{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848657135329408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.ijpharm.2015.03.073"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0378517315002896?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0378517315002896?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"25841568"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane"}],"description":[{"notation":[{"@value":"Nano-/microbubbles are expected not only to function as ultrasound contrast agents but also as ultrasound-triggered enhancers in gene and drug delivery. Notably, nanobubbles have the ability to pass through tumor vasculature and achieve passive tumor targeting. Thus, nanobubbles would be an attractive tool for use as ultrasound-mediated cancer theranostics. However, the amounts of gas carried by nanobubbles are generally lower than those carried by microbubbles because nanobubbles have inherently smaller volumes. In order to reduce the injection volume and to increase echogenicity, it is important to develop nanobubbles with higher gas content. In this study, we prepared 5 kinds of fluoro-lipids and used these reagents as surfactants to generate \"Bubble liposomes\", that is, liposomes that encapsulate nanobubbles such that the lipids serve as stabilizers between the fluorous gas and water phases. Bubble liposome containing 1-stearoyl-2-(18,18-difluoro)stearoyl-sn-glycero-3-phosphocholine carried 2-fold higher amounts of C3F8 compared to unmodified Bubble liposome. The modified Bubble liposome also exhibited increased echogenicity by ultrasonography. These results demonstrated that the inclusion of fluoro-lipid is a promising tool for generating nanobubbles with increased efficiency of fluorous gas carrier."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326236249344","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80505941"},{"@type":"NRID","@value":"1000080505941"},{"@type":"NRID","@value":"9000261677927"},{"@type":"NRID","@value":"9000006640577"},{"@type":"NRID","@value":"9000345404604"}],"foaf:name":[{"@value":"Yusuke Oda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657135329415","@type":"Researcher","foaf:name":[{"@value":"Ryo Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657135329416","@type":"Researcher","foaf:name":[{"@value":"Tatsuya Mori"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657135329418","@type":"Researcher","foaf:name":[{"@value":"Hideyo Takahashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657135329410","@type":"Researcher","foaf:name":[{"@value":"Hideaki 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Hashida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657135329420","@type":"Researcher","foaf:name":[{"@value":"Kazuo Maruyama"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03785173"}],"prism:publicationName":[{"@value":"International Journal of Pharmaceutics"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2015-06","prism:volume":"487","prism:number":"1-2","prism:startingPage":"64","prism:endingPage":"71"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0378517315002896?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0378517315002896?httpAccept=text/plain"}],"createdAt":"2015-04-05","modifiedAt":"2018-09-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Carriers","dc:title":"Drug Carriers"},{"@id":"https://cir.nii.ac.jp/all?q=Fluorocarbons","dc:title":"Fluorocarbons"},{"@id":"https://cir.nii.ac.jp/all?q=Microbubbles","dc:title":"Microbubbles"},{"@id":"https://cir.nii.ac.jp/all?q=Contrast%20Media","dc:title":"Contrast Media"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Delivery%20Systems","dc:title":"Drug Delivery Systems"},{"@id":"https://cir.nii.ac.jp/all?q=Liposomes","dc:title":"Liposomes"},{"@id":"https://cir.nii.ac.jp/all?q=Gases","dc:title":"Gases"},{"@id":"https://cir.nii.ac.jp/all?q=Particle%20Size","dc:title":"Particle Size"},{"@id":"https://cir.nii.ac.jp/all?q=Phospholipids","dc:title":"Phospholipids"},{"@id":"https://cir.nii.ac.jp/all?q=Ultrasonography","dc:title":"Ultrasonography"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782273591168","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25860397"},{"@type":"JGN","@value":"JP25860397"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860397/"}],"notation":[{"@language":"ja","@value":"診断と治療を包括的に実行するための新規ナノ・マイクロバブルの開発"},{"@language":"en","@value":"Development of nano/microbubbles for ultrasound mediated theranostics"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050005822298974848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Application of Direct Sonoporation from a Defined Surface Area of the Peritoneum: Evaluation of Transfection Characteristics in 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