{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360848664436753280.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/molecules17066705"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/1420-3049/17/6/6705/pdf"}},{"identifier":{"@type":"PMID","@value":"22728364"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Calculation of the Stabilization Energies of Oxidatively Damaged Guanine Base Pairs with Guanine"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>DNA is constantly exposed to endogenous and exogenous oxidative stresses. Damaged DNA can cause mutations, which may increase the risk of developing cancer and other diseases. G:C-C:G transversions are caused by various oxidative stresses. 2,2,4-Triamino-5(2H)-oxazolone (Oz), guanidinohydantoin (Gh)/iminoallantoin (Ia) and spiro-imino-dihydantoin (Sp) are known products of oxidative guanine damage. These damaged bases can base pair with guanine and cause G:C-C:G transversions. In this study, the stabilization energies of these bases paired with guanine were calculated in vacuo and in water. The calculated stabilization energies of the Ia:G base pairs were similar to that of the native C:G base pair, and both bases pairs have three hydrogen bonds. By contrast, the calculated stabilization energies of Gh:G, which form two hydrogen bonds, were lower than the Ia:G base pairs, suggesting that the stabilization energy depends on the number of hydrogen bonds. In addition, the Sp:G base pairs were less stable than the Ia:G base pairs. Furthermore, calculations showed that the Oz:G base pairs were less stable than the Ia:G, Gh:G and Sp:G base pairs, even though experimental results showed that incorporation of guanine opposite Oz is more efficient than that opposite Gh/Ia and Sp.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380848664436753154","@type":"Researcher","foaf:name":[{"@value":"Masayo Suzuki"}],"jpcoar:affiliationName":[{"@value":"Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Shido, Sanuki, Kagawa 769-2193, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326234863232","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70360534"},{"@type":"NRID","@value":"1000070360534"},{"@type":"NRID","@value":"9000006640082"},{"@type":"NRID","@value":"9000364822371"},{"@type":"NRID","@value":"9000257967128"},{"@type":"NRID","@value":"9000318156986"},{"@type":"NRID","@value":"9000398143772"},{"@type":"NRID","@value":"9000272989340"},{"@type":"NRID","@value":"9000397801721"},{"@type":"NRID","@value":"9000006373636"},{"@type":"NRID","@value":"9000364822409"},{"@type":"NRID","@value":"9000356511503"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0054010"}],"foaf:name":[{"@value":"Katsuhito Kino"}],"jpcoar:affiliationName":[{"@value":"Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Shido, Sanuki, Kagawa 769-2193, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030581148808531584","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000014611760"},{"@type":"NRID","@value":"9000278508144"},{"@type":"NRID","@value":"9000272989339"},{"@type":"NRID","@value":"9000309166943"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/mmorikawa"}],"foaf:name":[{"@value":"Masayuki Morikawa"}],"jpcoar:affiliationName":[{"@value":"Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Shido, Sanuki, Kagawa 769-2193, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204631225728","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000278508142"},{"@type":"NRID","@value":"9000398143771"},{"@type":"NRID","@value":"9000272989337"},{"@type":"NRID","@value":"9000397801720"},{"@type":"NRID","@value":"9000255679376"},{"@type":"NRID","@value":"9000006775761"},{"@type":"NRID","@value":"9000345215561"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0110640"}],"foaf:name":[{"@value":"Takanobu Kobayashi"}],"jpcoar:affiliationName":[{"@value":"Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Shido, Sanuki, Kagawa 769-2193, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380848664436753285","@type":"Researcher","foaf:name":[{"@value":"Rie Komori"}],"jpcoar:affiliationName":[{"@value":"Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Shido, Sanuki, Kagawa 769-2193, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658414575872","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40183967"},{"@type":"NRID","@value":"1000040183967"},{"@type":"NRID","@value":"9000005457706"},{"@type":"NRID","@value":"9000006640083"},{"@type":"NRID","@value":"9000252860092"},{"@type":"NRID","@value":"9000401859219"},{"@type":"NRID","@value":"9000392744436"},{"@type":"NRID","@value":"9000257967129"},{"@type":"NRID","@value":"9000398143773"},{"@type":"NRID","@value":"9000272989342"},{"@type":"NRID","@value":"9000397801722"},{"@type":"NRID","@value":"9000000185003"},{"@type":"NRID","@value":"9000003351482"},{"@type":"NRID","@value":"9000253182186"},{"@type":"NRID","@value":"9000255679378"},{"@type":"NRID","@value":"9000000028173"},{"@type":"NRID","@value":"9000005594741"},{"@type":"NRID","@value":"9000006373640"},{"@type":"NRID","@value":"9000004745343"},{"@type":"NRID","@value":"9000309166948"},{"@type":"NRID","@value":"9000254564232"},{"@type":"NRID","@value":"9000256517223"},{"@type":"NRID","@value":"9000317127695"},{"@type":"NRID","@value":"9000317127785"},{"@type":"NRID","@value":"9000242883331"},{"@type":"NRID","@value":"9000392742972"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/55hirm_resm_rht"}],"foaf:name":[{"@value":"Hiroshi Miyazawa"}],"jpcoar:affiliationName":[{"@value":"Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1, Shido, Sanuki, Kagawa 769-2193, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14203049"}],"prism:publicationName":[{"@value":"Molecules"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2012-06-01","prism:volume":"17","prism:number":"6","prism:startingPage":"6705","prism:endingPage":"6715"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/3.0/"],"url":[{"@id":"https://www.mdpi.com/1420-3049/17/6/6705/pdf"}],"createdAt":"2012-06-01","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=oxidative%20guanine%20damage","dc:title":"oxidative guanine damage"},{"@id":"https://cir.nii.ac.jp/all?q=hydrogen%20bond","dc:title":"hydrogen bond"},{"@id":"https://cir.nii.ac.jp/all?q=Guanine","dc:title":"Guanine"},{"@id":"https://cir.nii.ac.jp/all?q=Organic%20chemistry","dc:title":"Organic chemistry"},{"@id":"https://cir.nii.ac.jp/all?q=stabilization%20energy","dc:title":"stabilization energy"},{"@id":"https://cir.nii.ac.jp/all?q=Hydrogen%20Bonding","dc:title":"Hydrogen Bonding"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Genomic%20Instability","dc:title":"Genomic Instability"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidative%20Stress","dc:title":"Oxidative Stress"},{"@id":"https://cir.nii.ac.jp/all?q=QD241-441","dc:title":"QD241-441"},{"@id":"https://cir.nii.ac.jp/all?q=base%20pair","dc:title":"base pair"},{"@id":"https://cir.nii.ac.jp/all?q=Base%20Pairing","dc:title":"Base Pairing"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidation-Reduction","dc:title":"Oxidation-Reduction"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Damage","dc:title":"DNA Damage"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257133394176","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23510069"},{"@type":"JGN","@value":"JP23510069"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23510069/"}],"notation":[{"@language":"ja","@value":"オキサゾロン連続クラスター損傷に関する突然変異および修復反応の解析"},{"@language":"en","@value":"Study on the oxazolone-oxazolone cluster damage"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360290617484595968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Products of Oxidative Guanine Damage Form Base Pairs with Guanine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620117131648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Eukaryotic DNA Polymerases α, β and ε Incorporate Guanine Opposite 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