{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360849942707910656.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s2468-2667(19)30155-0"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2468266719301550?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S2468266719301550?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"31588030"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Age at natural menopause and risk of incident cardiovascular disease: a pooled analysis of individual patient data"}],"description":[{"notation":[{"@value":"Early menopause is linked to an increased risk of cardiovascular disease mortality; however, the association between early menopause and incidence and timing of cardiovascular disease is unclear. We aimed to assess the associations between age at natural menopause and incidence and timing of cardiovascular disease.We harmonised and pooled individual-level data from 15 observational studies done across five countries and regions (Australia, Scandinavia, the USA, Japan, and the UK) between 1946 and 2013. Women who had reported their menopause status, age at natural menopause (if postmenopausal), and cardiovascular disease status (including coronary heart disease and stroke) were included. We excluded women who had hysterectomy or oophorectomy and women who did not report their age at menopause. The primary endpoint of this study was the occurrence of first non-fatal cardiovascular disease, defined as a composite outcome of incident coronary heart disease (including heart attack and angina) or stroke (including ischaemic stroke or haemorrhagic stroke). We used Cox proportional hazards models to estimate multivariate hazard ratios (HRs) and 95% CIs for the associations between age at menopause and incident cardiovascular disease event. We also adjusted the model to account for smoking status, menopausal hormone therapy status, body-mass index, and education levels. Age at natural menopause was categorised as premenopausal or perimenopausal, younger than 40 years (premature menopause), 40-44 years (early menopause), 45-49 years (relatively early), 50-51 years (reference category), 52-54 years (relatively late), and 55 years or older (late menopause).Overall, 301 438 women were included in our analysis. Of these 301 438 women, 12 962 (4·3%) had a first non-fatal cardiovascular disease event after menopause, of whom 9369 (3·1%) had coronary heart disease and 4338 (1·4%) had strokes. Compared with women who had menopause at age 50-51 years, the risk of cardiovascular disease was higher in women who had premature menopause (age40 years; HR 1·55, 95% CI 1·38-1·73; p0·0001), early menopause (age 40-44 years; 1·30, 1·22-1·39; p0·0001), and relatively early menopause (age 45-49 years; 1·12, 1·07-1·18; p0·0001), with a significantly reduced risk of cardiovascular disease following menopause after age 51 years (p0·0001 for trend). The associations persisted in never smokers, and were strongest before age 60 years for women with premature menopause (HR 1·88, 1·62-2·20; p0·0001) and early menopause (1·40, 1·27-1·54; p0·0001), but were attenuated at age 60-69 years, with no significant association observed at age 70 years and older.Compared with women who had menopause at age 50-51 years, women with premature and early menopause had a substantially increased risk of a non-fatal cardiovascular disease event before the age of 60 years, but not after age 70 years. Women with earlier menopause need close monitoring in clinical practice, and age at menopause might also be considered as an important factor in risk stratification of cardiovascular disease for women.Australian National Health and Medical Research Council."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380849942707910670","@type":"Researcher","foaf:name":[{"@value":"Dongshan Zhu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910666","@type":"Researcher","foaf:name":[{"@value":"Hsin-Fang Chung"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910796","@type":"Researcher","foaf:name":[{"@value":"Annette J Dobson"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910934","@type":"Researcher","foaf:name":[{"@value":"Nirmala Pandeya"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911171","@type":"Researcher","foaf:name":[{"@value":"Graham G Giles"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911048","@type":"Researcher","foaf:name":[{"@value":"Fiona Bruinsma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910790","@type":"Researcher","foaf:name":[{"@value":"Eric J Brunner"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911177","@type":"Researcher","foaf:name":[{"@value":"Diana Kuh"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911052","@type":"Researcher","foaf:name":[{"@value":"Rebecca Hardy"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911044","@type":"Researcher","foaf:name":[{"@value":"Nancy E Avis"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910663","@type":"Researcher","foaf:name":[{"@value":"Ellen B Gold"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911176","@type":"Researcher","foaf:name":[{"@value":"Carol A Derby"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910797","@type":"Researcher","foaf:name":[{"@value":"Karen A Matthews"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911041","@type":"Researcher","foaf:name":[{"@value":"Janet E