{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360849944832451840.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1101/2020.03.05.20028407"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1101/2020.03.05.20028407"}}],"resourceType":"preprint","dc:title":[{"@value":"High-contrast in-vivo imaging of tau pathologies in Alzheimer’s and non-Alzheimer’s disease tauopathies"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>SUMMRAY</jats:title>\n                <jats:p>\n                  A panel of radiochemicals has enabled\n                  <jats:italic>in-vivo</jats:italic>\n                  positron emission tomography (PET) of tau pathologies in Alzheimer’s disease (AD), while sensitive detection of frontotemporal lobar degeneration (FTLD) tau inclusions has been unsuccessful. Here, we generated an imaging probe, PM-PBB3, for capturing diverse tau deposits.\n                  <jats:italic>In-vitro</jats:italic>\n                  assays demonstrated the reactivity of this compound with tau pathologies in AD and FTLD. We could also utilize PM-PBB3 for optical/PET imaging of a living murine tauopathy model. A subsequent clinical PET study revealed increased binding of\n                  <jats:sup>18</jats:sup>\n                  F-PM-PBB3 in diseased patients, reflecting cortical-dominant AD and subcortical-dominant PSP tau topologies. Notably, the\n                  <jats:italic>in-vivo</jats:italic>\n                  reactivity of\n                  <jats:sup>18</jats:sup>\n                  F-PM-PBB3 with FTLD tau inclusion was strongly supported by neuropathological examinations of autopsied and biopsied brains derived from Pick’s disease, PSP and corticobasal degeneration patients who underwent PET scans. Finally, visual inspection of\n                  <jats:sup>18</jats:sup>\n                  F-PM-PBB3-PET images was indicated to facilitate individually based identification of diverse clinical phenotypes of FTLD on the neuropathological basis.\n                </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380849944832451969","@type":"Researcher","foaf:name":[{"@value":"Kenji Tagai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452099","@type":"Researcher","foaf:name":[{"@value":"Maiko Ono"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801196544384","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30760368"},{"@type":"NRID","@value":"1000030760368"},{"@type":"ORCID","@value":"0000-0001-9507-1845"},{"@type":"NRID","@value":"9000263059200"},{"@type":"NRID","@value":"9000023351033"},{"@type":"NRID","@value":"9000345376217"},{"@type":"NRID","@value":"9000411517113"},{"@type":"NRID","@value":"9000024098962"},{"@type":"NRID","@value":"9000297476906"},{"@type":"NRID","@value":"9000390878419"},{"@type":"NRID","@value":"9000271445340"},{"@type":"NRID","@value":"9000310328184"},{"@type":"NRID","@value":"9000319555453"},{"@type":"NRID","@value":"9000398992949"},{"@type":"NRID","@value":"9000323844194"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/m_kubota"}],"foaf:name":[{"@value":"Manabu Kubota"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452105","@type":"Researcher","foaf:name":[{"@value":"Soichiro Kitamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451974","@type":"Researcher","foaf:name":[{"@value":"Keisuke Takahata"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451971","@type":"Researcher","foaf:name":[{"@value":"Chie Seki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451842","@type":"Researcher","foaf:name":[{"@value":"Yuhei Takado"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451844","@type":"Researcher","foaf:name":[{"@value":"Hitoshi Shinotoh"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452103","@type":"Researcher","foaf:name":[{"@value":"Yasunori Sano"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452224","@type":"Researcher","foaf:name":[{"@value":"Kiwamu Matsuoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451848","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Takuwa"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801195126016","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20455348"},{"@type":"NRID","@value":"1000020455348"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/Masafumi_Shimojo"}],"foaf:name":[{"@value":"Masafumi Shimojo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451843","@type":"Researcher","foaf:name":[{"@value":"Manami Takahashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451976","@type":"Researcher","foaf:name":[{"@value":"Kazunori Kawamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452101","@type":"Researcher","foaf:name":[{"@value":"Tatsuya Kikuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452097","@type":"Researcher","foaf:name":[{"@value":"Maki Okada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452098","@type":"Researcher","foaf:name":[{"@value":"Haruhiko Akiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451840","@type":"Researcher","foaf:name":[{"@value":"Hisaomi Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451847","@type":"Researcher","foaf:name":[{"@value":"Mitsumoto Onaya"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451975","@type":"Researcher","foaf:name":[{"@value":"Takahiro Takeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452104","@type":"Researcher","foaf:name":[{"@value":"Kimihito Arai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452102","@type":"Researcher","foaf:name":[{"@value":"Nobutaka Arai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452096","@type":"Researcher","foaf:name":[{"@value":"Nobuyuki Araki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451977","@type":"Researcher","foaf:name":[{"@value":"Yuko Saito"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451841","@type":"Researcher","foaf:name":[{"@value":"Yasuyuki Kimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451973","@type":"Researcher","foaf:name":[{"@value":"Masanori Ichise"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451845","@type":"Researcher","foaf:name":[{"@value":"Yutaka Tomita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451712","@type":"Researcher","foaf:name":[{"@value":"Ming-Rong Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451968","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Suhara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451970","@type":"Researcher","foaf:name":[{"@value":"Masahiro Shigeta"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451713","@type":"Researcher","foaf:name":[{"@value":"Naruhiko