{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848657410349696.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.reth.2018.10.008"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2352320418300208?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2352320418300208?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"30671501"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Allogeneic multipotent mesenchymal stromal cell sheet transplantation promotes healthy healing of wounds caused by zoledronate and dexamethasone in canine mandibular bones"}],"description":[{"notation":[{"@value":"Many cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ), which is an intractable disease, have been reported. Although a general intravenous injection of multipotent mesenchymal stromal cells (MSCs) may be effective for treating BRONJ, it has some severe problems. Therefore, our aim was to develop a treatment of locally administered MSCs. In this study, we investigated the effect of MSC sheet transplantation in the mandibular bone healing in beagle dogs, which were administered zoledronate and dexamethasone.MSCs isolated from subcutaneous fat were seeded onto temperature-responsive culture dishes to produce MSC sheets. Zoledronate and dexamethasone were administered to beagle dogs. Then, the parts of mandibular cortical bones were removed, and MSC sheets were transplanted to cover those bone defects (MSC sheet transplant side) or not (Control side). The specimens were evaluated in micro CT, histology, and immunohistochemistry.Four weeks after surgery, redness and swellings were observed in the mucosal wounds of the control sides of 2 of 3 dogs. In contrast, the mucosal wounds of the MSC sheet transplant sides of all dogs completely healed. Histological images showed some free sequestrums and many bacterial colonies, and Immunohistological analysis showed some cathepsin K-positive multinuclear cells detached from jaw bone surfaces in the control sides.MSC sheet transplantation promotes healthy healing of wounds caused by zoledronate and dexamethasone in canine mandibular bones. And the injured canine mandibular bones administered zoledronate and dexamethasone showed BRONJ-like findings."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751140982400","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50621330"},{"@type":"NRID","@value":"1000050621330"},{"@type":"NRID","@value":"9000411524637"},{"@type":"NRID","@value":"9000405763485"},{"@type":"NRID","@value":"9000296661802"},{"@type":"NRID","@value":"9000312252415"},{"@type":"NRID","@value":"9000409631870"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kaibuchi.nobuyuki"}],"foaf:name":[{"@value":"Nobuyuki Kaibuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801188469504","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60431946"},{"@type":"NRID","@value":"1000060431946"},{"@type":"NRID","@value":"9000406390534"},{"@type":"NRID","@value":"9000413755903"},{"@type":"NRID","@value":"9000404539776"},{"@type":"NRID","@value":"9000004729152"},{"@type":"NRID","@value":"9000297473663"},{"@type":"NRID","@value":"9000411012815"},{"@type":"NRID","@value":"9000258310641"},{"@type":"NRID","@value":"9000241437755"},{"@type":"NRID","@value":"9000408912752"},{"@type":"NRID","@value":"9000411235389"},{"@type":"NRID","@value":"9000409523883"},{"@type":"NRID","@value":"9000414373788"},{"@type":"NRID","@value":"9000414726076"},{"@type":"NRID","@value":"9000409631525"},{"@type":"NRID","@value":"9000397447449"},{"@type":"NRID","@value":"9000397447409"},{"@type":"NRID","@value":"9000412282825"},{"@type":"NRID","@value":"9000387366349"},{"@type":"NRID","@value":"9000408593948"},{"@type":"NRID","@value":"9000409631876"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/iwatatakanori"}],"foaf:name":[{"@value":"Takanori Iwata"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657410349696","@type":"Researcher","foaf:name":[{"@value":"Satoru Onizuka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657410349826","@type":"Researcher","foaf:name":[{"@value":"Kosei Yano"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326235347072","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70726265"},{"@type":"NRID","@value":"1000070726265"},{"@type":"NRID","@value":"9000408593924"},{"@type":"NRID","@value":"9000018620879"},{"@type":"NRID","@value":"9000391768118"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000026111"}],"foaf:name":[{"@value":"Yuka Tsumanuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657410349829","@type":"Researcher","foaf:name":[{"@value":"Masayuki Yamato"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657410349828","@type":"Researcher","foaf:name":[{"@value":"Teruo Okano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657410349827","@type":"Researcher","foaf:name":[{"@value":"Tomohiro Ando"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"23523204"}],"prism:publicationName":[{"@value":"Regenerative Therapy"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2019-06","prism:volume":"10","prism:startingPage":"77","prism:endingPage":"83"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2352320418300208?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2352320418300208?httpAccept=text/plain"}],"createdAt":"2019-01-11","modifiedAt":"2025-11-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Medicine%20(General)","dc:title":"Medicine (General)"},{"@id":"https://cir.nii.ac.jp/all?q=R5-920","dc:title":"R5-920"},{"@id":"https://cir.nii.ac.jp/all?q=QH573-671","dc:title":"QH573-671"},{"@id":"https://cir.nii.ac.jp/all?q=Original%20Article","dc:title":"Original Article"},{"@id":"https://cir.nii.ac.jp/all?q=Cytology","dc:title":"Cytology"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781973796352","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K17346"},{"@type":"JGN","@value":"JP17K17346"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K17346/"}],"notation":[{"@language":"ja","@value":"同種の歯根膜細胞移植治療に向けた優れた再生能を有する細胞予測"},{"@language":"en","@value":"Prediction of cells indicating superior regenerative potential for allogeneic transplantation of periodontal ligament cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781993543680","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H02985"},{"@type":"JGN","@value":"JP18H02985"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02985/"}],"notation":[{"@language":"ja","@value":"ES細胞を基軸とした歯周組織再生担当細胞の分化制御メカニズムの解明"},{"@language":"en","@value":"Investigation of differentiation control from human embryonic stem cells to responsible cells for periodontal regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782005108864","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K17181"},{"@type":"JGN","@value":"JP18K17181"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K17181/"}],"notation":[{"@language":"ja","@value":"細胞シートによるBRONJの新規治療法の開発と次世代シーケンサーによる病態解明"},{"@language":"en","@value":"Novel treatment and clarifying pathophysiology of BRONJ using cell sheet engineering and next generation sequence"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142804330752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Design of Temperature-Responsive Cell Culture Surfaces for Cell Sheet Engineering"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143843626496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Factors influencing surgical 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