{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848657106947712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.heares.2016.06.012"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0378595516301137?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0378595516301137?httpAccept=text/xml"}},{"identifier":{"@type":"PMID","@value":"27321205"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Neural response differences in the rat primary auditory cortex under anesthesia with ketamine versus the mixture of medetomidine, midazolam and butorphanol"}],"description":[{"notation":[{"@value":"Anesthesia affects central auditory processing. However, it is unclear to what extent the choice of anesthetic agent affects neural responses to sound stimulation. A mixture of three anesthetics (medetomidine, midazolam and butorphanol; MMB) was recently developed as an alternative to ketamine owing to the latter's addictive potential, yet the effect of this combination of anesthetics on neural responses is not known. Here, we compared the spontaneous activity, tuning properties and temporal responses of primary auditory cortical neurons under these two anesthetic conditions, using electrophysiological and flavoprotein autofluorescence imaging methods. Frequency tuning properties were not significantly different between ketamine and MMB anesthesia. However, neural activity under MMB showed decreases in the spontaneous and tone-evoked firing rates in a layer-dependent manner. Moreover, the temporal response patterns were also different between the anesthetics in a layer-dependent manner, which may reflect differences in the anesthetic mechanisms. These results demonstrated how response properties in the primary auditory cortex are affected by the choice of anesthesia."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848657106947712","@type":"Researcher","foaf:name":[{"@value":"Hisayuki Osanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751146029056","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00314401"},{"@type":"NRID","@value":"1000000314401"},{"@type":"NRID","@value":"9000002736500"},{"@type":"NRID","@value":"9000004952109"},{"@type":"NRID","@value":"9000321619452"},{"@type":"NRID","@value":"9000303638346"},{"@type":"NRID","@value":"9000321619497"},{"@type":"NRID","@value":"9000388503957"},{"@type":"NRID","@value":"9000241960458"},{"@type":"NRID","@value":"9000004948729"},{"@type":"NRID","@value":"9000314076778"},{"@type":"NRID","@value":"9000356610492"},{"@type":"NRID","@value":"9000377372440"},{"@type":"NRID","@value":"9000018527585"},{"@type":"NRID","@value":"9000020171937"},{"@type":"NRID","@value":"9000397849463"},{"@type":"NRID","@value":"9000388997189"},{"@type":"NRID","@value":"9000398285661"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tat"}],"foaf:name":[{"@value":"Takashi Tateno"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03785955"}],"prism:publicationName":[{"@value":"Hearing Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2016-09","prism:volume":"339","prism:startingPage":"69","prism:endingPage":"79"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0378595516301137?httpAccept=text/plain"},{"@id":"https://api.elsevier.com/content/article/PII:S0378595516301137?httpAccept=text/xml"}],"createdAt":"2016-06-21","modifiedAt":"2022-07-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Auditory%20Cortex","dc:title":"Auditory Cortex"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Xylazine","dc:title":"Xylazine"},{"@id":"https://cir.nii.ac.jp/all?q=Anesthetics,%20Dissociative","dc:title":"Anesthetics, Dissociative"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Flavoproteins","dc:title":"Flavoproteins"},{"@id":"https://cir.nii.ac.jp/all?q=Midazolam","dc:title":"Midazolam"},{"@id":"https://cir.nii.ac.jp/all?q=Medetomidine","dc:title":"Medetomidine"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Electrophysiology","dc:title":"Electrophysiology"},{"@id":"https://cir.nii.ac.jp/all?q=Butorphanol","dc:title":"Butorphanol"},{"@id":"https://cir.nii.ac.jp/all?q=Hearing","dc:title":"Hearing"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Anesthesia","dc:title":"Anesthesia"},{"@id":"https://cir.nii.ac.jp/all?q=Ketamine","dc:title":"Ketamine"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Anesthetics","dc:title":"Anesthetics"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781826527488","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H02772"},{"@type":"JGN","@value":"JP15H02772"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02772/"}],"notation":[{"@language":"ja","@value":"耳鳴り抑制：閉ループ型実時間情報処理を備えた微小電気刺激装置開発と覚醒脳への展開"},{"@language":"en","@value":"Suppression of tinnitus: developing a micro-electric stimulator with closed-loop real-time information processing and its application to awake brains"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256832142208","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K12091"},{"@type":"JGN","@value":"JP15K12091"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K12091/"}],"notation":[{"@language":"ja","@value":"内耳蝸牛内電位駆動型の非常用電力体内給電システムの基盤技術開発とその評価"},{"@language":"en","@value":"Development and evaluation of the basic technology for an energy extraction system from biological buttery including electrical potentials generated in the inner ear"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218156075264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anesthetic effects of isoflurane on the tonotopic map and neuronal population activity in the rat auditory cortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232398697856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An analysis of nonlinear dynamics underlying neural activity related to auditory induction in the rat auditory cortex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144462680704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-term, partially-reversible reorganization of frequency tuning in mature cat primary 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