{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848657206066688.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.jff.2018.04.017"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1756464618301579?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1756464618301579?httpAccept=text/plain"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"DHA enriched phospholipids with different polar groups (PC and PS) had different improvements on MPTP-induced mice with Parkinson’s disease"}],"description":[{"notation":[{"@value":"Docosahexaenoic acid (DHA) enriched phospholipids such as phosphatidylcholine (PC) and phosphatidylserine (PS) are important bioactive components and widely distributed in multifarious marine products. In the present study, we investigated the effects of DHA enriched phospholipids with different polar groups (DHA-PC and DHA-PS) on MPTP-induced PD mice by behavioral experiments including rotarod test and open field test as well as immunohistochemistry. Three DHA supplements all exhibited observable protective effects on PD symptoms of MPTP-induced mice and increased the number of dopaminergic neurons, especially DHA-PS had better improvement than DHA-TG and DHA-PC. Further analysis indicated that DHA additive pretreatment could inhibit apoptosis via mitochondria - mediated pathway and MAPK pathway, and thus protecting dopaminergic neurons in MPTP-induced mice. These results suggested that DHA enriched phospholipids with different polar groups exerted varying improvements on MPTP-induced PD mice, which represented a potential novel therapeutic candidate for the prevention and treatment of neurodegenerative diseases."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848657206066690","@type":"Researcher","foaf:name":[{"@value":"Chengcheng Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657206066688","@type":"Researcher","foaf:name":[{"@value":"Jie Xu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657206066691","@type":"Researcher","foaf:name":[{"@value":"Dan Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801181357952","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00093980"},{"@type":"NRID","@value":"1000000093980"},{"@type":"NRID","@value":"9000022201591"},{"@type":"NRID","@value":"9000021006819"},{"@type":"NRID","@value":"9000018237482"},{"@type":"NRID","@value":"9000021127235"},{"@type":"NRID","@value":"9000021022178"},{"@type":"NRID","@value":"9000257771692"},{"@type":"NRID","@value":"9000380125637"},{"@type":"NRID","@value":"9000398259026"},{"@type":"NRID","@value":"9000020718356"},{"@type":"NRID","@value":"9000020906006"},{"@type":"NRID","@value":"9000408918811"},{"@type":"NRID","@value":"9000399604695"},{"@type":"NRID","@value":"9000237691927"},{"@type":"NRID","@value":"9000020210196"},{"@type":"NRID","@value":"9000020877894"},{"@type":"NRID","@value":"9000001864695"},{"@type":"NRID","@value":"9000345335694"},{"@type":"NRID","@value":"9000006433014"},{"@type":"NRID","@value":"9000004187386"},{"@type":"NRID","@value":"9000021038761"},{"@type":"NRID","@value":"9000020082947"},{"@type":"NRID","@value":"9000022196909"},{"@type":"NRID","@value":"9000020066575"},{"@type":"NRID","@value":"9000020816148"},{"@type":"NRID","@value":"9000398833726"},{"@type":"NRID","@value":"9000398798485"},{"@type":"NRID","@value":"9000253229571"},{"@type":"NRID","@value":"9000401955499"},{"@type":"NRID","@value":"9000020676491"},{"@type":"NRID","@value":"9000018483502"},{"@type":"NRID","@value":"9000326649972"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0172539"}],"foaf:name":[{"@value":"Teruyoshi Yanagita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657206066693","@type":"Researcher","foaf:name":[{"@value":"Tiantian Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657206066694","@type":"Researcher","foaf:name":[{"@value":"Yuming Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657206066689","@type":"Researcher","foaf:name":[{"@value":"Changhu Xue"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"17564646"}],"prism:publicationName":[{"@value":"Journal of Functional Foods"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2018-06","prism:volume":"45","prism:startingPage":"417","prism:endingPage":"426"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1756464618301579?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1756464618301579?httpAccept=text/plain"}],"createdAt":"2018-04-21","modifiedAt":"2022-08-20","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20stress","dc:title":"Oxidative stress"},{"@id":"https://cir.nii.ac.jp/all?q=Nutrition.%20Foods%20and%20food%20supply","dc:title":"Nutrition. Foods and food supply"},{"@id":"https://cir.nii.ac.jp/all?q=Parkinson%E2%80%99s%20disease","dc:title":"Parkinson’s disease"},{"@id":"https://cir.nii.ac.jp/all?q=DHA-PS","dc:title":"DHA-PS"},{"@id":"https://cir.nii.ac.jp/all?q=DHA-PC","dc:title":"DHA-PC"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=TX341-641","dc:title":"TX341-641"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781906899840","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K00890"},{"@type":"JGN","@value":"JP16K00890"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K00890/"}],"notation":[{"@language":"ja","@value":"新規機能性脂質によるメタボリックシンドローム予防に関する研究"},{"@language":"en","@value":"Prevention of metabolic syndromes by novel functional lipids"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143586157824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tormentic acid in foods exerts anti-proliferation efficacy through