{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848662546019712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.pone.0186637"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.pone.0186637"}},{"identifier":{"@type":"PMID","@value":"29073149"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice"}],"description":[{"notation":[{"@value":"Type 1 diabetes mellitus is a progressive disease caused by the destruction of pancreatic β-cells, resulting in insulin dependency and hyperglycemia. While transplanted bone marrow-derived mesenchymal stem/stromal cells (BMMSCs) have been explored as an alternative therapeutic approach for diseases, the choice of delivery route may be a critical factor determining their sustainability. This study evaluated the effects of intrapancreatic and intravenous injection of human BMMSCs (hBMMSCs) in streptozotocin (STZ)-induced type 1 diabetic mouse model. C57/BL6 mice were intraperitoneally injected with 115 mg/kg STZ on day 0. hBMMSCs (1 × 106 cells) or vehicle were injected into the pancreas or jugular vein on day 7. Intrapancreatic, but not intravenous, hBMMSC injection significantly reduced blood glucose levels on day 28 compared with vehicle injection by the same route. This glucose-lowering effect was not induced by intrapancreatic injection of human fibroblasts as the xenograft control. Intrapancreatically injected fluorescence-labeled hBMMSCs were observed in the intra- and extra-lobular spaces of the pancreas, and intravenously injected cells were in the lung region, although the number of cells mostly decreased within 2 weeks of injection. For hBMMSCs injected twice into the pancreatic region on days 7 and 28, the injected mice had further reduced blood glucose to borderline diabetic levels on day 56. Animals injected with hBMMSCs twice exhibited increases in the plasma insulin level, number and size of islets, insulin-positive proportion of the total pancreas area, and intensity of insulin staining compared with vehicle-injected animals. We found a decrease of Iba1-positive cells in islets and an increase of CD206-positive cells in both the endocrine and exocrine pancreas. The hBMMSC injection also reduced the number of CD40-positive cells merged with glucagon immunoreactions in the islets. These results suggest that intrapancreatic injection may be a better delivery route of hBMMSCs for the treatment of type 1 diabetes mellitus."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848662546020360","@type":"Researcher","foaf:name":[{"@value":"Norimitsu Murai"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751137276544","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20349062"},{"@type":"NRID","@value":"1000020349062"},{"@type":"ORCID","@value":"0000-0003-3116-5265"},{"@type":"CINII_AUTHOR_ID","@value":"DB00435179"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DB00435179#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDB00435179"},{"@type":"NRID","@value":"9000257906528"},{"@type":"NRID","@value":"9000021082798"},{"@type":"NRID","@value":"9000410151156"},{"@type":"NRID","@value":"9000403733933"},{"@type":"NRID","@value":"9000403733938"},{"@type":"NRID","@value":"9000255736341"},{"@type":"NRID","@value":"9000413248099"},{"@type":"NRID","@value":"9000257905999"},{"@type":"NRID","@value":"9000257821437"},{"@type":"NRID","@value":"9000391552616"},{"@type":"NRID","@value":"9000272634744"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hironola"}],"foaf:name":[{"@value":"Hirokazu Ohtaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658586977283","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50649069"},{"@type":"NRID","@value":"1000050649069"},{"@type":"NRID","@value":"9000014578417"},{"@type":"NRID","@value":"9000408889818"},{"@type":"NRID","@value":"9000257821435"},{"@type":"NRID","@value":"9000404852891"},{"@type":"NRID","@value":"9000272634745"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/JunWatanabe"}],"foaf:name":[{"@value":"Jun Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848662546020224","@type":"Researcher","foaf:name":[{"@value":"Zhifang Xu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848662546020103","@type":"Researcher","foaf:name":[{"@value":"Shun Sasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848662546019715","@type":"Researcher","foaf:name":[{"@value":"Kazumichi Yagura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848662546020489","@type":"Researcher","foaf:name":[{"@value":"Seiji Shioda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848662546020229","@type":"Researcher","foaf:name":[{"@value":"Shoichiro Nagasaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751158176256","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10256505"},{"@type":"NRID","@value":"1000010256505"},{"@type":"NRID","@value":"9000347126898"},{"@type":"NRID","@value":"9000002043005"},{"@type":"NRID","@value":"9000107382788"},{"@type":"NRID","@value":"9000256091187"},{"@type":"NRID","@value":"9000340453286"},{"@type":"NRID","@value":"9000000300518"},{"@type":"NRID","@value":"9000022142828"},{"@type":"NRID","@value":"9000408793175"},{"@type":"NRID","@value":"9000255721938"},{"@type":"NRID","@value":"9000021875368"},{"@type":"NRID","@value":"9000256090184"},{"@type":"NRID","@value":"9000413248102"},{"@type":"NRID","@value":"9000263056116"},{"@type":"NRID","@value":"9000398151140"},{"@type":"NRID","@value":"9000241970221"},{"@type":"NRID","@value":"9000021236521"},{"@type":"NRID","@value":"9000254511267"},{"@type":"NRID","@value":"9000414756138"},{"@type":"NRID","@value":"9000021357515"},{"@type":"NRID","@value":"9000309571791"},{"@type":"NRID","@value":"9000397440251"},{"@type":"NRID","@value":"9000255722714"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hondakazuho"}],"foaf:name":[{"@value":"Kazuho Honda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848662546019970","@type":"Researcher","foaf:name":[{"@value":"Masahiko Izumizaki"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380848662546019851","@type":"Researcher","foaf:name":[{"@value":"Maria Cristina Vinci"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"19326203"}],"prism:publicationName":[{"@value":"PLOS ONE"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2017-10-26","prism:volume":"12","prism:number":"10","prism:startingPage":"e0186637"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.pone.0186637"}],"createdAt":"2017-10-26","modifiedAt":"2018-10-22","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Mesenchymal%20Stem%20Cell%20Transplantation","dc:title":"Mesenchymal Stem Cell Transplantation"},{"@id":"https://cir.nii.ac.jp/all?q=Streptozocin","dc:title":"Streptozocin"},{"@id":"https://cir.nii.ac.jp/all?q=Diabetes%20Mellitus,%20Experimental","dc:title":"Diabetes Mellitus, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Hyperglycemia","dc:title":"Hyperglycemia"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781901298304","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H05443"},{"@type":"JGN","@value":"JP16H05443"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05443/"}],"notation":[{"@language":"ja","@value":"虚血脳損傷保護に係わるヒト骨髄間葉系幹細胞由来因子の同定とグリア調節機構"},{"@language":"en","@value":"Determination of hMSCs-derived neuroprotective factors on brain ischemia and the glial modulating mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781917009536","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K11070"},{"@type":"JGN","@value":"JP16K11070"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K11070/"}],"notation":[{"@language":"ja","@value":"移植免疫反応と血管内皮の多様性：臓器間格差のメカニズムとグリコキャリックスの役割"},{"@language":"en","@value":"Role of endothelial glycocalyx in transplant immune responses; a mechanism of different susceptibility for rejection in various blood vessels"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781919193728","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K13054"},{"@type":"JGN","@value":"JP16K13054"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K13054/"}],"notation":[{"@language":"ja","@value":"一過性ストレスによる認知症の発症リスクと難溶性蛋白質の蓄積の相関性"},{"@language":"en","@value":"The contribution between cognitive impairment and accumulation of insoluble protein in brain after temporary stress."