{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360853567516302592.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/cbdv.202000037"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbdv.202000037"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202000037"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cbdv.202000037"}},{"identifier":{"@type":"PMID","@value":"32163220"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Antimelanogenic Activity of Ocotillol‐Type Saponins from <i>Panax vietnamensis</i>"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The ocotillol (OCT)‐type saponins have been known as a tetracyclic triterpenoid, possessing five‐ or six‐membered epoxy ring in the side chain. Interestingly, this type saponin was mostly found in <jats:italic>Panax vietnamensis</jats:italic> <jats:sc>Ha</jats:sc> et <jats:sc>Grushv</jats:sc>., Araliaceae (VG), hence making VG unique from the other <jats:italic>Panax</jats:italic> spp. Five OCT‐type saponins, majonoside R2, vina‐ginsenoside R2, majonoside R1, pseudoginsenoside RT4, vina‐ginsenoside R11, together with three protopanaxadiol (PPD)‐type saponins and four protopanaxatriol (PPT)‐type saponins from VG were evaluated for their antimelanogenic activity. All of isolates were found to be active. More importantly, the five OCT‐type saponins inhibited melanin production in B16‐F10 mouse melanoma cells, without showing any cytotoxicity. Besides ginsenoside Rd and ginsenoside Rg3 in PPD and notoginsenoside R1 in PPT‐type saponins, majonoside R2 was the most potent melanogenesis inhibitory activity in OCT‐type saponins. In this article, we highlighted antimelanogenic activity of OCT‐type saponins and potential structure–activity relationship (SAR) of ginsenosides. Our results suggested that OCT‐type saponins could be used as a depigmentation agent.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380853567516302597","@type":"Researcher","foaf:name":[{"@value":"Hien Minh Nguyen"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmacy Ton Duc Thang University  Ho Chi Minh City 700000 Vietnam"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302727","@type":"Researcher","foaf:name":[{"@value":"Huy Truong Nguyen"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmacy Ton Duc Thang University  Ho Chi Minh City 700000 Vietnam"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302723","@type":"Researcher","foaf:name":[{"@value":"Nwet Win"}],"jpcoar:affiliationName":[{"@value":"Institute of Natural Medicine University of Toyama  2630-Sugitani Toyama 930-0194 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302724","@type":"Researcher","foaf:name":[{"@value":"Chin Piow Wong"}],"jpcoar:affiliationName":[{"@value":"Institute of Natural Medicine University of Toyama  2630-Sugitani Toyama 930-0194 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302593","@type":"Researcher","foaf:name":[{"@value":"Kim Long Vu Huynh"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmacy Ton Duc Thang University  Ho Chi Minh City 700000 Vietnam"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302594","@type":"Researcher","foaf:name":[{"@value":"Nhat Nam Hoang"}],"jpcoar:affiliationName":[{"@value":"Institute of Natural Medicine University of Toyama  2630-Sugitani Toyama 930-0194 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302722","@type":"Researcher","foaf:name":[{"@value":"Kiep Minh Do"}],"jpcoar:affiliationName":[{"@value":"Institute of Natural Medicine University of Toyama  2630-Sugitani Toyama 930-0194 Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302729","@type":"Researcher","foaf:name":[{"@value":"Hoai Thi Nguyen"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University 49000  Vietnam"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302728","@type":"Researcher","foaf:name":[{"@value":"Duc Viet Ho"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University 49000  Vietnam"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302720","@type":"Researcher","foaf:name":[{"@value":"Minh Duc Nguyen"}],"jpcoar:affiliationName":[{"@value":"Faculty of Pharmacy Ton Duc Thang University  Ho Chi Minh City 700000 Vietnam"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567516302725","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Morita"}],"jpcoar:affiliationName":[{"@value":"Institute of Natural Medicine University of Toyama  2630-Sugitani Toyama 930-0194 Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"16121872"},{"@type":"EISSN","@value":"16121880"}],"prism:publicationName":[{"@value":"Chemistry & Biodiversity"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2020-04-15","prism:volume":"17","prism:number":"5"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbdv.202000037"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202000037"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cbdv.202000037"}],"createdAt":"2020-03-12","modifiedAt":"2023-09-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Melanins","dc:title":"Melanins"},{"@id":"https://cir.nii.ac.jp/all?q=Plants,%20Medicinal","dc:title":"Plants, Medicinal"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Ginsenosides","dc:title":"Ginsenosides"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Survival","dc:title":"Cell 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Proliferation"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782015223936","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H04649"},{"@type":"JGN","@value":"JP19H04649"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H04649/"}],"notation":[{"@language":"ja","@value":"ポリケタイド閉環酵素とバイヤービリガー酵素の機能改変と新規化合物の創出"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360855569030215424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of Thyroid Tumours in(C57BL/6N×C3H/N)F1 Mice by Oral Administration of Kojic Acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569562837248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Processed Vietnamese ginseng: Preliminary results in chemistry and biological activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571219626624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ginseng 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