Cade"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910667","@type":"Researcher","foaf:name":[{"@value":"Darren C Greenwood"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910657","@type":"Researcher","foaf:name":[{"@value":"Panayotes Demakakos"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910936","@type":"Researcher","foaf:name":[{"@value":"Daniel E Brown"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910659","@type":"Researcher","foaf:name":[{"@value":"Lynnette L Sievert"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911054","@type":"Researcher","foaf:name":[{"@value":"Debra Anderson"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326213612928","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80282408"},{"@type":"NRID","@value":"1000080282408"},{"@type":"ORCID","@value":"0000-0003-4648-3936"},{"@type":"NRID","@value":"9000010431654"},{"@type":"NRID","@value":"9000392763753"},{"@type":"NRID","@value":"9000404787480"},{"@type":"NRID","@value":"9000410037489"},{"@type":"NRID","@value":"9000283358949"},{"@type":"NRID","@value":"9000017327482"},{"@type":"NRID","@value":"9000364572357"},{"@type":"NRID","@value":"9000411622430"},{"@type":"NRID","@value":"9000005287477"},{"@type":"NRID","@value":"9000379072854"},{"@type":"NRID","@value":"9000402945517"},{"@type":"NRID","@value":"9000399513156"},{"@type":"NRID","@value":"9000010431666"},{"@type":"NRID","@value":"9000238244728"},{"@type":"NRID","@value":"9000257974571"},{"@type":"NRID","@value":"9000415423373"},{"@type":"NRID","@value":"9000411039610"},{"@type":"NRID","@value":"9000283344666"},{"@type":"NRID","@value":"9000000577816"},{"@type":"NRID","@value":"9000263053990"},{"@type":"NRID","@value":"9000365108008"},{"@type":"NRID","@value":"9000311067923"},{"@type":"NRID","@value":"9000410037390"},{"@type":"NRID","@value":"9000258586054"},{"@type":"NRID","@value":"9000411635401"},{"@type":"NRID","@value":"9000021463811"},{"@type":"NRID","@value":"9000402395292"},{"@type":"NRID","@value":"9000009690474"},{"@type":"NRID","@value":"9000412402452"},{"@type":"NRID","@value":"9000409579736"},{"@type":"NRID","@value":"9000286622311"},{"@type":"NRID","@value":"9000411622440"},{"@type":"NRID","@value":"9000403312256"},{"@type":"NRID","@value":"9000018244096"},{"@type":"NRID","@value":"9000411522659"},{"@type":"NRID","@value":"9000409289093"},{"@type":"NRID","@value":"9000241960814"},{"@type":"NRID","@value":"9000365620165"},{"@type":"NRID","@value":"9000248214068"},{"@type":"NRID","@value":"9000005280865"},{"@type":"NRID","@value":"9000020572737"},{"@type":"NRID","@value":"9000367427163"},{"@type":"NRID","@value":"9000257974563"},{"@type":"NRID","@value":"9000007565177"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0051606"}],"foaf:name":[{"@value":"Kunihiko Hayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910915","@type":"Researcher","foaf:name":[{"@value":"Jung Su Lee"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910935","@type":"Researcher","foaf:name":[{"@value":"Hideki Mizunuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910668","@type":"Researcher","foaf:name":[{"@value":"Therese Tillin"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911178","@type":"Researcher","foaf:name":[{"@value":"Mette Kildevæld Simonsen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910938","@type":"Researcher","foaf:name":[{"@value":"Hans-Olov Adami"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707910917","@type":"Researcher","foaf:name":[{"@value":"Elisabete Weiderpass"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849942707911175","@type":"Researcher","foaf:name":[{"@value":"Gita D Mishra"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"24682667"}],"prism:publicationName":[{"@value":"The Lancet Public Health"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2019-11","prism:volume":"4","prism:number":"11","prism:startingPage":"e553","prism:endingPage":"e564"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by-nc-nd/3.0/igo/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S2468266719301550?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S2468266719301550?httpAccept=text/plain"}],"createdAt":"2019-10-03","modifiedAt":"2025-11-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Design","dc:title":"Design"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=610","dc:title":"610"},{"@id":"https://cir.nii.ac.jp/all?q=Coronary%20Disease","dc:title":"Coronary Disease"},{"@id":"https://cir.nii.ac.jp/all?q=2739%20Public%20Health","dc:title":"2739 Public Health"},{"@id":"https://cir.nii.ac.jp/all?q=Risk%20Assessment","dc:title":"Risk Assessment"},{"@id":"https://cir.nii.ac.jp/all?q=Postmenopausal%20Women","dc:title":"Postmenopausal Women"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Body%20Mass%20Index","dc:title":"Body Mass Index"},{"@id":"https://cir.nii.ac.jp/all?q=Life","dc:title":"Life"},{"@id":"https://cir.nii.ac.jp/all?q=Risk%20Factors","dc:title":"Risk Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Proportional%20Hazards%20Models","dc:title":"Proportional Hazards Models"},{"@id":"https://cir.nii.ac.jp/all?q=Cohort%20Profile","dc:title":"Cohort Profile"},{"@id":"https://cir.nii.ac.jp/all?q=Incidence","dc:title":"Incidence"},{"@id":"https://cir.nii.ac.jp/all?q=Ischemic-Heart-Disease","dc:title":"Ischemic-Heart-Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Environmental%20and%20Occupational%20Health","dc:title":"Environmental