}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782306181376","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"26462769"},{"@type":"JGN","@value":"JP26462769"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462769/"}],"notation":[{"@language":"ja","@value":"重度熱中症における中枢神経障害の発症機構の解明と新規予防・治療法の開発"},{"@language":"en","@value":"brain damage after heat stroke in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256873215104","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16H02684"},{"@type":"JGN","@value":"JP16H02684"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H02684/"}],"notation":[{"@language":"ja","@value":"神経ペプチドPACAPによる脳・脊髄損傷の新規予防・治療法の開発と臨床応用研究"},{"@language":"en","@value":"Development and clinical application research of new preventive treatment method by neuropeptide PACAP for brain and spinal cord injury."}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256904203520","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K21372"},{"@type":"JGN","@value":"JP16K21372"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K21372/"}],"notation":[{"@language":"ja","@value":"頭部外傷における間葉系幹細胞と神経ペプチドの神経新生促進作用"},{"@language":"en","@value":"Neuro-regenerative effects of MSC and neuropeptide after traumatic brain injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256946266624","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K10943"},{"@type":"JGN","@value":"JP17K10943"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10943/"}],"notation":[{"@language":"ja","@value":"損傷脊髄における移植間葉系骨髄幹細胞のホーミングと運動療法との併用効果の検討"},{"@language":"en","@value":"Demonstration of transplanted Bone marrow derived mesenchymal stem/progenitor cells (MSCs) homing and co-effect of kinetic therapy on the spinal cord injury"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215868514048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237559892608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Local Delivery of Mesenchymal Stem Cells with Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold Suppress Arthritis in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143661081856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143845089536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multipotent mesenchymal stromal cells and the innate immune system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144458959872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction therapy in pancreas transplantation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144840604416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Five-year follow-up of patients with type 1 diabetes transplanted with allogeneic islets: the UIC experience"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144899301632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD40"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145498055296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145725956992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146250002048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical Roles for Macrophages in Islet Angiogenesis and Maintenance During Pancreatic Degeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146503944064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Dynamic in vivo Distribution of Bone Marrow-Derived Mesenchymal Stem Cells after Infusion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693977146112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707275140352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The anti-inflammatory property of human bone marrow-derived mesenchymal stem/stromal cells is preserved in late-passage cultures"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712501437952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Therapeutic Effects of Human Mesenchymal Stem Cells in Wistar-Kyoto Rats with Anti-Glomerular Basement Membrane Glomerulonephritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619808054400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bone marrow- and subcutaneous adipose tissue-derived mesenchymal stem cells: Differences and similarities"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620068864128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TSG-6 Produced by hMSCs Delays the Onset of Autoimmune Diabetes by Suppressing Th1 Development and Enhancing Tolerogenicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620298379264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620714059648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multiple Intravenous Transplantations of Mesenchymal Stem Cells Effectively Restore Long-Term Blood Glucose Homeostasis by Hepatic Engraftment and β-Cell Differentiation in Streptozocin-Induced Diabetic Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621163767424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glucagon Deficiency Reduces Hepatic Glucose Production and Improves Glucose Tolerance In Adult Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621435939584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094327109888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094496008320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proinflammatory Responses Induced by CD40 in Retinal Endothelial and Muller Cells are Inhibited by Blocking CD40-Traf2,3 or CD40-Traf6 Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094779792128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti-CD154 (CD40L) prevents recurrence of diabetes in islet isografts in the DR-BB rat."