{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848660919087360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/jvi.07077-11"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/JVI.07077-11"}},{"identifier":{"@type":"PMID","@value":"22491464"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Association of Major Histocompatibility Complex Class I Haplotypes with Disease Progression after Simian Immunodeficiency Virus Challenge in Burmese Rhesus Macaques"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title><jats:p>Nonhuman primate AIDS models are essential for the analysis of AIDS pathogenesis and the evaluation of vaccine efficacy. Multiple studies on human immunodeficiency virus and simian immunodeficiency virus (SIV) infection have indicated the association of major histocompatibility complex class I (MHC-I) genotypes with rapid or slow AIDS progression. The accumulation of macaque groups that share not only a single MHC-I allele but also an MHC-I haplotype consisting of multiple polymorphic MHC-I loci would greatly contribute to the progress of AIDS research. Here, we investigated SIVmac239 infections in four groups of Burmese rhesus macaques sharing individual MHC-I haplotypes, referred to as A, E, B, and J. Out of 20 macaques belonging to A<jats:sup>+</jats:sup>(<jats:italic>n</jats:italic>= 6), E<jats:sup>+</jats:sup>(<jats:italic>n</jats:italic>= 6), B<jats:sup>+</jats:sup>(<jats:italic>n</jats:italic>= 4), and J<jats:sup>+</jats:sup>(<jats:italic>n</jats:italic>= 4) groups, 18 showed persistent viremia. Fifteen of them developed AIDS in 0.5 to 4 years, with the remaining three at 1 or 2 years under observation. A<jats:sup>+</jats:sup>animals, including two controllers, showed slower disease progression, whereas J<jats:sup>+</jats:sup>animals exhibited rapid progression. E<jats:sup>+</jats:sup>and B<jats:sup>+</jats:sup>animals showed intermediate plasma viral loads and survival periods. Gag-specific CD8<jats:sup>+</jats:sup>T-cell responses were efficiently induced in A<jats:sup>+</jats:sup>animals, while Nef-specific CD8<jats:sup>+</jats:sup>T-cell responses were in A<jats:sup>+</jats:sup>, E<jats:sup>+</jats:sup>, and B<jats:sup>+</jats:sup>animals. Multiple comparisons among these groups revealed significant differences in survival periods, peripheral CD4<jats:sup>+</jats:sup>T-cell decline, and SIV-specific CD4<jats:sup>+</jats:sup>T-cell polyfunctionality in the chronic phase. This study indicates the association of MHC-I haplotypes with AIDS progression and presents an AIDS model facilitating the analysis of virus-host immune interaction.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801190958720","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80711001"},{"@type":"NRID","@value":"1000080711001"},{"@type":"NRID","@value":"9000367024489"},{"@type":"NRID","@value":"9000257924484"},{"@type":"NRID","@value":"9000367831392"},{"@type":"NRID","@value":"9000325834340"},{"@type":"NRID","@value":"9000017381824"},{"@type":"NRID","@value":"9000314379565"},{"@type":"NRID","@value":"9000024427085"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000017069"}],"foaf:name":[{"@value":"Takushi Nomura"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"},{"@value":"The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885697","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Yamamoto"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885842","@type":"Researcher","foaf:name":[{"@value":"Naofumi Takahashi"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"},{"@value":"The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885848","@type":"Researcher","foaf:name":[{"@value":"Teiichiro Shiino"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885853","@type":"Researcher","foaf:name":[{"@value":"Taku Nakane"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"},{"@value":"The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885827","@type":"Researcher","foaf:name":[{"@value":"Nami Iwamoto"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"},{"@value":"The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751144442496","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80750223"},{"@type":"NRID","@value":"1000080750223"},{"@type":"NRID","@value":"9000410174942"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000017078"}],"foaf:name":[{"@value":"Tetsuo Tsukamoto"}],"jpcoar:affiliationName":[{"@value":"The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885829","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Ishii"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"},{"@value":"The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885844","@type":"Researcher","foaf:name":[{"@value":"Miki Kawada"}],"jpcoar:affiliationName":[{"@value":"The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885850","@type":"Researcher","foaf:name":[{"@value":"Saori Matsuoka"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276175228544","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50469954"},{"@type":"NRID","@value":"1000050469954"},{"@type":"NRID","@value":"9000001251824"},{"@type":"NRID","@value":"9000254145545"},{"@type":"NRID","@value":"9000010138474"},{"@type":"NRID","@value":"9000411820561"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0118794"}],"foaf:name":[{"@value":"Kazutaka Terahara"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885854","@type":"Researcher","foaf:name":[{"@value":"Yasuko Tsunetsugu-Yokota"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885704","@type":"Researcher","foaf:name":[{"@value":"Akiko Takeda"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885696","@type":"Researcher","foaf:name":[{"@value":"Naoko Iwata-Yoshikawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885839","@type":"Researcher","foaf:name":[{"@value":"Hideki Hasegawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885840","@type":"Researcher","foaf:name":[{"@value":"Taeko K. Naruse"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Kandasurugadai, Chiyoda-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885698","@type":"Researcher","foaf:name":[{"@value":"Akinori Kimura"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Kandasurugadai, Chiyoda-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276158231168","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00270653"},{"@type":"NRID","@value":"1000000270653"},{"@type":"NRID","@value":"9000018386446"},{"@type":"NRID","@value":"9000001853197"},{"@type":"NRID","@value":"9000399220289"},{"@type":"NRID","@value":"9000254062716"},{"@type":"NRID","@value":"9000367024501"},{"@type":"NRID","@value":"9000257924485"},{"@type":"NRID","@value":"9000018212875"},{"@type":"NRID","@value":"9000018214522"},{"@type":"NRID","@value":"9000001259091"},{"@type":"NRID","@value":"9000409028887"},{"@type":"NRID","@value":"9000238241984"},{"@type":"NRID","@value":"9000411259388"},{"@type":"NRID","@value":"9000009567440"},{"@type":"NRID","@value":"9000325834346"},{"@type":"NRID","@value":"9000024105659"},{"@type":"NRID","@value":"9000410642372"},{"@type":"NRID","@value":"9000017692786"},{"@type":"NRID","@value":"9000386103623"},{"@type":"NRID","@value":"9000242684339"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0118328"}],"foaf:name":[{"@value":"Tetsuro Matano"}],"jpcoar:affiliationName":[{"@value":"AIDS Research