{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848660745358336.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/pin.12385"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpin.12385"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/pin.12385"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pin.12385"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1111/pin.12385"}},{"identifier":{"@type":"PMID","@value":"26811109"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Translational research on influenza virus infection using a nonhuman primate model"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Influenza virus infection is a seasonal infectious disease for humans, whereas it is also a zoonosis that is originally transmitted from animals to humans. Therefore, several animal models are used in research on influenza virus infection. We have used a nonhuman primate (<jats:styled-content style=\"fixed-case\">NHP</jats:styled-content>) model to extrapolate pathogenicity of various influenza viruses and efficacy of vaccines and antiviral drugs against the influenza viruses in humans. <jats:styled-content style=\"fixed-case\">NHP</jats:styled-content>s have genes, anatomical structure, and immune responses similar to those of humans as compared to other animal models. Using an <jats:styled-content style=\"fixed-case\">NHP</jats:styled-content> model, we revealed that the pandemic 2009 influenza <jats:styled-content style=\"fixed-case\">A</jats:styled-content> virus caused viral pneumonia as reported in human patients. Thus, it is thought that <jats:styled-content style=\"fixed-case\">NHP</jats:styled-content> models can be used to predict replication of emerging viruses in humans. We also examined the pathogenicity of highly pathogenic avian influenza viruses and evaluated a new therapeutic antibody in macaques under an immunocompromised condition. <jats:styled-content style=\"fixed-case\">NHP</jats:styled-content> models have provided promising results in research on other infectious diseases including <jats:styled-content style=\"fixed-case\">E</jats:styled-content>bola virus and human/simian immunodeficiency virus infections. Thus, <jats:styled-content style=\"fixed-case\">NHP</jats:styled-content>s are important in biomedical research for determining the pathogenesis and for development of treatments, especially when clinical trials are difficult. We summarize the characteristics and advantages of research using <jats:styled-content style=\"fixed-case\">NHP</jats:styled-content> models in this review.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848660745358083","@type":"Researcher","foaf:name":[{"@value":"Yasushi Itoh"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology Shiga University of Medical Science  Otsu Shiga Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13205463"},{"@type":"EISSN","@value":"14401827"}],"prism:publicationName":[{"@value":"Pathology International"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-01-26","prism:volume":"66","prism:number":"3","prism:startingPage":"132","prism:endingPage":"141"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#am","http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fpin.12385"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/pin.12385"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pin.12385"},{"@id":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1111/pin.12385"}],"createdAt":"2016-01-26","modifiedAt":"2023-09-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Birds","dc:title":"Birds"},{"@id":"https://cir.nii.ac.jp/all?q=Translational%20Research,%20Biomedical","dc:title":"Translational Research, Biomedical"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Macaca%20fascicularis","dc:title":"Macaca fascicularis"},{"@id":"https://cir.nii.ac.jp/all?q=Influenza%20A%20virus","dc:title":"Influenza A virus"},{"@id":"https://cir.nii.ac.jp/all?q=Influenza%20Vaccines","dc:title":"Influenza Vaccines"},{"@id":"https://cir.nii.ac.jp/all?q=Influenza%20in%20Birds","dc:title":"Influenza in Birds"},{"@id":"https://cir.nii.ac.jp/all?q=Influenza,%20Human","dc:title":"Influenza, Human"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256808288512","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H04720"},{"@type":"JGN","@value":"JP15H04720"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04720/"}],"notation":[{"@language":"ja","@value":"霊長類モデルを用いたインフルエンザ感染重症化宿主因子の探索"},{"@language":"en","@value":"Search for host factors in severe 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