and Occupational Health"},{"@id":"https://cir.nii.ac.jp/all?q=Estrogen%20Replacement%20Therapy","dc:title":"Estrogen Replacement Therapy"},{"@id":"https://cir.nii.ac.jp/all?q=Smoking","dc:title":"Smoking"},{"@id":"https://cir.nii.ac.jp/all?q=Age%20Factors","dc:title":"Age Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Estrogen","dc:title":"Estrogen"},{"@id":"https://cir.nii.ac.jp/all?q=Stroke","dc:title":"Stroke"},{"@id":"https://cir.nii.ac.jp/all?q=Observational%20Studies%20as%20Topic","dc:title":"Observational Studies as Topic"},{"@id":"https://cir.nii.ac.jp/all?q=Health","dc:title":"Health"},{"@id":"https://cir.nii.ac.jp/all?q=Cardiovascular%20Diseases","dc:title":"Cardiovascular Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Hormone-Therapy","dc:title":"Hormone-Therapy"},{"@id":"https://cir.nii.ac.jp/all?q=Interlace","dc:title":"Interlace"},{"@id":"https://cir.nii.ac.jp/all?q=Educational%20Status","dc:title":"Educational Status"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Public%20aspects%20of%20medicine","dc:title":"Public aspects of medicine"},{"@id":"https://cir.nii.ac.jp/all?q=RA1-1270","dc:title":"RA1-1270"},{"@id":"https://cir.nii.ac.jp/all?q=Menopause","dc:title":"Menopause"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781994290304","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H04069"},{"@type":"JGN","@value":"JP18H04069"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H04069/"}],"notation":[{"@language":"ja","@value":"本邦女性のヘルスケア利用におけるリアル・ワールド・エビデンスの構築"},{"@language":"en","@value":"Real World Evidence for Health Care in Japanese Women"}]},{"@id":"https://cir.nii.ac.jp/crid/1040285300660847744","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19KK0235"},{"@type":"JGN","@value":"JP19KK0235"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19KK0235/"}],"notation":[{"@language":"ja","@value":"女性の健康における世界のコホート統合研究：日本女性と諸外国女性の比較"},{"@language":"en","@value":"A cross cohort study on women health: comparisons between Japanese and women in other countries"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002216069845248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"InterLACE: A new International Collaboration for a Life Course Approach to Women's Reproductive Health and Chronic Disease Events"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142932354304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144301790976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort Profile: The Swedish Women’s Lifestyle and Health cohort"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021391866019456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ethnic Differences in the Association Between Age at Natural Menopause and Risk of Type 2 Diabetes Among Postmenopausal Women: A Pooled Analysis of Individual Data From 13 Cohort Studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706326155776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Premenopausal cardiovascular disease and age at natural menopause: a pooled analysis of over 170,000 women"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619368752256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort profile: 1958 British birth cohort (National Child Development Study)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619698965888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early menopause predicts future coronary heart disease and stroke"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620061021568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Validity and reproducibility of self-reported age at menopause in women participating in the DOM-project"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621025169792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort Profile: The Australian Longitudinal Study on Women's Health"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621046771328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sex Hormone Levels and Risk of Cardiovascular Events in Postmenopausal Women"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621397408512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Quality of life in climacteric women"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306904411577856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reproductive factors predict risks of cardiovascular disease and premature death in postmenopausal women with type 2 diabetes: The Fukuoka Diabetes Registry"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166023331456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The InterLACE study: Design, data harmonization and characteristics across 20 studies on women’s health"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187422453248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Relationships between intensity, duration, cumulative dose, and timing of smoking with age at menopause: A pooled analysis of individual data from 17 observational studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094049314304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Natural Menopause and Risk of Stroke in Elderly Women"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094094517120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Premature menopause in a multi-ethnic population study of the menopause