Center, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"},{"@value":"The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380288215369885852","@type":"Researcher","foaf:name":[{"@value":"Tetsutaro Sata"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0022538X"},{"@type":"EISSN","@value":"10985514"}],"prism:publicationName":[{"@value":"Journal of Virology"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2012-06-15","prism:volume":"86","prism:number":"12","prism:startingPage":"6481","prism:endingPage":"6490"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/JVI.07077-11"}],"createdAt":"2012-04-06","modifiedAt":"2023-06-21","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Histocompatibility%20Antigens%20Class%20I","dc:title":"Histocompatibility Antigens Class I"},{"@id":"https://cir.nii.ac.jp/all?q=Simian%20Acquired%20Immunodeficiency%20Syndrome","dc:title":"Simian Acquired Immunodeficiency Syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=HIV%20Infections","dc:title":"HIV Infections"},{"@id":"https://cir.nii.ac.jp/all?q=CD8-Positive%20T-Lymphocytes","dc:title":"CD8-Positive T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Macaca%20mulatta","dc:title":"Macaca mulatta"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Haplotypes","dc:title":"Haplotypes"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Progression","dc:title":"Disease Progression"},{"@id":"https://cir.nii.ac.jp/all?q=HIV-1","dc:title":"HIV-1"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Simian%20Immunodeficiency%20Virus","dc:title":"Simian Immunodeficiency Virus"},{"@id":"https://cir.nii.ac.jp/all?q=Alleles","dc:title":"Alleles"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782152315648","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23390115"},{"@type":"JGN","@value":"JP23390115"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390115/"}],"notation":[{"@language":"ja","@value":"エイズウイルス複製制御個体で誘導される細胞性免疫反応の解析"},{"@language":"en","@value":"Cellular immune responses in AIDS virus controllers"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257113132800","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22790444"},{"@type":"JGN","@value":"JP22790444"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790444/"}],"notation":[{"@language":"ja","@value":"SARS-CoVに対する不活化ワクチンの副反応機序の解明とその改善について"},{"@language":"en","@value":"Study for side effects of inactivated SARS-CoV vaccine."}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257161867392","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23790453"},{"@type":"JGN","@value":"JP23790453"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790453/"}],"notation":[{"@language":"ja","@value":"ヒト化マウスモデルにおけるＨＩＶー１潜伏感染形成機序に関する研究"},{"@language":"en","@value":"Study for the mechanism of HIV-1 latent infection in a humanized mouse model"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257464077824","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"10J02353"},{"@type":"JGN","@value":"JP10J02353"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10J02353/"}],"notation":[{"@language":"ja","@value":"サルエイズモデルにおける長期SIV複製制御機序の解析"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335851790336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8+ T-cell frequencies in a macaque AIDS model"}]},{"@id":"https://cir.nii.ac.jp/crid/1050282810809690752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216192181120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of an AIDS vaccine using Sendai virus vectors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232001062656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of SIV Nef CD8+ T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232002412544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CD8+ T cell-based strong selective pressure on multiple simian immunodeficiency virus targets in macaques possessing a protective MHC class I haplotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234908964736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Augmentation of anti-simian immunodeficiency virus activity in CD8+ cells by neutralizing but not nonneutralizing antibodies in the acute phase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235985721216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biphasic CD8\n            <sup>+</sup>\n            T-Cell Defense in Simian Immunodeficiency Virus Control by Acute-Phase Passive Neutralizing Antibody Immunization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237662534144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143512103680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"AIDS vaccine models: Challenging challenge viruses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143871180160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Mamu-B</i>\n                    *\n                    <i>08</i>\n                    -Positive Macaques Control Simian Immunodeficiency Virus Replication"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145410940672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Importance of the nef gene for maintenance of high virus loads and for development of AIDS"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145494186368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preserved CD4+ Central Memory T Cells and Survival in Vaccinated SIV-Challenged Monkeys"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145712080640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168870217472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Late-phase dominance of a single epitope-specific CD8+ T-cell response in passive neutralizing antibody-infused simian immunodeficiency virus controllers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430669533312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694406572800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Limited Impact of Passive Non-Neutralizing Antibody Immunization in Acute SIV Infection on Viremia Control in Rhesus Macaques"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706976931328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710964905856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Control of Simian Immunodeficiency Virus Replication by Vaccine-Induced Gag- and Vif-Specific CD8\n            <sup>+</sup>\n            T Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617849536000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Therapeutic vaccine-mediated Gag-specific CD8+ T-cell induction under anti-retroviral therapy augments anti-virus efficacy of CD8+ cells in simian immunodeficiency virus-infected macaques"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620022003712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Favorable and Unfavorable HLA Class I Alleles and Haplotypes in Zambians Predominantly Infected with Clade C Human Immunodeficiency Virus Type 1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620751542272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621089156736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Rhesus Macaque Class I Duplicon Structures, Organization, and Evolution Within the Alpha Block of the Major Histocompatibility Complex"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181141940224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185940936704","@type":"Article","resourceType":"学術雑誌論文(journal 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