{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360849946804672000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1186/s12885-019-5730-1"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1186/s12885-019-5730-1.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1186/s12885-019-5730-1/fulltext.html"}},{"identifier":{"@type":"PMID","@value":"31142289"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma"}],"description":[{"notation":[{"@value":"Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy caused by long-term human T-cell leukemia virus type I (HTLV-1) infection. Survivin-responsive, conditionally replicating adenoviruses regulated by multiple tumor-specific factors (Surv.m-CRAs), in which the expression of the adenoviral early region 1A gene is regulated by the survivin (BIRC5) promoter, can be used to treat several cancers. As survivin is overexpressed in ATL, we examined the effects of Surv.m-CRAs on ATL-selective replication and survival.We tested two ATL cell lines and four HTLV-1-infected T-cell lines. The cells were subjected to infection with either E1-deleted, replication-defective adenoviruses or Surv.m-CRAs at various multiplicities of infection.Strong activation of survivin promoter was observed in all six cell lines. Moreover, the expression of the coxsackie and adenovirus receptor (CAR), which is important for adenoviral infection, was high in the cell lines. In contrast, we observed the absence of survivin promoter activity and a low expression of CAR in activated peripheral blood lymphocytes (PBLs) from healthy subjects. Surv.m-CRAs actively replicated and induced cytocidal effects in five out of six cell lines; conversely, we observed minimal viral replication and no marked cytotoxicity in normal activated PBLs.This is the first report demonstrating that Surv.m-CRAs constitute attractive potential anti-ATL agents."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420845751137475712","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20437974"},{"@type":"NRID","@value":"1000020437974"}],"foaf:name":[{"@value":"Shinsuke Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849946804672259","@type":"Researcher","foaf:name":[{"@value":"Hiroki Kofune"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849946804672003","@type":"Researcher","foaf:name":[{"@value":"Kimiharu Uozumi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849946804671874","@type":"Researcher","foaf:name":[{"@value":"Makoto Yoshimitsu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849946804672005","@type":"Researcher","foaf:name":[{"@value":"Naomichi Arima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849946804672140","@type":"Researcher","foaf:name":[{"@value":"Kenji Ishitsuka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380849946804672000","@type":"Researcher","foaf:name":[{"@value":"Shin-ichi Ueno"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326214714496","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90258418"},{"@type":"NRID","@value":"1000090258418"},{"@type":"NRID","@value":"9000004683578"},{"@type":"NRID","@value":"9000318158440"},{"@type":"NRID","@value":"9000256793687"},{"@type":"NRID","@value":"9000021444970"},{"@type":"NRID","@value":"9000001913871"},{"@type":"NRID","@value":"9000356631059"},{"@type":"NRID","@value":"9000021500532"},{"@type":"NRID","@value":"9000010936305"},{"@type":"NRID","@value":"9000006449734"},{"@type":"NRID","@value":"9000255959346"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0200306"}],"foaf:name":[{"@value":"Ken-ichiro Kosai"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14712407"}],"prism:publicationName":[{"@value":"BMC Cancer"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2019-05-29","prism:volume":"19","prism:number":"1"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1186/s12885-019-5730-1.pdf"},{"@id":"http://link.springer.com/article/10.1186/s12885-019-5730-1/fulltext.html"}],"createdAt":"2019-05-29","modifiedAt":"2020-05-27","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Survivin","dc:title":"Survivin"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms.%20Tumors.%20Oncology.%20Including%20cancer%20and%20carcinogens","dc:title":"Neoplasms. Tumors. Oncology. Including cancer and carcinogens"},{"@id":"https://cir.nii.ac.jp/all?q=Virus%20Replication","dc:title":"Virus Replication"},{"@id":"https://cir.nii.ac.jp/all?q=Adenoviridae","dc:title":"Adenoviridae"},{"@id":"https://cir.nii.ac.jp/all?q=Conditionally%20replicating%20adenoviruses","dc:title":"Conditionally replicating adenoviruses"},{"@id":"https://cir.nii.ac.jp/all?q=ATL","dc:title":"ATL"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Leukemia-Lymphoma,%20Adult%20T-Cell","dc:title":"Leukemia-Lymphoma, Adult T-Cell"},{"@id":"https://cir.nii.ac.jp/all?q=Adenovirus%20E1A%20Proteins","dc:title":"Adenovirus E1A Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Promoter%20Regions,%20Genetic","dc:title":"Promoter Regions, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=RC254-282","dc:title":"RC254-282"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782019500672","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K08870"},{"@type":"JGN","@value":"JP19K08870"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08870/"}],"notation":[{"@language":"ja","@value":"生体内ゲノム編集を利用したHTLV-1を標的にする新規抗ウイルス療法"},{"@language":"en","@value":"Novel antiviral therapy targeting HTLV-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256934424704","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17H04315"},{"@type":"JGN","@value":"JP17H04315"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04315/"}],"notation":[{"@language":"ja","@value":"骨軟部肉腫への腫瘍溶解・免疫誘導・癌幹細胞制圧の革新的な遺伝子ウイルス治療の開発"},{"@language":"en","@value":"Development of Innovative Gene-Virus Therapy for Tumor Lysis, Immunity Induction, and Cancer Stem Cell Suppression in Bone and Soft Tissue Sarcoma."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004236881929600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multicenter Phase II Study of Lenalidomide in Relapsed or Recurrent Adult T-Cell Leukemia/Lymphoma: ATLL-002"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146204712064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693931217024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective 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Untreated Melanoma without\n                    <i>BRAF</i>\n                    Mutation"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369923704832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843598911104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843728218496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adenovirus Vector-Based Purging of Multiple Myeloma Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844395967232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An efficient construction of conditionally replicating adenoviruses that target tumor cells with multiple 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