{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848661869080448.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1210/en.2017-00808"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/endo/article-pdf/159/1/163/23416778/en.2017-00808.pdf"}},{"identifier":{"@type":"PMID","@value":"29053844"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Evolutionally Conserved Function of Kisspeptin Neuronal System Is Nonreproductive Regulation as Revealed by Nonmammalian Study"}],"description":[{"notation":[{"@value":"The kisspeptin neuronal system, which consists of a neuropeptide kisspeptin and its receptor Gpr54, is considered in mammals a key factor of reproductive regulation, the so-called hypothalamic-pituitary-gonadal (HPG) axis. However, in nonmammalian vertebrates, especially in teleosts, existence of kisspeptin regulation on the HPG axis is still controversial. In this study, we applied multidisciplinary techniques to a teleost fish, medaka, and examined possible kisspeptin regulation on the HPG axis. First, we generated knockout medaka for kisspeptin-related genes and found that they show normal fertility, gonadal maturation, and expression of gonadotropins. Moreover, the firing activity of GnRH1 neurons recorded by the patch clamp technique was not altered by kisspeptin application. Furthermore, in goldfish, in vivo kisspeptin administration did not show any positive effect on HPG axis regulation. However, as kisspeptin genes are completely conserved among vertebrates except birds, we surmised that kisspeptin should have some important nonreproductive functions in vertebrates. Therefore, to discover novel functions of kisspeptin, we generated a gpr54-1:enhanced green fluorescent protein (EGFP) transgenic medaka, whose gpr54-1-expressing cells are specifically labeled by EGFP. Analysis of neuronal projection of gpr54-1:EGFP-expressing neurons showed that these neurons in the ventrolateral preoptic area project to the pituitary and are probably involved in endocrine regulation other than gonadotropin release. Furthermore, combination of deep sequencing, histological, and electrophysiological analyses revealed various novel neural systems that are under control of kisspeptin neurons-that is, those expressing neuropeptide Yb, cholecystokinin, isotocin, vasotocin, and neuropeptide B. Thus, our new strategy to genetically label receptor-expressing neurons gives insights into various kisspeptin-dependent neuronal systems that may be conserved in vertebrates."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380005518374429313","@type":"Researcher","foaf:name":[{"@value":"Mikoto Nakajo"}],"jpcoar:affiliationName":[{"@value":"Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, 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Kobayashi"}],"jpcoar:affiliationName":[{"@value":"Department of Life Science, International Christian University, Tokyo, 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Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=Recombinant%20Fusion%20Proteins","dc:title":"Recombinant Fusion Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Green%20Fluorescent%20Proteins","dc:title":"Green Fluorescent Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Oryzias","dc:title":"Oryzias"},{"@id":"https://cir.nii.ac.jp/all?q=Nerve%20Tissue%20Proteins","dc:title":"Nerve Tissue Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Animals,%20Genetically%20Modified","dc:title":"Animals, Genetically Modified"},{"@id":"https://cir.nii.ac.jp/all?q=Evolution,%20Molecular","dc:title":"Evolution, Molecular"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Knockout%20Techniques","dc:title":"Gene Knockout Techniques"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Isoforms","dc:title":"Protein Isoforms"},{"@id":"https://cir.nii.ac.jp/all?q=Gonads","dc:title":"Gonads"},{"@id":"https://cir.nii.ac.jp/all?q=Crosses,%20Genetic","dc:title":"Crosses, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Kisspeptins","dc:title":"Kisspeptins"},{"@id":"https://cir.nii.ac.jp/all?q=Preoptic%20Area","dc:title":"Preoptic Area"},{"@id":"https://cir.nii.ac.jp/all?q=Axons","dc:title":"Axons"},{"@id":"https://cir.nii.ac.jp/all?q=Pituitary%20Hormones","dc:title":"Pituitary Hormones"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Kisspeptin-1","dc:title":"Receptors, Kisspeptin-1"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782280695296","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26221104"},{"@type":"JGN","@value":"JP26221104"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26221104/"}],"notation":[{"@language":"ja","@value":"生殖と性行動の協調的制御に関わるペプチドニューロンの生物機能に関する統合的研究"},{"@language":"en","@value":"Coordinated regulation of reproduction and sexual behavior by peptidergic neurons"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564285786345728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"An Essential Role of the Arginine Vasotocin System in Mate-Guarding Behaviors in Triadic Relationships of Medaka Fish (Oryzias latipes)"},{"@value":"An essential role of the arginine vasotocin system in mate-guarding behaviors in triadic relationships of medaka fish (<italic>Oryzias 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