Potential Role of Nonneutralizing IgA Antibodies in Cross-Protective Immunity against Influenza A Viruses of Multiple Hemagglutinin Subtypes

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  • Kosuke Okuya
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Reiko Yoshida
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Rashid Manzoor
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Shinji Saito
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
  • Tadaki Suzuki
    Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
  • Michihito Sasaki
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Takeshi Saito
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Yurie Kida
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Akina Mori-Kajihara
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Tatsunari Kondoh
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Masahiro Sato
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Masahiro Kajihara
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Hiroko Miyamoto
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Osamu Ichii
    Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan
  • Hideaki Higashi
    Division of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Ayato Takada
    Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  • Colin R. Parrish
    editor

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説明

<jats:p> Mucosal immunity represented by pSIgA plays important roles in protection from IAV infection. Furthermore, IAV HA-specific pSIgA antibodies are thought to contribute to cross-protective immunity against multiple IAV subtypes. However, the mechanisms by which pSIgA exerts such versatile antiviral activity are not fully understood. In this study, we generated broadly cross-reactive recombinant IgG and pSIgA having the same antigen-recognition site and compared their antiviral activities <jats:italic>in vitro</jats:italic> . These recombinant antibodies did not show “classical” neutralizing activity, whereas pSIgA, but not IgG, significantly inhibited the production of progeny virus particles from infected cells. Plaque formation was also significantly reduced by pSIgA, but not IgG. These effects were seen in infection with IAVs of several different HA subtypes. Based on our findings, we propose an antibody-mediated host defense mechanism by which mucosal immunity may contribute to broad cross-protection from IAVs of multiple HA subtypes, including viruses with pandemic potential. </jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 94 (12), e00408-, 2020-06

    American Society for Microbiology

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