{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848656452065408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s12192-018-0922-1"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s12192-018-0922-1/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s12192-018-0922-1.pdf"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1355814523008088?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1355814523008088?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"29876727"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Ions released from a S-PRG filler induces oxidative stress in Candida albicans inhibiting its growth and pathogenicity"}],"description":[{"notation":[{"@value":"Candida albicans causes opportunistic fungal infections usually hidden among more dominant bacteria and does not exhibit high pathogenicity in vivo. Among the elderly, due to reduced host resistance to pathogens attributable to immunoscenesence, oral candidiasis is more likely to develop often leading to systemic candidiasis. Surface pre-reacted glass ionomer filler (S-PRG filler) is an ion-releasing functional bioactive glass that can release and recharge six ions which in turn strengthens tooth structure, inhibits demineralization arising from dental caries, and suppresses dental plaque accumulation. However, its effects on C. albicans have never been elucidated. Here, we evaluated the effects of ion released from S-PRG filler on C. albicans. Results show that extraction liquids containing released ions (ELIS) decreased the amount of hydrogen peroxide and catalase activity in C. albicans. Moreover, ELIS presence was found to affect C. albicans: (1) suppression of fungal growth and biofilm formation, (2) prevent adherence to denture base resin, (3) inhibit dimorphism conversion, and (4) hinder the capability to produce secreted aspartyl proteinase. Taken together, our findings suggest that ELIS induces oxidative stress in C. albicans and suppresses its growth and pathogenicity. In this regard, we propose that ELIS has the potential to be clinically used to help prevent the onset and inhibition of oral candidiasis among the elderly population."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326208043648","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30227293"},{"@type":"NRID","@value":"1000030227293"},{"@type":"ORCID","@value":"0000-0002-8637-1579"},{"@type":"NRID","@value":"9000004728796"},{"@type":"NRID","@value":"9000243886844"},{"@type":"NRID","@value":"9000257907473"},{"@type":"NRID","@value":"9000254649121"},{"@type":"NRID","@value":"9000370735322"},{"@type":"NRID","@value":"9000256359260"},{"@type":"NRID","@value":"9000019239805"},{"@type":"NRID","@value":"9000405634058"},{"@type":"NRID","@value":"9000022207742"},{"@type":"NRID","@value":"9000399599542"},{"@type":"NRID","@value":"9000254194744"},{"@type":"NRID","@value":"9000414517729"},{"@type":"NRID","@value":"9000397957690"},{"@type":"NRID","@value":"9000257942833"},{"@type":"NRID","@value":"9000256359130"},{"@type":"NRID","@value":"9000369741780"},{"@type":"NRID","@value":"9000254194732"},{"@type":"NRID","@value":"9000256358887"},{"@type":"NRID","@value":"9000366513556"},{"@type":"NRID","@value":"9000258315743"},{"@type":"NRID","@value":"9000258316687"},{"@type":"NRID","@value":"9000018770956"},{"@type":"NRID","@value":"9000405634301"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0028722"}],"foaf:name":[{"@value":"Muneaki Tamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656452065544","@type":"Researcher","foaf:name":[{"@value":"Marni E. Cueno"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656452065539","@type":"Researcher","foaf:name":[{"@value":"Kazumasa Abe"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276187506304","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60546472"},{"@type":"NRID","@value":"1000060546472"},{"@type":"NRID","@value":"9000414942326"},{"@type":"NRID","@value":"9000399599541"},{"@type":"NRID","@value":"9000356631282"},{"@type":"NRID","@value":"9000001828249"},{"@type":"NRID","@value":"9000275835332"},{"@type":"NRID","@value":"9000411082594"},{"@type":"NRID","@value":"9000404003713"},{"@type":"NRID","@value":"9000378112728"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000000043"}],"foaf:name":[{"@value":"Noriaki Kamio"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656452065416","@type":"Researcher","foaf:name":[{"@value":"Kuniyasu Ochiai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656452065417","@type":"Researcher","foaf:name":[{"@value":"Kenichi Imai"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13558145"}],"prism:publicationName":[{"@value":"Cell Stress and Chaperones"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2018-11","prism:volume":"23","prism:number":"6","prism:startingPage":"1337","prism:endingPage":"1343"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"http://link.springer.com/article/10.1007/s12192-018-0922-1/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s12192-018-0922-1.pdf"},{"@id":"https://api.elsevier.com/content/article/PII:S1355814523008088?