{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848655243281152.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/term.2647"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fterm.2647"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full/10.1002/term.2647"}},{"identifier":{"@type":"PMID","@value":"29377539"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Therapeutic effects of a recombinant human collagen peptide bioscaffold with human adipose-derived stem cells on impaired wound healing after radiotherapy"}],"description":[{"notation":[{"@value":"Chronic changes following radiotherapy include alterations in tissue-resident stem cells and vasculatures, which can lead to impaired wound healing. In this study, novel recombinant human collagen peptide (rhCP) scaffolds were evaluated as a biomaterial carrier for cellular regenerative therapy. Human adipose-derived stem cells (hASCs) were successfully cultured on rhCP scaffolds. By hASC culture on rhCP, microarray assay indicated that expression of genes related to cell proliferation and extracellular matrix production was upregulated. Pathway analyses revealed that signaling pathways related to inflammatory suppression and cell growth promotion were activated as well as signaling pathways consistent with some growth factors including vascular endothelial growth factor, hepatocyte growth factor, and transforming growth factor beta, although gene expression of these growth factors was not upregulated. These findings suggest the rhCP scaffold showed similar biological actions to cytokines regulating cell growth and immunity. In subsequent impaired wound healing experiments using a locally irradiated (20 Gray) mouse, wound treatment with rhCP sponges combined with cultured hASCs and human umbilical vein endothelial cells accelerated wound closure compared with wounds treated with rhCP with hASCs alone, rhCP only, and control (dressing alone), with better healing observed according to this order. These results indicating the therapeutic value of rhCP scaffolds as a topical biomaterial dressing and a biocarrier of stem cells and vascular endothelial cells for regenerating therapies. The combination of rhCP and functional cells was suggested to be a potential tool for revitalizing stem cell-depleted conditions such as radiation tissue damage."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848655243281154","@type":"Researcher","foaf:name":[{"@value":"Takanobu Mashiko"}],"jpcoar:affiliationName":[{"@value":"Department of Plastic Surgery; Jichi Medical University; Tochigi Japan"},{"@value":"Department of Plastic Surgery; University of Tokyo, School of Medicine; Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655243280897","@type":"Researcher","foaf:name":[{"@value":"Hitomi Takada"}],"jpcoar:affiliationName":[{"@value":"Stem Cell Technologies lab, Graduate School of Biological Sciences; Nara Institute of Science and Technology; Nara Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655243281025","@type":"Researcher","foaf:name":[{"@value":"Szu-Hsien Wu"}],"jpcoar:affiliationName":[{"@value":"Department of Plastic Surgery; University of Tokyo, School of Medicine; Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801208641920","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40612601"},{"@type":"NRID","@value":"1000040612601"},{"@type":"NRID","@value":"9000409882963"},{"@type":"NRID","@value":"9000398384563"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kk040404061205"}],"foaf:name":[{"@value":"Koji Kanayama"}],"jpcoar:affiliationName":[{"@value":"Department of Plastic Surgery; Jichi Medical University; Tochigi Japan"},{"@value":"Department of Plastic Surgery; University of Tokyo, School of Medicine; Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655243281159","@type":"Researcher","foaf:name":[{"@value":"Jingwei Feng"}],"jpcoar:affiliationName":[{"@value":"Department of Plastic Surgery; University of Tokyo, School of Medicine; Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655243280899","@type":"Researcher","foaf:name":[{"@value":"Kensuke Tashiro"}],"jpcoar:affiliationName":[{"@value":"Department of Plastic Surgery; University of Tokyo, School of Medicine; Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655243281156","@type":"Researcher","foaf:name":[{"@value":"Rintaro Asahi"}],"jpcoar:affiliationName":[{"@value":"Department of Plastic Surgery; Jichi Medical University; Tochigi Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655243281153","@type":"Researcher","foaf:name":[{"@value":"Ataru Sunaga"}],"jpcoar:affiliationName":[{"@value":"Department of Plastic Surgery; Jichi Medical University; Tochigi Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655243281286","@type":"Researcher","foaf:name":[{"@value":"Kazuto Hoshi"}],"jpcoar:affiliationName":[{"@value":"Department of Oral Surgery; University of Tokyo, School of Medicine; Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655243281285","@type":"Researcher","foaf:name":[{"@value":"Akira Kurisaki"}],"jpcoar:affiliationName":[{"@value":"Stem Cell Technologies lab, Graduate School of Biological Sciences; Nara Institute of Science and Technology; Nara Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326214584704","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90171454"},{"@type":"NRID","@value":"1000090171454"},{"@type":"CINII_AUTHOR_ID","@value":"DA11566954"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA11566954#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA11566954"},{"@type":"NRID","@value":"9000260368793"},{"@type":"NRID","@value":"9000259334524"},{"@type":"NRID","@value":"9000015314294"},{"@type":"NRID","@value":"9000356657903"},{"@type":"NRID","@value":"9000308727422"},{"@type":"NRID","@value":"9000396152652"},{"@type":"NRID","@value":"9000316694307"},{"@type":"NRID","@value":"9000323840554"},{"@type":"NRID","@value":"9000397866366"},{"@type":"NRID","@value":"9000258382873"},{"@type":"NRID","@value":"9000343340587"},{"@type":"NRID","@value":"9000315146232"},{"@type":"NRID","@value":"9000383708182"},{"@type":"NRID","@value":"9000396111072"},{"@type":"NRID","@value":"9000397963661"},{"@type":"NRID","@value":"9000376944958"},{"@type":"NRID","@value":"9000308727395"},{"@type":"NRID","@value":"9000305639890"},{"@type":"NRID","@value":"9000020266865"},{"@type":"NRID","@value":"9000283676198"},{"@type":"NRID","@value":"9000379555115"},{"@type":"NRID","@value":"9000258382771"},{"@type":"NRID","@value":"9000242255774"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0157029"}],"foaf:name":[{"@value":"Tsuyoshi