Sahara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832452225","@type":"Researcher","foaf:name":[{"@value":"Makoto Higuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849944832451846","@type":"Researcher","foaf:name":[{"@value":"Hitoshi Shimada"}]}],"publication":{"dc:publisher":[{"@value":"openRxiv"}],"prism:publicationDate":"2020-03-11"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1101/2020.03.05.20028407"}],"createdAt":"2020-03-11","modifiedAt":"2026-01-15","project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782023168128","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K17101"},{"@type":"JGN","@value":"JP19K17101"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17101/"}],"notation":[{"@language":"ja","@value":"PDE10Aイメージングを用いた多次元画像研究による統合失調症圏の層別化"},{"@language":"en","@value":"Classification of schizophrenia-related disorders by multimodal neuroimaging assessments of PDE10A"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002220464475904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PET Quantification of Tau Pathology in Human Brain with 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study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694049303424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vivo visualization of tau deposits in corticobasal syndrome by\n            <sup>18</sup>\n            F-THK5351 PET"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695441193984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<sup>18</sup>F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619350747008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical diagnosis of Alzheimer's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619644059776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"101 Labeled Brain Images and a Consistent Human Cortical Labeling 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Tomographic Imaging of Glial Responses to Amyloid-β and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189096257280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Radiosynthesis, Photoisomerization, Biodistribution, and Metabolite Analysis of <sup>11</sup>C-PBB3 as a Clinically Useful PET Probe for Imaging of Tau Pathology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360570166683560320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095479782528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preliminary NINDS neuropathologic criteria for Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096308694272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096369218176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preclinical Characterization of<sup>18</sup>F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643936484864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664380165888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tau Filaments and the Development of Positron Emission Tomography Tracers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360849944410587136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569720815744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570213267328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Frontotemporal Lobar Degeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571185810560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the 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Brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519630941568","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tau Positron-Emission Tomography in Former National Football League Players"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521001286272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-Term <i>in Vivo</i> Investigation of Mouse Cerebral Microcirculation by Fluorescence Confocal Microscopy in the Area of Focal Ischemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521407614080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular and regional vulnerability in frontotemporal tauopathies"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993706304640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Preclinical Evaluation of <sup>18</sup>F-RO6958948, <sup>11</sup>C-RO6931643, and <sup>11</sup>C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994372960256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994829166208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An autoradiographic evaluation of AV-1451 Tau PET in dementia"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995989975040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469167183744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tau and neurodegenerative disease: the story so far"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469172904704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tau-targeting therapies for Alzheimer disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944221320192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<sup>18</sup>F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945511042688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neurodegenerative Diseases: Expanding the Prion Concept"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945687489664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Different Positron Emission Tomography Tau Tracers Bind to Multiple Binding Sites on the Tau Fibril: Insight from Computational Modeling"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418978000384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A clinical rating scale for progressive supranuclear palsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419125602816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420192480256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<sup>18</sup>F‐flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420710050176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"[F‐18]AV‐1451 positron emission tomography retention in choroid plexus: More than “off‐target” binding"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893778256128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107368364207360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843384325760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cryo-EM structures of tau filaments from Alzheimer’s disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843983225216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vivo quantification of neurofibrillary tangles with 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