{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848660438771072.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/ejn.12682"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fejn.12682"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/ejn.12682"}},{"identifier":{"@type":"PMID","@value":"25131300"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The glutamate receptor <scp>G</scp>lu<scp>N</scp>2 subunit regulates synaptic trafficking of <scp>AMPA</scp> receptors in the neonatal mouse brain"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The <jats:italic>N</jats:italic>‐methyl‐<jats:sc>d</jats:sc>‐aspartate receptor (<jats:styled-content style=\"fixed-case\">NMDAR</jats:styled-content>) plays various physiological and pathological roles in neural development, synaptic plasticity and neuronal cell death. It is composed of two <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>1 and two <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2 subunits and, in the neonatal hippocampus, most synaptic <jats:styled-content style=\"fixed-case\">NMDAR</jats:styled-content>s are <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">B</jats:styled-content>‐containing receptors, which are gradually replaced with <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">A</jats:styled-content>‐containing receptors during development. Here, we examined whether <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">A</jats:styled-content> could be substituted for <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">B</jats:styled-content> in neural development and functions by analysing knock‐in (<jats:styled-content style=\"fixed-case\">KI</jats:styled-content>) mice in which <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">B</jats:styled-content> is replaced with <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">A</jats:styled-content>. The <jats:styled-content style=\"fixed-case\">KI</jats:styled-content> mutation was neonatally lethal, although <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">A</jats:styled-content>‐containing receptors were transported to the postsynaptic membrane even without <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">B</jats:styled-content> and functional at synapses of acute hippocampal slices of postnatal day 0, indicating that <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">A</jats:styled-content>‐containing <jats:styled-content style=\"fixed-case\">NMDAR</jats:styled-content>s could not be substituted for <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">B</jats:styled-content>‐containing <jats:styled-content style=\"fixed-case\">NMDAR</jats:styled-content>s. Importantly, the synaptic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid receptor (<jats:styled-content style=\"fixed-case\">AMPAR</jats:styled-content>) subunit <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">A</jats:styled-content>1 was increased, and the transmembrane <jats:styled-content style=\"fixed-case\">AMPAR</jats:styled-content> regulatory protein, which is involved in <jats:styled-content style=\"fixed-case\">AMPAR</jats:styled-content> synaptic trafficking, was increased in <jats:styled-content style=\"fixed-case\">KI</jats:styled-content> mice. Although the regulation of <jats:styled-content style=\"fixed-case\">AMPAR</jats:styled-content>s by <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">B</jats:styled-content> has been reported in cultured neurons, we showed here that <jats:styled-content style=\"fixed-case\">AMPAR</jats:styled-content>‐mediated synaptic responses were increased in acute <jats:styled-content style=\"fixed-case\">KI</jats:styled-content> slices, suggesting differential roles of <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\">A</jats:styled-content> and <jats:styled-content style=\"fixed-case\">G</jats:styled-content>lu<jats:styled-content style=\"fixed-case\">N</jats:styled-content>2<jats:styled-content style=\"fixed-case\"> ..."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751167708544","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90755464"},{"@type":"NRID","@value":"1000090755464"},{"@type":"NRID","@value":"9000304977368"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000024883"}],"foaf:name":[{"@value":"Shun Hamada"}],"jpcoar:affiliationName":[{"@value":"Division of Neuronal Network Institute of Medical Science University of Tokyo Tokyo 108‐8639 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848660438771073","@type":"Researcher","foaf:name":[{"@value":"Itone Ogawa"}],"jpcoar:affiliationName":[{"@value":"Division of Neuronal Network Institute of Medical Science University of Tokyo Tokyo 108‐8639 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751136320768","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10431305"},{"@type":"NRID","@value":"1000010431305"},{"@type":"NRID","@value":"9000282391149"},{"@type":"NRID","@value":"9000023634799"},{"@type":"NRID","@value":"9000413480422"},{"@type":"NRID","@value":"9000017200245"},{"@type":"NRID","@value":"9000024427241"},{"@type":"NRID","@value":"9000022534215"},{"@type":"NRID","@value":"9000331444960"},{"@type":"NRID","@value":"9000410510194"},{"@type":"NRID","@value":"9000024168875"},{"@type":"NRID","@value":"9000383205231"},{"@type":"NRID","@value":"9000370253570"},{"@type":"NRID","@value":"9000024446149"},{"@type":"NRID","@value":"9000333924102"},{"@type":"NRID","@value":"9000019139319"},{"@type":"NRID","@value":"9000018608590"},{"@type":"NRID","@value":"9000278499419"},{"@type":"NRID","@value":"9000022766222"},{"@type":"NRID","@value":"9000024430684"},{"@type":"NRID","@value":"9000237782028"},{"@type":"NRID","@value":"9000238353111"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/potsuzo"}],"foaf:name":[{"@value":"Miwako Yamasaki"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy Hokkaido University Graduate School of Medicine Sapporo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848660438771459","@type":"Researcher","foaf:name":[{"@value":"Yuji Kiyama"}],"jpcoar:affiliationName":[{"@value":"Division of Neuronal Network Institute of Medical Science University of Tokyo Tokyo 108‐8639 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848660438771207","@type":"Researcher","foaf:name":[{"@value":"Hidetoshi Kassai"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Animal Resources Center for Disease Biology and Integrative Medicine Faculty of Medicine University of Tokyo Tokyo Japan"},{"@value":"Division of Molecular Genetics Kobe University Graduate School of Medicine Kobe Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848660438771466","@type":"Researcher","foaf:name":[{"@value":"Ayako M. 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