signal in tangential chain-migration during postnatal neurogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269088273536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Changes in fibronectin distribution in the developing peripheral nervous system of the chick"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269191567232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Components of the Reelin signaling pathway are expressed in the spinal cord"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269701753856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The origin and development of the visceral in the spinal cord of the chick embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269753247488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270099719808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipoprotein Receptors in the Nervous System"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233271242190208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disruption of hippocampal development\n            <i>in vivo</i>\n            by CR-50 mAb against Reelin"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/cne.22616"},{"@type":"KAKEN","@value":"PRODUCT-12931256"},{"@type":"KAKEN","@value":"PRODUCT-14325616"},{"@type":"KAKEN","@value":"PRODUCT-13166992"},{"@type":"KAKEN","@value":"PRODUCT-13200180"},{"@type":"KAKEN","@value":"PRODUCT-14325580"},{"@type":"OPENAIRE","@value":"doi_dedup___::260d956f8990c830f1771161f47deefe"}]}