{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848657489358336.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.ygeno.2013.02.007"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0888754313000360?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0888754313000360?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"23485556"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling"}],"description":[{"notation":[{"@value":"Gene expression profiling of hepatocellular carcinoma (HCC) and background liver has been studied extensively; however, the relationship between the gene expression profiles of different lesions has not been assessed.We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV]-related and 17 hepatitis C virus [HCV]-related) and 71 non-tumor liver specimens (36 chronic hepatitis B [CH-B] and 35 chronic hepatitis C [CH-C]) using an in-house cDNA microarray consisting of liver-predominant genes. Graphical Gaussian modeling (GGM) was applied to elucidate the interactions of gene clusters among the HCC and non-tumor lesions.In CH-B-related HCC, the expression of vascular endothelial growth factor-family signaling and regulation of T cell differentiation, apoptosis, and survival, as well as development-related genes was up-regulated. In CH-C-related HCC, the expression of ectodermal development and cell proliferation, wnt receptor signaling, cell adhesion, and defense response genes was also up-regulated. Many of the metabolism-related genes were down-regulated in both CH-B- and CH-C-related HCC. GGM analysis of the HCC and non-tumor lesions revealed that DNA damage response genes were associated with AP1 signaling in non-tumor lesions, which mediates the expression of many genes in CH-B-related HCC. In contrast, signal transducer and activator of transcription 1 and phosphatase and tensin homolog were associated with early growth response protein 1 signaling in non-tumor lesions, which potentially promotes angiogenesis, fibrogenesis, and tumorigenesis in CH-C-related HCC.Gene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030566608850838400","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80600741"},{"@type":"NRID","@value":"1000080600741"},{"@type":"NRID","@value":"9000396129446"},{"@type":"NRID","@value":"9000023232511"},{"@type":"NRID","@value":"9000010547238"},{"@type":"NRID","@value":"9000243890264"},{"@type":"NRID","@value":"9000350631608"}],"foaf:name":[{"@value":"Teruyuki 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Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326211947264","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60613734"},{"@type":"NRID","@value":"1000060613734"},{"@type":"NRID","@value":"9000367031922"},{"@type":"NRID","@value":"9000237898608"},{"@type":"NRID","@value":"9000406042500"},{"@type":"NRID","@value":"9000392782669"},{"@type":"NRID","@value":"9000001972440"},{"@type":"NRID","@value":"9000345405820"},{"@type":"NRID","@value":"9000258558659"},{"@type":"NRID","@value":"9000001089795"},{"@type":"NRID","@value":"9000409578446"},{"@type":"NRID","@value":"9000242089287"},{"@type":"NRID","@value":"9000263044162"},{"@type":"NRID","@value":"9000237898483"},{"@type":"NRID","@value":"9000414820279"},{"@type":"NRID","@value":"9000401431778"},{"@type":"NRID","@value":"9000398985204"},{"@type":"NRID","@value":"9000361229897"},{"@type":"NRID","@value":"9000286622367"},{"@type":"NRID","@value":"9000001386018"},{"@type":"NRID","@value":"9000409587556"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000006735"}],"foaf:name":[{"@value":"Hajime Takatori"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133838882688","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90595836"},{"@type":"NRID","@value":"1000090595836"},{"@type":"NRID","@value":"9000018468044"},{"@type":"NRID","@value":"9000023579758"},{"@type":"NRID","@value":"9000237912746"}],"foaf:name":[{"@value":"Hajime Sunagozaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848657489358337","@type":"Researcher","foaf:name":[{"@value":"Shuichi Kaneko"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08887543"}],"prism:publicationName":[{"@value":"Genomics"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2013-04","prism:volume":"101","prism:number":"4","prism:startingPage":"238","prism:endingPage":"248"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0888754313000360?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0888754313000360?httpAccept=text/plain"}],"createdAt":"2013-02-25","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Hepatocellular","dc:title":"Carcinoma, Hepatocellular"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription,%20Genetic","dc:title":"Transcription, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Normal%20Distribution","dc:title":"Normal Distribution"},{"@id":"https://cir.nii.ac.jp/all?q=Genetics","dc:title":"Genetics"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Adhesion","dc:title":"Cell Adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Wnt%20Signaling%20Pathway","dc:title":"Wnt Signaling Pathway"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Early%20Growth%20Response%20Protein%201","dc:title":"Early Growth Response Protein 1"},{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Genetic","dc:title":"Models, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Vascular%20Endothelial%20Growth%20Factors","dc:title":"Vascular Endothelial Growth Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Profiling","dc:title":"Gene Expression Profiling"},{"@id":"https://cir.nii.ac.jp/all?q=Liver%20Neoplasms","dc:title":"Liver Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20B","dc:title":"Hepatitis B"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatitis%20C","dc:title":"Hepatitis C"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Neoplastic","dc:title":"Gene Expression Regulation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=STAT1%20Transcription%20Factor","dc:title":"STAT1 Transcription Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Damage","dc:title":"DNA Damage"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782180195712","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23701098"},{"@type":"JGN","@value":"JP23701098"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23701098/"}],"notation":[{"@language":"ja","@value":"遺伝子発現プロファイルを用いた肝細胞癌治療における新規バイオマーカーの同定"},{"@language":"en","@value":"Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma."}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782204193024","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24510285"},{"@type":"JGN","@value":"JP24510285"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24510285/"}],"notation":[{"@language":"ja","@value":"構造方程式モデリングによる多能性幹細胞での細胞分化制御因子の推定"},{"@language":"en","@value":"Inference of cell differentiation factors in pluripotent cells by Structural Equation Modelling"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782230318976","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24790686"},{"@type":"JGN","@value":"JP24790686"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790686/"}],"notation":[{"@language":"ja","@value":"ウイルス性慢性肝疾患からの発癌に関わるマイクロＲＮＡの探索"},{"@language":"en","@value":"Micro RNA expressions of chronic hepatitis related hepatocellular carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257176882432","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24390187"},{"@type":"JGN","@value":"JP24390187"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390187/"}],"notation":[{"@language":"ja","@value":"Ｃ型慢性肝炎治療成績の向上と肝発癌阻止を目指した分子基盤の確立"},{"@language":"en","@value":"Establishment of molecular basis for improving the treatment efficacy of chronic hepatitis C and preventing the occurrence of hepatocellular carcinoma."}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257202512896","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24701024"},{"@type":"JGN","@value":"JP24701024"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24701024/"}],"notation":[{"@language":"ja","@value":"ｄＵＴＰａｓｅとｗｎｔシグナルを標的とした肝細胞癌新規治療薬の開発"},{"@language":"en","@value":"development of hepatocellular carcinoma novel therapeutics that target wnt signaling and dUTPase"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050845760881209728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760883977216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential interferon signaling in cells in 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