{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848658463537664.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/srep22223"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/srep22223"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/srep22223.pdf"}},{"identifier":{"@type":"PMID","@value":"26927695"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Significant impact of miRNA–target gene networks on genetics of human complex traits"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The impact of microRNA (miRNA) on the genetics of human complex traits, especially in the context of miRNA-target gene networks, has not been fully assessed. Here, we developed a novel analytical method, MIGWAS, to comprehensively evaluate enrichment of genome-wide association study (GWAS) signals in miRNA–target gene networks. We applied the method to the GWAS results of the 18 human complex traits from >1.75 million subjects and identified significant enrichment in rheumatoid arthritis (RA), kidney function and adult height (<jats:italic>P </jats:italic>< 0.05/18= 0.0028, most significant enrichment in RA with <jats:italic>P </jats:italic>= 1.7 × 10<jats:sup>−4</jats:sup>). Interestingly, these results were consistent with current literature-based knowledge of the traits on miRNA obtained through the NCBI PubMed database search (adjusted <jats:italic>P </jats:italic>= 0.024). Our method provided a list of miRNA and target gene pairs with excess genetic association signals, part of which included drug target genes. We identified a miRNA (miR-4728-5p) that downregulates <jats:italic>PADI2</jats:italic>, a novel RA risk gene considered as a promising therapeutic target (rs761426, adjusted <jats:italic>P </jats:italic>= 2.3 × 10<jats:sup>−9</jats:sup>). Our study indicated the significant impact of miRNA–target gene networks on the genetics of human complex traits and provided resources which should contribute to drug discovery and nucleic acid medicine.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326235354496","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70727411"},{"@type":"NRID","@value":"1000070727411"},{"@type":"ORCID","@value":"0000-0002-0311-8472"},{"@type":"CINII_AUTHOR_ID","@value":"DA19020604"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA19020604#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA19020604"},{"@type":"NRID","@value":"9000322108952"},{"@type":"NRID","@value":"9000292870305"},{"@type":"NRID","@value":"9000411522584"},{"@type":"NRID","@value":"9000017152653"},{"@type":"NRID","@value":"9000018877304"},{"@type":"NRID","@value":"9000405645892"},{"@type":"NRID","@value":"9000409835555"},{"@type":"NRID","@value":"9000409990028"},{"@type":"NRID","@value":"9000259843075"},{"@type":"NRID","@value":"9000414385960"},{"@type":"NRID","@value":"9000365492737"},{"@type":"NRID","@value":"9000356656458"},{"@type":"NRID","@value":"9000308727603"},{"@type":"NRID","@value":"9000331883139"},{"@type":"NRID","@value":"9000399595658"},{"@type":"NRID","@value":"9000413509719"},{"@type":"NRID","@value":"9000331448805"},{"@type":"NRID","@value":"9000399539607"},{"@type":"NRID","@value":"9000411992745"},{"@type":"NRID","@value":"9000402899508"},{"@type":"NRID","@value":"9000391689583"},{"@type":"NRID","@value":"9000405927748"},{"@type":"NRID","@value":"9000342797621"},{"@type":"NRID","@value":"9000345303360"},{"@type":"NRID","@value":"9000309181013"},{"@type":"NRID","@value":"9000398779793"},{"@type":"NRID","@value":"9000410497014"},{"@type":"NRID","@value":"9000292869864"},{"@type":"NRID","@value":"9000412339945"},{"@type":"NRID","@value":"9000327104560"},{"@type":"NRID","@value":"9000411800350"},{"@type":"NRID","@value":"9000009986242"},{"@type":"NRID","@value":"9000290815990"},{"@type":"NRID","@value":"9000387476402"},{"@type":"NRID","@value":"9000019185804"},{"@type":"NRID","@value":"9000021892803"},{"@type":"NRID","@value":"9000265248564"},{"@type":"NRID","@value":"9000411000436"},{"@type":"NRID","@value":"9000411202693"},{"@type":"NRID","@value":"9000405673625"},{"@type":"NRID","@value":"9000336384499"},{"@type":"NRID","@value":"9000399532395"},{"@type":"NRID","@value":"9000340953110"},{"@type":"NRID","@value":"9000408632021"},{"@type":"NRID","@value":"9000402817299"},{"@type":"NRID","@value":"9000410266700"},{"@type":"NRID","@value":"9000309181065"},{"@type":"NRID","@value":"9000301744092"},{"@type":"NRID","@value":"9000410482819"},{"@type":"NRID","@value":"9000405645736"},{"@type":"NRID","@value":"9000334740715"},{"@type":"NRID","@value":"9000408479719"},{"@type":"NRID","@value":"9000412284981"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/yokada"}],"foaf:name":[{"@value":"Yukinori 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LLC"}],"prism:publicationDate":"2016-03-01","prism:volume":"6","prism:number":"1","prism:startingPage":"22223"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","invited":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/srep22223"},{"@id":"https://www.nature.com/articles/srep22223.pdf"}],"createdAt":"2016-03-01","modifiedAt":"2023-01-04","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Risk","dc:title":"Risk"},{"@id":"https://cir.nii.ac.jp/all?q=Multifactorial%20Inheritance","dc:title":"Multifactorial Inheritance"},{"@id":"https://cir.nii.ac.jp/all?q=Hydrolases","dc:title":"Hydrolases"},{"@id":"https://cir.nii.ac.jp/all?q=Down-Regulation","dc:title":"Down-Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney","dc:title":"Kidney"},{"@id":"https://cir.nii.ac.jp/all?q=Polymorphism,%20Single%20Nucleotide","dc:title":"Polymorphism, Single Nucleotide"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Body%20Height","dc:title":"Body Height"},{"@id":"https://cir.nii.ac.jp/all?q=Arthritis,%20Rheumatoid","dc:title":"Arthritis, Rheumatoid"},{"@id":"https://cir.nii.ac.jp/all?q=MicroRNAs","dc:title":"MicroRNAs"},{"@id":"https://cir.nii.ac.jp/all?q=Protein-Arginine%20Deiminase%20Type%202","dc:title":"Protein-Arginine Deiminase Type 2"},{"@id":"https://cir.nii.ac.jp/all?q=Protein-Arginine%20Deiminases","dc:title":"Protein-Arginine Deiminases"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Regulatory%20Networks","dc:title":"Gene Regulatory Networks"},{"@id":"https://cir.nii.ac.jp/all?q=Genetic%20Predisposition%20to%20Disease","dc:title":"Genetic Predisposition to Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Targeted%20Therapy","dc:title":"Molecular Targeted Therapy"},{"@id":"https://cir.nii.ac.jp/all?q=Genome-Wide%20Association%20Study","dc:title":"Genome-Wide Association Study"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781834373248","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H05908"},{"@type":"JGN","@value":"JP15H05908"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-15H05908/"}],"notation":[{"@language":"ja","@value":"がん細胞文脈のシステム的統合理解による新たながん診断・治療概念の確立"},{"@language":"en","@value":"Establishment of novel concept for cancer diagnostics and therapeutics based on the systematic 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