inducing apoptosis and cell cycle arrest"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143915555200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhanced neuroprotective effect of DHA and EPA-enriched phospholipids against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced oxidative stress in mice brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145137360384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti‐apoptotic role of omega‐3‐fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145163373952","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145507840128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146372453376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286996862847360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat diet"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620060053632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Docosahexaenoic Acid Promotes Dopaminergic Differentiation in Induced Pluripotent Stem Cells and Inhibits Teratoma Formation in Rats with Parkinson-Like Pathology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621218573696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The protective mechanism of docosahexaenoic acid in mouse model of Parkinson: The role of heme oxygenase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905616274176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of short‐term supplementation with <scp>DHA</scp>‐enriched phosphatidylcholine and phosphatidylserine on lipid profiles in the brain and liver of n‐3 <scp>PUFA</scp>‐deficient mice in early life after weaning"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568468462128896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A pilot study on the effects of DHA/EPA-enriched phospholipids on aerobic and anaerobic exercises in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094772041216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modulation of brain-derived neurotrophic factor as a potential neuroprotective mechanism of action of omega-3 fatty acids in a parkinsonian animal model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360849943441697152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The rapid effects of eicosapentaenoic acid (EPA) enriched phospholipids on alleviating exercise fatigue in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569892694656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Renoprotective effect of fucoidan from Acaudina molpadioides in streptozotocin/high fat diet-induced type 2 diabetic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570199186560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential vulnerability of substantia nigra and corpus striatum to oxidative insult induced by reduced dietary levels of essential fatty acids"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571164786048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044017207552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045282299776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphatidylserine metabolism modification precedes manganese-induced apoptosis and phosphatidylserine exposure in PC12 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046379209856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhanced learning and memory of normal young rats by repeated oral administration of Krill Phosphatidylserine"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518835434240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biochemical aspects of the neuroprotective mechanism of PTEN‐induced kinase‐1 (PINK1)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519810583808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intracellular Antioxidant Detoxifying Effects of Diosmetin on 2,2-Azobis(2-amidinopropane) Dihydrochloride (AAPH)-Induced Oxidative Stress through Inhibition of Reactive Oxygen Species Generation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520017359360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modification by docosahexaenoic acid of age-induced alterations in gene expression and molecular composition of rat brain phospholipids"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993698788736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993780416384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Metformin protects primary rat hepatocytes against oxidative stress‐induced apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995891441408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468975829120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of a novel phospholipase D with high transphosphatidylation activity and its application in synthesis of phosphatidylserine and DHA-phosphatidylserine"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469421463424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Docosahexaenoic acid aggravates photooxidative damage in retinal pigment epithelial cells via lipid peroxidation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470753130368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Maternal Docosahexaenoic Acid Feeding Protects Against Impairment of Learning and Memory and Oxidative Stress in Prenatally Stressed Rats: Possible Role of Neuronal Mitochondria Metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470818879616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuronal Specific Increase of Phosphatidylserine by Docosahexaenoic Acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943866421632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The influence and the mechanism of docosahexaenoic acid on a mouse model of Parkinson’s disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944621126912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Swim-test as a function of motor impairment in MPTP model of Parkinson's disease: A comparative study in two mouse strains"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944730846592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945362835712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A REVIEW OF PHOSPHATIDYLSERINE PHARMACOLOGICAL AND CLINICAL EFFECTS. IS PHOSPHATIDYLSERINE A DRUG FOR THE AGEING BRAIN?