}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094910467200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dual regeneration of muscle and nerve by intravenous administration of human amniotic fluid–derived mesenchymal stem cells regulated by stromal cell–derived factor-1α in a sciatic nerve injury model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640753260544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569024185216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation of BM mesenchymal stem cells by plastic adhesion or negative selection: phenotype, proliferation kinetics and differentiation potential"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569566824960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570164784128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Contribution of CD40/CD40L Axis in Inflammatory Bowel Disease: An Update"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570610689536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal Stem Cells Prevent Hypertrophic Scar Formation via Inflammatory Regulation when Undergoing Apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571444169728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Coculture of human liver macrophages and cholangiocytes leads to CD40-dependent apoptosis and cytokine secretion"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043406559488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044611206400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046166439808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intraperitoneal injection (IP), Intravenous injection (IV) or anal injection (AI)? Best way for mesenchymal stem cells transplantation for colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046336219904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD40–CD40 Ligand Interaction Activates Proinflammatory Pathways in Pancreatic Islets"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519768310016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas–Kidney Transplants"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520092981120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted Intra-arterial Transplantation of Stem Cells to the Injured CNS is more Effective than Intravenous Administration: Engraftment is Dependent on Cell Type and Adhesion Molecule Expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520108545152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"New treatment for cystic tumors of the pancreas: EUS-guided ethanol lavage with paclitaxel injection"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468563350272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470296446208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470579809920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD40–CD40 ligand interactions in oxidative stress, inflammation and vascular disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470992369664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943401979136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"β-Cell Regeneration Mediated by Human Bone Marrow Mesenchymal Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945947027200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420047486976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stem cell‐based treatments for Type 1 diabetes mellitus: bone marrow, embryonic, hepatic, pancreatic and induced pluripotent stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421288438784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Why should mesenchymal stem cells (MSCs) cure autoimmune diseases?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894606487552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multilineage Potential of Adult Human Mesenchymal Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894770087936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895597373568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Is the intravascular administration of mesenchymal stem cells safe?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896193387520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal stem cells: clinical applications and biological characterization"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896314513664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369307131008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369586575872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/\n                    <i>scid</i>\n                    mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369634417920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Topographical cues regulate the crosstalk between MSCs and macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843355862144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-α in patients with recent-onset type 1 diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843454693248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Monocyte and macrophage heterogeneity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844189637376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Niche-Dependent Regulations of Metabolic Balance in High-Fat Diet–Induced Diabetic Mice by Mesenchymal Stromal Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844341658624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protein and energy metabolism in type 1 diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845203717632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846362179072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Potential causes of weight gain in type 1 diabetes mellitus"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318573763968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recovery of Endocrine Function After Islet and Pancreas Transplantation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319802025216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stem Cell Niche, the Microenvironment and Immunological Crosstalk"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320445458304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Periostin Induces Pancreatic Regeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793287653632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793938753664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"TRAF-1, -2, -3, -5, and -6 Are Induced in Atherosclerotic Plaques and Differentially Mediate Proinflammatory Functions of CD40L in Endothelial Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794964700288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795485787264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular mechanism and function of CD40/CD40L engagement in the immune system"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795816556672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CD40 activation in human pancreatic islets and ductal cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269219885312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Feasibility of EUS-guided injection of irinotecan-loaded microspheres into the swine pancreas"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270231628032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A functional CD40 receptor is expressed in pancreatic beta cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270928508544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preserved β-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1370848662546020482","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1371/journal.pone.0186637"},{"@type":"KAKEN","@value":"PRODUCT-21753020"},{"@type":"KAKEN","@value":"PRODUCT-21444182"},{"@type":"KAKEN","@value":"PRODUCT-21505471"},{"@type":"KAKEN","@value":"PRODUCT-21879325"},{"@type":"KAKEN","@value":"PRODUCT-21679839"},{"@type":"KAKEN","@value":"PRODUCT-21537906"},{"@type":"KAKEN","@value":"PRODUCT-21495115"},{"@type":"OPENAIRE","@value":"doi_dedup___::97b292f4b9f819492a28fbb6c5dea0d2"}]}