{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848655422624384.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/978-1-62703-724-2_12"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1007/978-1-62703-724-2_12"}},{"identifier":{"@type":"PMID","@value":"24218257"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Purification, Measurement of Concentration, and Functional Complement Assay of Human Ficolins"}],"description":[{"notation":[{"@value":"Ficolins constitute a group of lectins involved in innate immunity. L-Ficolin, H-ficolin, and M-ficolin are present in human serum. The human ficolins differ in carbohydrate-binding specificity, but they have in common the ability to recognize the acetyl group. L-Ficolin and H-ficolin are associated with serine proteases termed MASPs (MBL-associated serine proteases) and their truncated proteins, and the complexes (L/H-ficolin-MASP) activate the lectin pathway of complement upon binding to their ligands. Recombinant M-ficolin is also able to form a complex with MASP, resulting in complement activation. L-Ficolin and H-ficolin can be purified as a complex with MASP from serum by utilizing their binding specificities. These ficolin-MASP complexes have an ability to activate C4. Human ficolins are quantified by ELISA using specific antibodies or ligands."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848655422624132","@type":"Researcher","foaf:name":[{"@value":"Misao Matsushita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655422624260","@type":"Researcher","foaf:name":[{"@value":"David Kilpatrick"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655422624384","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Shiraki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655422624133","@type":"Researcher","foaf:name":[{"@value":"Yu Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655422624134","@type":"Researcher","foaf:name":[{"@value":"Koichiro Tateishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655422624257","@type":"Researcher","foaf:name":[{"@value":"Mitsushi Tsujimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326229013760","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20117427"},{"@type":"NRID","@value":"1000020117427"},{"@type":"NRID","@value":"9000283407735"},{"@type":"NRID","@value":"9000258727894"}],"foaf:name":[{"@value":"Yuichi Endo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848655422624128","@type":"Researcher","foaf:name":[{"@value":"Teizo Fujita"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10643745"},{"@type":"EISSN","@value":"19406029"},{"@type":"ISBN","@value":"9781627037235"},{"@type":"ISBN","@value":"9781627037242"}],"prism:publicationName":[{"@value":"Methods in Molecular Biology"}],"dc:publisher":[{"@value":"Humana Press"}],"prism:publicationDate":"2013-10-22","prism:volume":"1100","prism:startingPage":"141","prism:endingPage":"159"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.springernature.com/gp/researchers/text-and-data-mining","https://www.springernature.com/gp/researchers/text-and-data-mining"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1007/978-1-62703-724-2_12"}],"createdAt":"2013-11-11","modifiedAt":"2023-02-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Lectins","dc:title":"Lectins"},{"@id":"https://cir.nii.ac.jp/all?q=Mannose-Binding%20Protein-Associated%20Serine%20Proteases","dc:title":"Mannose-Binding Protein-Associated Serine Proteases"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme-Linked%20Immunosorbent%20Assay","dc:title":"Enzyme-Linked Immunosorbent Assay"},{"@id":"https://cir.nii.ac.jp/all?q=Complement%20System%20Proteins","dc:title":"Complement System Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Ficolins","dc:title":"Ficolins"},{"@id":"https://cir.nii.ac.jp/all?q=Complement%20Activation","dc:title":"Complement Activation"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257235213312","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25460596"},{"@type":"JGN","@value":"JP25460596"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460596/"}],"notation":[{"@language":"ja","@value":"認識分子フィコリンの恒常性維持に果たす新たな役割と分子基盤の解明"},{"@language":"en","@value":"Molecular basis of a new role of ficolin on endogenous homeostasis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144550584576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Novel Mannose-binding Lectin/Ficolin-associated Protein Is Highly Expressed in Heart and Skeletal Muscle Tissues and 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