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946119524224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-chain bases from sea cucumber mitigate endoplasmic reticulum stress and inflammation in obesity mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418372683264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Substrate Preference in Phosphatidylserine Biosynthesis for Docosahexaenoic Acid Containing Species"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418681955456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease."}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419023287424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"n−3 Fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419054765312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Parkinson's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419386740608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of Bax in quercetin-induced apoptosis in human prostate cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894641969664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Eicosapentaenoic acid-enriched phospholipids improve atherosclerosis by mediating cholesterol metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895284599296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Strategies for transporting nanoparticles across the blood–brain barrier"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895661831296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-chain bases from sea cucumber inhibits renal fibrosis and apoptosis in type 2 diabetic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369558562304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protective effect of docosahexaenoic acid against brain injury in ischemic rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369792824576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Partial neurorescue effects of DHA following a 6-OHDA lesion of the mouse dopaminergic system"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319090644608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DHA-PC and DHA-PS improved Aβ1–40 induced cognitive deficiency uncoupled with an increase in brain DHA in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319521185792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319667104128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phosphatidylserine in the brain: Metabolism and function"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320112319744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of action of docosahexaenoic acid in the nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320173566976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Short term effects of different omega-3 fatty acid formulation on lipid metabolism in mice fed high or low fat diet"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793323753600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Environmental toxins and Parkinson’s disease: Putative roles of impaired electron transport chain and oxidative stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269506385152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of Neuronal Apoptosis by Docosahexaenoic Acid (22:6n-3)"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269921524608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Highly Pure Phospholipids Based Brain Docosahexaenoic Acid Transporters"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679609451776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238024956928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"機能性油脂による脂肪肝予防と脳機能改善作用"},{"@language":"en","@value":"How functional lipids affect on fatty liver and brain function disorders"},{"@language":"ja-Kana","@value":"キノウセイ ユシ ニ ヨル シボウカン ヨボウ ト ノウ キノウ カイゼン サヨウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390865651897997696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Health Benefits of Dietary Docosahexaenoic Acid- and Eicosapentaenoic Acid-enriched Glycerophospholipids from Marine Sources"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.jff.2018.04.017"},{"@type":"KAKEN","@value":"PRODUCT-22005488"},{"@type":"OPENAIRE","@value":"doi_dedup___::35b9b2ec14a9814400baf956fdaf6f30"},{"@type":"CROSSREF","@value":"10.1186/s12944-020-01253-3_references_DOI_MFpg8CIjz9vyg1sGivUTQGyYzrI"},{"@type":"CROSSREF","@value":"10.5650/jos.ess24253_references_DOI_MFpg8CIjz9vyg1sGivUTQGyYzrI"},{"@type":"CROSSREF","@value":"10.1002/jsfa.13625_references_DOI_MFpg8CIjz9vyg1sGivUTQGyYzrI"},{"@type":"CROSSREF","@value":"10.1039/c9fo02489a_references_DOI_MFpg8CIjz9vyg1sGivUTQGyYzrI"},{"@type":"CROSSREF","@value":"10.1039/c9ra05181c_references_DOI_MFpg8CIjz9vyg1sGivUTQGyYzrI"},{"@type":"CROSSREF","@value":"10.4010/jln.27.171_references_DOI_MFpg8CIjz9vyg1sGivUTQGyYzrI"}]}