{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360850316100703616.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1021/acs.biomac.8b00588"}},{"identifier":{"@type":"URI","@value":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.8b00588"}},{"identifier":{"@type":"PMID","@value":"29985587"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel"}],"description":[{"notation":[{"@value":"We have developed a new hydrogel hemostat composed of hyaluronan (HA) conjugated with inorganic polyphosphate (PolyP). A hemostatic hydrogel, HAX-PolyP, was formed rapidly by mixing aldehyde-modified HA and hydrazide-modified HA conjugated with PolyP (HA-PolyP). Although the gelation rate decreased with increasing PolyP content, the gelation time was below 5 min. In addition, the hydrogel swelling volume decreased with increasing PolyP content, but the degradation rate did not depend on PolyP content and the hydrogel underwent complete degradation through hydrolysis over 3 weeks in phosphate buffered saline. HAX-PolyP showed similar biocompatibility with the HA hydrogel without PolyP conjugation in vitro and in vivo. Intraperitoneal administration of HAX-PolyP did not induce any adhesion in the peritoneum and clot formation in the lungs. Finally, HA-PolyP accelerated the coagulation rate of human plasma ex vivo, and HAX-PolyP showed as strong a hemostatic effect as fibrin glue in a mouse liver bleeding model in vivo."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380850316100703618","@type":"Researcher","foaf:name":[{"@value":"Megumu Sakoda"}],"jpcoar:affiliationName":[{"@value":"Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380850316100703620","@type":"Researcher","foaf:name":[{"@value":"Makoto Kaneko"}]},{"@id":"https://cir.nii.ac.jp/crid/1380850316100703617","@type":"Researcher","foaf:name":[{"@value":"Seiichi Ohta"}]},{"@id":"https://cir.nii.ac.jp/crid/1380850316100703622","@type":"Researcher","foaf:name":[{"@value":"Pan Qi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380850316100703616","@type":"Researcher","foaf:name":[{"@value":"Shigetoshi Ichimura"}],"jpcoar:affiliationName":[{"@value":"Department of Applied Bioscience, Kanagawa Institute of Technology, 1030 Shimo-ogino, Atsugi, Kanagawa 243-0292, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380850316100703621","@type":"Researcher","foaf:name":[{"@value":"Yutaka 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Ito"}],"jpcoar:affiliationName":[{"@value":"Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15257797"},{"@type":"EISSN","@value":"15264602"}],"prism:publicationName":[{"@value":"Biomacromolecules"}],"dc:publisher":[{"@value":"American Chemical Society (ACS)"}],"prism:publicationDate":"2018-07-09","prism:volume":"19","prism:number":"8","prism:startingPage":"3280","prism:endingPage":"3290"},"reviewed":"false","url":[{"@id":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.8b00588"}],"createdAt":"2018-07-09","modifiedAt":"2023-04-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20ICR","dc:title":"Mice, Inbred ICR"},{"@id":"https://cir.nii.ac.jp/all?q=Hydrogels","dc:title":"Hydrogels"},{"@id":"https://cir.nii.ac.jp/all?q=3T3%20Cells","dc:title":"3T3 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