{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848664360484352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fcell.2014.00075"}},{"identifier":{"@type":"PMID","@value":"25642423"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP"}],"description":[{"notation":[{"@value":"Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp (-/-)) mice. So far, six types of Prnp (-/-) mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obtained from comparative studies of structural and functional analyses of these PrP family proteins do not fully reveal PrP functions. Recently, varieties of Prnp (-/-) cell lines established from Prnp (-/-) mice have contributed to the analysis of PrP functions. In this mini-review, we focus on Prnp (-/-) cell lines and summarize currently available Prnp (-/-) cell lines and their characterizations. In addition, we introduce the recent advances in the methodology of cell line generation with knockout or knockdown of the PrP gene. We also discuss how these cell lines have provided valuable insights into PrP functions and show future perspectives."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751136251776","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10397672"},{"@type":"NRID","@value":"1000010397672"},{"@type":"NRID","@value":"9000312735524"},{"@type":"NRID","@value":"9000412226747"},{"@type":"NRID","@value":"9000409373794"},{"@type":"NRID","@value":"9000022969483"},{"@type":"NRID","@value":"9000020918495"},{"@type":"NRID","@value":"9000018655319"},{"@type":"NRID","@value":"9000398144420"},{"@type":"NRID","@value":"9000241610034"},{"@type":"NRID","@value":"9000351064890"},{"@type":"NRID","@value":"9000255327767"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/sakudo"}],"foaf:name":[{"@value":"Akikazu Sakudo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848664360483981","@type":"Researcher","foaf:name":[{"@value":"Takashi Onodera"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"2296634X"}],"prism:publicationName":[{"@value":"Frontiers in Cell and Developmental Biology"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2015-01-15","prism:volume":"2"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","createdAt":"2015-01-15","modifiedAt":"2023-08-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Shadoo","dc:title":"Shadoo"},{"@id":"https://cir.nii.ac.jp/all?q=QH301-705.5","dc:title":"QH301-705.5"},{"@id":"https://cir.nii.ac.jp/all?q=Doppel","dc:title":"Doppel"},{"@id":"https://cir.nii.ac.jp/all?q=Prnp%E2%88%92/%E2%88%92%20cell%20line","dc:title":"Prnp−/− cell line"},{"@id":"https://cir.nii.ac.jp/all?q=Prnp-/-%20cell%20line","dc:title":"Prnp-/- cell line"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20and%20Developmental%20Biology","dc:title":"Cell and Developmental Biology"},{"@id":"https://cir.nii.ac.jp/all?q=prion%20protein","dc:title":"prion protein"},{"@id":"https://cir.nii.ac.jp/all?q=Biology%20(General)","dc:title":"Biology (General)"},{"@id":"https://cir.nii.ac.jp/all?q=knockout%20mouse","dc:title":"knockout mouse"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782257380864","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25450447"},{"@type":"JGN","@value":"JP25450447"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25450447/"}],"notation":[{"@language":"ja","@value":"ミクログリアにおけるプリオン蛋白質の機能とプリオン感染病態に関する研究"},{"@language":"en","@value":"Analysis of prion protein in microglia/macrophages in the pathophysiology of prion disease"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144156912768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proteomics Approach to Identify the Interacting Partners of Cellular Prion Protein and Characterization of Rab7a 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undergoes aggregation and fibrillization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571436388864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571525146368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuritogenesis: the prion protein controls β1 integrin signaling activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043417173632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prion protein lacks robust cytoprotective activity in cultured cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043994084480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Axonal prion protein is required for peripheral myelin 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hamster, and bovine Prnp"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520555034880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Normal host prion protein necessary for scrapie-induced neurotoxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521017605376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Circumventing Tolerance to the Prion Protein (PrP): Vaccination with PrP-Displaying Retrovirus Particles Induces Humoral Immune Responses against the Native Form of Cellular PrP"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521071899520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521221383680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mice devoid of PrP are resistant to scrapie"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521502834432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prion protein PrPc interacts with molecular chaperones of the Hsp60 family"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993915193600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RETRACTED: The Complex PrP<sup>c</sup>-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994476786432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The immortalized cell lines with differentiation potentials: Their establishment and possible application"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994622734080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of antibodies against human prion proteins (PrP) by DNA-mediated immunization of mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994859377536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995006244736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The prion protein as a receptor for amyloid-β"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995091620736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Normal host prion protein (PrP\n            <sup>C</sup>\n            ) is required for scrapie spread within the central nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995535617664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Establishment and characterization of multipotent neural cell lines using retrovirus vector‐mediated oncogene transfer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996428749312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regional heterogeneity of cellular prion protein isoforms in the mouse brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468411357184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Copper and prion disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468546404224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Functional Implication of Cellular Prion Protein in Antigen-Driven Interactions between T Cells and Dendritic Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468620702336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prion protein expression alters APP cleavage without interaction with BACE-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468697512064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Generation of Antibodies Against Prion Protein by Scrapie-Infected Cell Immunization of PrP\n                    <sup>0/0</sup>\n                    Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469099619456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A cellular form of prion protein (PrPC) exists in many non-neuronal tissues of sheep"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469120642560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469179396224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular prion protein status in sheep: tissue-specific biochemical 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