transition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095285123712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Global Burden of Ischemic Heart Disease in 1990 and 2010"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095355620736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort Profile: The English Longitudinal Study of Ageing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569643378048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Duration of Reproductive Life Span, Age at Menarche, and Age at Menopause Are Associated With Risk of Cardiovascular Disease in Women"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869856056551168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association between endometriosis and type and age of menopause: a pooled analysis of 279 948 women from five cohort studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044549169152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Southall And Brent REvisited: Cohort profile of SABRE, a UK population-based comparison of cardiovascular disease and diabetes in people of European, Indian Asian and African Caribbean origins"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044929861760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Myth and paradox of coronary risk and the menopause"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045016145792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Age at menopause as a risk factor for cardiovascular mortality"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045300159360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518945076992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Age at Natural Menopause and Risk of Ischemic Stroke"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520093265280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Premature menopause is associated with increased risk of cerebral infarction in Japanese women"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520584867712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Protective Effects of Estrogen on the Cardiovascular System"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994205815040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Factors Associated with Age at Natural Menopause in a Multiethnic Sample of Midlife Women"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994740046464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468391448320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort Profile: The Danish nurse cohort"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469296836736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stroke risk in women: the role of menopause and hormone therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469362176128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sex Hormone–Binding Globulin and the Free Androgen Index Are Related to Cardiovascular Risk Factors in Multiethnic Premenopausal and Perimenopausal Women Enrolled in the Study of Women Across the Nation (SWAN)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469946571648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470603759104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A longitudinal study of the impact of chronic psychological stress on health-related quality of life and clinical biomarkers: protocol for the Australian Healthy Aging of Women Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471345017856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of early age at natural menopause on coronary heart disease and stroke in Chinese women"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471440550400","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Age-Related Differences in Health Complaints: The Hilo Women's Health Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943385444608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Factors Related to Age at Natural Menopause: Longitudinal Analyses From SWAN"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944007026944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort Profile: The 1946 National Birth Cohort (MRC National Survey of Health and Development)"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946377543936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Are Changes in Cardiovascular Disease Risk Factors in Midlife Women Due to Chronological Aging or to the Menopausal Transition?"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418284727424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Socioeconomic position, lifestyle factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418941926016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort Profile: The Whitehall II study"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419044144384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420449103744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort Profile: The UK Women’s Cohort Study (UKWCS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420913796096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The North American Menopause Society Recommendations for Clinical Care of Midlife Women"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421275141376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Body mass index and age at natural menopause: an international pooled analysis of 11 prospective studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893560001792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Postmenopausal Hormone Therapy and Stroke"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893744888448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Estrogen and the cardiovascular system"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894101920128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Timing of the Age at Which Natural Menopause Occurs"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895536614144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The association between early menopause and risk of ischaemic heart disease: Influence of Hormone Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895986427904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368581209088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Age at Natural Menopause and Risk of Cardiovascular Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368882384256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hysterectomy and risk of cardiovascular disease: a population-based cohort study"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370409949568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hip fracture in postmenopausal women after cessation of hormone therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370879527552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cohort Profile: The Melbourne Collaborative Cohort Study (Health 2020)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318785523200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Estrogen Receptor Subtypes Mediate Distinct Microvascular Dilation and Reduction in [Ca2+]i in Mesenteric Microvessels of Female Rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795253236352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Association of menopausal characteristics and risk of coronary heart disease: a pan-European case–cohort analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795863023616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Menopause"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268915457664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Estimated 10-year cardiovascular mortality seriously underestimates overall cardiovascular risk"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849942707910666","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hormone therapy for preventing cardiovascular disease in post-menopausal women"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849942707910924","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of premature ovarian failure"}]},{"@id":"https://cir.nii.ac.jp/crid/1370849942707911170","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SWAN: a multicenter, multiethnic, community-based cohort study of women and the menopausal transition"}]},{"@id":"https://cir.nii.ac.jp/crid/1390010799166309120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Administration of Isoflavone Attenuates Ovariectomy-induced Degeneration of Aortic Wall"}]},{"@id":"https://cir.nii.ac.jp/crid/1390019590262145664","@type":"Article","resourceType":"エディトリアル(editorial)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recognizing Female Reproductive Factors in Interpreting Changes in Disease Burden Among Populations"}]},{"@id":"https://cir.nii.ac.jp/crid/1390022565147799808","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association between urinary polycyclic aromatic hydrocarbon metabolites and premature menopause: a nationally representative cross-sectional study in the United States"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679255722880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Design of the Japan Nurses' Health Study: A Prospective Occupational Cohort Study of Women's Health in Japan"},{"@value":"Design of the Japan Nurses' Health Study—a prospective occupational cohort study of women's health in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390578437525547392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Female Reproductive Events and Subclinical Atherosclerosis of the Brain and Carotid Arteriopathy: the Ohasama Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390852879453357056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ovariectomy Causes Degeneration of Perivascular Adipose Tissue"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/s2468-2667(19)30155-0"},{"@type":"KAKEN","@value":"PRODUCT-22894651"},{"@type":"KAKEN","@value":"PRODUCT-22821105"},{"@type":"OPENAIRE","@value":"doi_dedup___::4aed9ff54275f5a18816466e17137c51"},{"@type":"CROSSREF","@value":"10.2337/dc23-1209_references_DOI_at0aBYEfbzupVV4W6BTfHauLlY"},{"@type":"CROSSREF","@value":"10.5551/jat.63592_references_DOI_at0aBYEfbzupVV4W6BTfHauLlY"},{"@type":"CROSSREF","@value":"10.5650/jos.ess22043_references_DOI_at0aBYEfbzupVV4W6BTfHauLlY"},{"@type":"CROSSREF","@value":"10.1016/j.diabres.2024.111907_references_DOI_at0aBYEfbzupVV4W6BTfHauLlY"},{"@type":"CROSSREF","@value":"10.5650/jos.ess21179_references_DOI_at0aBYEfbzupVV4W6BTfHauLlY"},{"@type":"CROSSREF","@value":"10.2188/jea.je20240123_references_DOI_at0aBYEfbzupVV4W6BTfHauLlY"},{"@type":"CROSSREF","@value":"10.1265/ehpm.25-00031_references_DOI_at0aBYEfbzupVV4W6BTfHauLlY"},{"@type":"CROSSREF","@value":"10.1093/humrep/deaf068_references_DOI_at0aBYEfbzupVV4W6BTfHauLlY"}]}