{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848656925751040.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbamcr.2013.01.001"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0167488913000062?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0167488913000062?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"23328083"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB"}],"description":[{"notation":[{"@value":"Sphingosine kinase 1 (SPHK1) overexpression in malignant cells has been reported. Mouse Friend cells showed higher SPHK1 but not SPHK2 expression compared with other mouse cell lines. A Sphk1 promoter analysis demonstrated the region between -53bp and the first exon as the minimal promoter. Further promoter truncation revealed the importance of a MYB-binding site. EMSA using this region as the probe demonstrated one band containing c-MYB protein, and its intensity decreased during erythroid differentiation with hexamethylane bisacetamide (HMBA), a potent inducer of erythroid differentiation of Friend cells. ChIP assay also revealed in vivo binding of c-MYB. c-MYB overexpression and siRNA for c-Myb affected SPHK1 expression, confirming the important regulatory role of c-MYB in SPHK1 expression. HMBA reduced c-MYB expression rapidly. Induced differentiation by HMBA caused a marked and rapid reduction of SPHK1 mRNA, protein and enzyme activity leading to the rapid decrease of cellular sphingosine 1-phosphate level. Moreover, terminally differentiated cells did not resume SPHK1 expression. Compared with original Friend cells, stable overexpression of wild-type SPHK1 showed higher cell proliferation, resistance to cell death by serum depletion. Interestingly, HMBA-induced differentiation of these cells was delayed but not completely suppressed. In contrast, SPHK inhibitor and its siRNA inhibited cell growth and enhanced HMBA-induced differentiation significantly, suggesting that SPHK1 delayed HMBA-induced differentiation by its cell proliferation-promoting activity. Effects of pertussis toxin, a G-protein-coupled receptor inhibitor, and S1P receptor antagonist on Friend cell growth and differentiation were negligible, suggesting the importance of the intracellular SPHK1/S1P signaling in Friend cells."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848656925751048","@type":"Researcher","foaf:name":[{"@value":"N. Mizutani"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751170","@type":"Researcher","foaf:name":[{"@value":"M. Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751045","@type":"Researcher","foaf:name":[{"@value":"S. Sobue"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751052","@type":"Researcher","foaf:name":[{"@value":"M. Ichihara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751051","@type":"Researcher","foaf:name":[{"@value":"H. Ito"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751054","@type":"Researcher","foaf:name":[{"@value":"K. Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751043","@type":"Researcher","foaf:name":[{"@value":"S. Iwaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751168","@type":"Researcher","foaf:name":[{"@value":"S. Fujii"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751050","@type":"Researcher","foaf:name":[{"@value":"Y. Ito"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751047","@type":"Researcher","foaf:name":[{"@value":"K. Tamiya-Koizumi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751044","@type":"Researcher","foaf:name":[{"@value":"A. Takagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751041","@type":"Researcher","foaf:name":[{"@value":"T. Kojima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751046","@type":"Researcher","foaf:name":[{"@value":"T. Naoe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751169","@type":"Researcher","foaf:name":[{"@value":"M. Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751042","@type":"Researcher","foaf:name":[{"@value":"M. Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751040","@type":"Researcher","foaf:name":[{"@value":"Y. Banno"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751049","@type":"Researcher","foaf:name":[{"@value":"Y. Nozawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848656925751053","@type":"Researcher","foaf:name":[{"@value":"T. Murate"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01674889"}],"prism:publicationName":[{"@value":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2013-05","prism:volume":"1833","prism:number":"5","prism:startingPage":"1006","prism:endingPage":"1016"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0167488913000062?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0167488913000062?httpAccept=text/plain"}],"createdAt":"2013-01-14","modifiedAt":"2022-02-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Biology","dc:title":"Cell Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular 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