{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848657351012736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.parint.2014.10.007"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1383576914001433?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1383576914001433?httpAccept=text/xml"}},{"identifier":{"@type":"PMID","@value":"25449979"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Stage specific activity of synthetic antimalarial endoperoxides, N-89 and N-251, against Plasmodium falciparum"}],"description":[{"notation":[{"@value":"We have reported that two endoperoxides, N-89 and N-251, synthesized in 2001, possess potent antimalarial activities. Aiming at their eventual use for curing malaria in humans, we have been investigating various aspects of their antimalarial actions. Here we show that N-89 and N-251 inhibit the growth of Plasmodium falciparum within human erythrocytes in vitro at its lifecycle stage 'trophozoite' specifically. It is known that artemisinin compounds, which are currently used for curing malaria, have other stage-specificities. Therefore, it is likely that the antimalarial mechanism of N-89 and N-251 differs from those of artemisinin compounds. As malaria parasites resistant to artemisinin-based combination therapy are currently emerging in some tropical regions, N-89 and N-251 are candidates for overcoming these new problems."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326212026240","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60709632"},{"@type":"NRID","@value":"1000060709632"},{"@type":"NRID","@value":"9000414244496"},{"@type":"NRID","@value":"9000398802449"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000015290"}],"foaf:name":[{"@value":"Masayuki Morita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657351012742","@type":"Researcher","foaf:name":[{"@value":"Takahiko Koyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657351012736","@type":"Researcher","foaf:name":[{"@value":"Hitomi Sanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657351012741","@type":"Researcher","foaf:name":[{"@value":"Akira 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2-Ring"},{"@id":"https://cir.nii.ac.jp/all?q=Artemisinins","dc:title":"Artemisinins"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Resistance,%20Multiple","dc:title":"Drug Resistance, Multiple"},{"@id":"https://cir.nii.ac.jp/all?q=Malaria","dc:title":"Malaria"},{"@id":"https://cir.nii.ac.jp/all?q=Antimalarials","dc:title":"Antimalarials"},{"@id":"https://cir.nii.ac.jp/all?q=Parasitic%20Sensitivity%20Tests","dc:title":"Parasitic Sensitivity Tests"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Spiro%20Compounds","dc:title":"Spiro Compounds"},{"@id":"https://cir.nii.ac.jp/all?q=Trophozoites","dc:title":"Trophozoites"},{"@id":"https://cir.nii.ac.jp/all?q=Tetraoxanes","dc:title":"Tetraoxanes"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782247256704","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25305008"},{"@type":"JGN","@value":"JP25305008"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25305008/"}],"notation":[{"@language":"ja","@value":"西アフリカにまん延する風土病制御に向けた国際共同調査研究"},{"@language":"en","@value":"Joint Cooperative Research for Endemic Diseases Control in Ghana"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257294986752","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26860279"},{"@type":"JGN","@value":"JP26860279"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860279/"}],"notation":[{"@language":"ja","@value":"1900種の組換えマラリア原虫タンパク質を用いたワクチン候補抗原スクリーニング"},{"@language":"en","@value":"Genome-wide immunoscreening of 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