Takato"}],"jpcoar:affiliationName":[{"@value":"Department of Oral Surgery; University of Tokyo, School of Medicine; Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655243281029","@type":"Researcher","foaf:name":[{"@value":"Kotaro Yoshimura"}],"jpcoar:affiliationName":[{"@value":"Department of Plastic Surgery; Jichi Medical University; Tochigi Japan"},{"@value":"Department of Plastic Surgery; University of Tokyo, School of Medicine; Tokyo Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"19326254"}],"prism:publicationName":[{"@value":"Journal of Tissue Engineering and Regenerative Medicine"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2018-03-04","prism:volume":"12","prism:number":"5","prism:startingPage":"1186","prism:endingPage":"1194"},"reviewed":"false","dc:rights":["http://doi.wiley.com/10.1002/tdm_license_1.1","http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fterm.2647"},{"@id":"https://onlinelibrary.wiley.com/doi/full/10.1002/term.2647"}],"createdAt":"2018-01-26","modifiedAt":"2022-12-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20BALB%20C","dc:title":"Mice, Inbred BALB C"},{"@id":"https://cir.nii.ac.jp/all?q=Wound%20Healing","dc:title":"Wound Healing"},{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20Scaffolds","dc:title":"Tissue Scaffolds"},{"@id":"https://cir.nii.ac.jp/all?q=Stem%20Cells","dc:title":"Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Nude","dc:title":"Mice, Nude"},{"@id":"https://cir.nii.ac.jp/all?q=Recombinant%20Proteins","dc:title":"Recombinant Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Adipose%20Tissue","dc:title":"Adipose Tissue"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Collagen","dc:title":"Collagen"},{"@id":"https://cir.nii.ac.jp/all?q=Peptides","dc:title":"Peptides"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781904319744","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16J01745"},{"@type":"JGN","@value":"JP16J01745"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16J01745/"}],"notation":[{"@language":"ja","@value":"幹細胞枯渇病態に対する組織再生治療法の開発"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256950333568","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K17040"},{"@type":"JGN","@value":"JP17K17040"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K17040/"}],"notation":[{"@language":"ja","@value":"リンパ浮腫脂肪組織における免疫細胞解析による病態解明と免疫機能再建外科治療の確立"},{"@language":"en","@value":"Immunologic assessment in lymphedema adipose tissue and establishment of immuno-reconstruction"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256952143104","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K19744"},{"@type":"JGN","@value":"JP17K19744"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19744/"}],"notation":[{"@language":"ja","@value":"ゲノムワイドアプローチによる骨再生用細胞遊走因子の同定と応用に関する探索的研究"},{"@language":"en","@value":"Identification of regulatory factors contributing to migration or recruitment of osteoblast progenitors by genome-wide approach and the application for bone repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256981728512","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K16979"},{"@type":"JGN","@value":"JP18K16979"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16979/"}],"notation":[{"@language":"ja","@value":"毛包由来間葉系細胞の混合移植による毛髪再生"},{"@language":"en","@value":"Hair regeneration by dermal papilla and sheath cells construct"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001201940763904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Adipose tissue formation in collagen scaffolds with different biodegradabilities."}]},{"@id":"https://cir.nii.ac.jp/crid/1050287297263524480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142853337088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Selective Proliferation of Highly Functional Adipose-Derived Stem Cells in Microgravity Culture with Stirred Microspheres"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025431139508096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Analysis of the Effect of Human Type I Collagen-Derived Peptide on Bone Regenerative Capacity and Comparison with Various Collagen Materials In Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617417054976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bone forming ability of recombinant human collagen peptide granules applied with β‐tricalcium phosphate fine particles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620049747712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of radiation-induced skin injury and implications for future clinical trials"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093634916608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Updates on stem cells and their applications in regenerative medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096020387200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fat Grafting to the Breast and Adipose-Derived Stem Cells: Recent Scientific Consensus and Controversy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659838021504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanical Micronization of Lipoaspirates: Squeeze and Emulsification Techniques"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570168862976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"How Does Fat Survive and Remodel After Grafting?