{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848658342115456.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/jid.2015.318"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0022202X1560166X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0022202X1560166X?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"26288354"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"TSLP Directly Interacts with Skin-Homing Th2 Cells Highly Expressing its Receptor to Enhance IL-4 Production in Atopic Dermatitis"}],"description":[{"notation":[{"@value":"Thymic stromal lymphopoietin (TSLP) is overtly expressed on skin lesions of atopic dermatitis (AD), and the initiative role of TSLP-activated DCs in AD has gained much attention in the past few years, while its actions on other immune cells such as T cells have been given less notice. We aimed to clarify whether TSLP receptor (TSLPR) is expressed on certain populations of T cells and whether TSLP possesses the capability to directly interact with T cells from AD patients. Peripheral lymphocytes from 51 AD patients are analyzed by flow cytometry, and ex vivo experiments using peripheral blood and lesional skin-derived T cells were conducted. TSLPR expression was defined to CD4+ T cells, and CD4+CCR4+CXCR3-CCR7-CCR10+CLA+ T cells in AD patients exhibited enhanced TSLPR expression. The frequency of TSLPR+CD4+ T cells correlated with disease activity. CD4+ T cells from AD patients directly interacted with TSLP to produce a higher amount of IL-4 than those from normal subjects, and this action was attenuated with anti-TSLPR antibody. The importance of IL-4 in the induction of TSLPR expression was found in AD T cells. Our findings indicate that T cells from AD patients possess strong potential to directly interact with TSLP to promote Th2 response."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848658342115456","@type":"Researcher","foaf:name":[{"@value":"Kazuki Tatsuno"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848658342115460","@type":"Researcher","foaf:name":[{"@value":"Toshiharu Fujiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848658342115457","@type":"Researcher","foaf:name":[{"@value":"Hayato Yamaguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848658342115458","@type":"Researcher","foaf:name":[{"@value":"Michihiko Waki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848658342115459","@type":"Researcher","foaf:name":[{"@value":"Yoshiki Tokura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0022202X"}],"prism:publicationName":[{"@value":"Journal of Investigative Dermatology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2015-12","prism:volume":"135","prism:number":"12","prism:startingPage":"3017","prism:endingPage":"3024"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0022202X1560166X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0022202X1560166X?httpAccept=text/plain"}],"createdAt":"2015-08-19","modifiedAt":"2025-04-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=CD4-Positive%20T-Lymphocytes","dc:title":"CD4-Positive T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20CCR4","dc:title":"Receptors, CCR4"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Antigen,%20T-Cell","dc:title":"Receptors, Antigen, T-Cell"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoglobulins","dc:title":"Immunoglobulins"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Biology","dc:title":"Cell Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Dermatology","dc:title":"Dermatology"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoglobulin%20E","dc:title":"Immunoglobulin E"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Activation","dc:title":"Lymphocyte Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Biochemistry","dc:title":"Biochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Dermatitis,%20Atopic","dc:title":"Dermatitis, Atopic"},{"@id":"https://cir.nii.ac.jp/all?q=Th2%20Cells","dc:title":"Th2 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Thymic%20Stromal%20Lymphopoietin","dc:title":"Thymic Stromal Lymphopoietin"},{"@id":"https://cir.nii.ac.jp/all?q=Cytokines","dc:title":"Cytokines"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Chemokine%20CCL17","dc:title":"Chemokine CCL17"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-4","dc:title":"Interleukin-4"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Cytokine","dc:title":"Receptors, Cytokine"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=Skin","dc:title":"Skin"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257289563392","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26670524"},{"@type":"JGN","@value":"JP26670524"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670524/"}],"notation":[{"@language":"ja","@value":"非侵襲的採取角層を用いたプロテオーム解析によるアトピー性皮膚炎バリア異常の評価"},{"@language":"en","@value":"Proteome analysis of stratum corneum from atopic dermatitis patients using non-invasive tape-stripping method."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050845760661994880","@type":"Article","resourceType":"学術雑誌論文(journal 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