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Beclin 1 regulates recycling endosome and is required for skin development in mice
Bibliographic Information
- Published
- 2019-01-25
- Resource Type
- journal article
- Rights Information
-
- https://creativecommons.org/licenses/by/4.0
- https://creativecommons.org/licenses/by/4.0
- DOI
-
- 10.1038/s42003-018-0279-0
- Publisher
- Springer Science and Business Media LLC
Description
<jats:title>Abstract</jats:title><jats:p>Beclin 1 is a key regulator of autophagy and endocytosis. However, its autophagy-independent functions remain poorly understood. Here, we report that Beclin 1 regulates recycling endosome and is required for skin development in vivo. We first established keratinocyte-specific Beclin 1-knockout mice and found that these mutant mice died owing to severe impairment of epidermal barrier. Beclin 1 plays a role in autophagy and the endocytic pathway in cooperation with Atg14 and UVRAG, respectively, and keratinocyte-specific Atg14-knockout mice do not show any abnormal phenotypes, suggesting that Beclin 1 has a role in skin development via the endocytic pathway. Furthermore, we found that Beclin 1 deficiency causes mislocalization of integrins via a defect of recycling endosome, abnormal cell detachment of basal cells and their immature differentiation, and abnormal skin development. These results provide the first genetic evidence showing the roles of Beclin 1 in recycling endosome and skin development.</jats:p>
Journal
-
- Communications Biology
-
Communications Biology 2 (1), 37-, 2019-01-25
Springer Science and Business Media LLC