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1355814523008088?httpAccept=text/plain"}],"createdAt":"2018-06-06","modifiedAt":"2025-10-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Ions","dc:title":"Ions"},{"@id":"https://cir.nii.ac.jp/all?q=Denture%20Bases","dc:title":"Denture Bases"},{"@id":"https://cir.nii.ac.jp/all?q=Aspartic%20Acid%20Proteases","dc:title":"Aspartic Acid Proteases"},{"@id":"https://cir.nii.ac.jp/all?q=Acrylic%20Resins","dc:title":"Acrylic Resins"},{"@id":"https://cir.nii.ac.jp/all?q=Catalase","dc:title":"Catalase"},{"@id":"https://cir.nii.ac.jp/all?q=Silicon%20Dioxide","dc:title":"Silicon Dioxide"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Candidiasis,%20Oral","dc:title":"Candidiasis, Oral"},{"@id":"https://cir.nii.ac.jp/all?q=Glass%20Ionomer%20Cements","dc:title":"Glass Ionomer Cements"},{"@id":"https://cir.nii.ac.jp/all?q=Biofilms","dc:title":"Biofilms"},{"@id":"https://cir.nii.ac.jp/all?q=Candida%20albicans","dc:title":"Candida albicans"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Adhesion","dc:title":"Cell Adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782001582848","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K09892"},{"@type":"JGN","@value":"JP18K09892"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K09892/"}],"notation":[{"@language":"ja","@value":"高齢者の歯周病および関連する全身疾患の予防に有効な新規口腔ケア剤の開発"},{"@language":"en","@value":"Development of a new effective oral care agent for the prevention of periodontal disease-related systemic diseases among the elderly"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256978312576","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K09920"},{"@type":"JGN","@value":"JP18K09920"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K09920/"}],"notation":[{"@language":"ja","@value":"口腔細菌の制御を基盤としたインフルエンザ予防戦略の確立に向けた基礎的研究"},{"@language":"en","@value":"Exploring the influence of oral bacteria on influenza virus infection"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009581769619072","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of direct restorative dental materials on surface root caries treatment. Evidence based and current materials development: A systematic review"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144892150912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deletion of the high‐affinity cAMP phosphodiesterase encoded by <i>PDE2</i> affects stress responses and virulence in <i>Candida albicans</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145527384320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oral Colonization By Candida Albicans"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146184189184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of hyphal growth of a vesicular-arbuscular mycorrhizal fungus in soil containing sodium chloride limits the spread of infection from spores"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168881972224","@type":"Article","resourceType":"学術雑誌論文(journal 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filler"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045689154176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biofilm Formation by the Fungal Pathogen\n            <i>Candida albicans</i>\n            : Development, Architecture, and Drug Resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518413265536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Association Between Oral Microorgansims and Aspiration Pneumonia in the Institutionalized Elderly: Review and Recommendations"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519092896896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of fluoride on bacterial growth and its gene/protein expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469178653952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>In-vitro</i>inhibition of mycelial growth of several phytopathogenic fungi by soluble potassium silicate"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470775118592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential secretion of Sap4–6 proteins in Candida albicans during hyphae formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944142839808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hydrogen peroxide: a Jekyll and Hyde signalling molecule"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944602222976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Varying hemin concentrations affect Porphyromonas gingivalis strains differently"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419258698240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Two-year clinical evaluation of flowable composite resin containing pre-reacted 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