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570280796800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Osteogenesis and mineralization of mesenchymal stem cells in collagen type I‐based recombinant peptide scaffolds"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571368954624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biomimetic mineralization of recombinant collagen type I derived protein to obtain hybrid matrices for bone regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045611299456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046131958400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518654679424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cell-Assisted Lipotransfer Improves Volume Retention in Irradiated Recipient Sites and Rescues Radiation-Induced Skin Changes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518696180992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adipose-Derived Stem Cells Improve Survival of Random Pattern Cutaneous Flaps in Radiation Damaged Skin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518772919296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520235656832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994202567424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adipose-derived stem cells (ASCs) as a source of endothelial cells in the reconstruction of endothelialized skin equivalents"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995501422848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endogenous Stem Cell Therapy Enhances Fat Graft Survival"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469653140992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stem Cell Therapy to Reduce Radiation-Induced Normal Tissue Damage"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470433529600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The potential of mesenchymal stem cells in the management of radiation enteropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944238922624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Response of normal stem cells to ionizing radiation: A balance between homeostasis and genomic stability"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945343603456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recombinant Gelatin Microspheres: Novel Formulations for Tissue Repair?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945505574912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of recombinant collagen‐peptide‐based vehicles for delivery of adipose‐derived stromal cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945752578688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protective efficacy of intravenous transplantation of adipose-derived stem cells for the prevention of radiation-induced salivary gland damage"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419523417472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420680890624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Skin Injuries from Fluoroscopically Guided Procedures"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421133904384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Integrin regulation of growth factor receptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421136456576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical Treatment of Radiotherapy Tissue Damage by Lipoaspirate Transplant: A Healing Process Mediated by Adipose-Derived Adult Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421204362368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Radiation Combined Injury Models to Study the Effects of Interventions and Wound Biomechanics"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371226226176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843952062464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modulation of Immune Response and T-Cell Regulation by Donor Adipose-Derived Stem Cells in a Rodent Hind-Limb Allotransplant Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845175224064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Wound healing after radiation therapy: Review of the literature"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846198679808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cross-Linking in Biomaterials"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318521405440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A new fluorescent imaging of renal inflammation with RCP"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320160277248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795863113344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Robust Functional Vascular Network Formation In Vivo by Cooperation of Adipose Progenitor and Endothelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270827812992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"New bioactive bone-like microspheres with intrinsic magnetic properties obtained by bio-inspired mineralisation process"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270915252352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hyaluronic acid-recombinant gelatin gels as a scaffold for soft tissue regeneration"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/term.2647"},{"@type":"KAKEN","@value":"PRODUCT-22383173"},{"@type":"KAKEN","@value":"PRODUCT-23151974"},{"@type":"KAKEN","@value":"PRODUCT-22132549"},{"@type":"KAKEN","@value":"PRODUCT-22500985"},{"@type":"OPENAIRE","@value":"doi_dedup___::702a48796c240a375f4efbfadf2893f1"},{"@type":"CROSSREF","@value":"10.3390/cells10030560_references_DOI_WsVjnuCflS9kU3PjvGnw3XvDcdr"},{"@type":"CROSSREF","@value":"10.3390/medicina61010057_references_DOI_WsVjnuCflS9kU3PjvGnw3XvDcdr"},{"@type":"CROSSREF","@value":"10.1002/jbm.b.34632_references_DOI_WsVjnuCflS9kU3PjvGnw3XvDcdr"}]}