{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360853567579763584.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/ijms21217817"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/1422-0067/21/21/7817/pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Truncating Variants Contribute to Hearing Loss and Severe Retinopathy in USH2A-Associated Retinitis Pigmentosa in Japanese Patients"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>USH2A is a common causal gene of retinitis pigmentosa (RP), a progressive blinding disease due to retinal degeneration. Genetic alterations in USH2A can lead to two types of RP, non-syndromic and syndromic RP, which is called Usher syndrome, with impairments of vision and hearing. The complexity of the genotype–phenotype correlation in USH2A-associated RP (USH2A-RP) has been reported. Genetic and clinical characterization of USH2A-RP has not been performed in Japanese patients. In this study, genetic analyses were performed using targeted panel sequencing in 525 Japanese RP patients. Pathogenic variants of USH2A were identified in 36 of 525 (6.9%) patients and genetic features of USH2A-RP were characterized. Among 36 patients with USH2A-RP, 11 patients had syndromic RP with congenital hearing problems. Amino acid changes due to USH2A alterations were similarly located throughout entire regions of the USH2A protein structure in non-syndromic and syndromic RP cases. Notably, truncating variants were detected in all syndromic patients with a more severe retinal phenotype as compared to non-syndromic RP cases. Taken together, truncating variants could contribute to more serious functional and tissue damages in Japanese patients, suggesting important roles for truncating mutations in the pathogenesis of syndromic USH2A-RP.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380853567579763587","@type":"Researcher","foaf:name":[{"@value":"Akira Inaba"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan"},{"@value":"Laboratory for Retinal Regeneration, RIKEN, Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan"},{"@value":"Department of Medical Ethics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567579763586","@type":"Researcher","foaf:name":[{"@value":"Akiko Maeda"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan"},{"@value":"Laboratory for Retinal Regeneration, RIKEN, Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567579763458","@type":"Researcher","foaf:name":[{"@value":"Akiko Yoshida"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan"},{"@value":"Laboratory for Retinal Regeneration, RIKEN, Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567579763584","@type":"Researcher","foaf:name":[{"@value":"Kanako Kawai"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan"},{"@value":"Laboratory for Retinal Regeneration, RIKEN, Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567579763459","@type":"Researcher","foaf:name":[{"@value":"Yasuhiko Hirami"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan"},{"@value":"Laboratory for Retinal Regeneration, RIKEN, Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567579763456","@type":"Researcher","foaf:name":[{"@value":"Yasuo Kurimoto"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan"},{"@value":"Laboratory for Retinal Regeneration, RIKEN, Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326232479232","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50252432"},{"@type":"NRID","@value":"1000050252432"},{"@type":"ORCID","@value":"0000-0001-6036-6491"},{"@type":"CINII_AUTHOR_ID","@value":"DA12219945"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA12219945#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA12219945"},{"@type":"NRID","@value":"9000006204254"},{"@type":"NRID","@value":"9000415350516"},{"@type":"NRID","@value":"9000404135872"},{"@type":"NRID","@value":"9000238381840"},{"@type":"NRID","@value":"9000402608889"},{"@type":"NRID","@value":"9000409982108"},{"@type":"NRID","@value":"9000403260068"},{"@type":"NRID","@value":"9000414086997"},{"@type":"NRID","@value":"9000408461787"},{"@type":"NRID","@value":"9000409999953"},{"@type":"NRID","@value":"9000398956979"},{"@type":"NRID","@value":"9000410919405"},{"@type":"NRID","@value":"9000252824261"},{"@type":"NRID","@value":"9000410919401"},{"@type":"NRID","@value":"9000409838141"},{"@type":"NRID","@value":"9000018850864"},{"@type":"NRID","@value":"9000241815202"},{"@type":"NRID","@value":"9000259862139"},{"@type":"NRID","@value":"9000404343617"},{"@type":"NRID","@value":"9000242744015"},{"@type":"NRID","@value":"9000404481298"},{"@type":"NRID","@value":"9000410199367"},{"@type":"NRID","@value":"9000016912727"},{"@type":"NRID","@value":"9000257754546"},{"@type":"NRID","@value":"9000413580606"},{"@type":"NRID","@value":"9000411243458"},{"@type":"NRID","@value":"9000409170298"},{"@type":"NRID","@value":"9000356649892"},{"@type":"NRID","@value":"9000362802685"},{"@type":"NRID","@value":"9000263057729"},{"@type":"NRID","@value":"9000406379930"},{"@type":"NRID","@value":"9000409886346"},{"@type":"NRID","@value":"9000409475342"},{"@type":"NRID","@value":"9000323844163"},{"@type":"NRID","@value":"9000414847702"},{"@type":"NRID","@value":"9000413868134"},{"@type":"NRID","@value":"9000264550341"},{"@type":"NRID","@value":"9000314795640"},{"@type":"NRID","@value":"9000398631199"},{"@type":"NRID","@value":"9000411540469"},{"@type":"NRID","@value":"9000326644928"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0042641"}],"foaf:name":[{"@value":"Shinji Kosugi"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Ethics, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326213583360","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80252443"},{"@type":"NRID","@value":"1000080252443"},{"@type":"NDL_AUTHOR_ID","@value":"001133822"},{"@type":"NRID","@value":"9000009730501"},{"@type":"NRID","@value":"9000001994137"},{"@type":"NRID","@value":"9000398801369"},{"@type":"NRID","@value":"9000406388101"},{"@type":"NRID","@value":"9000387431749"},{"@type":"NRID","@value":"9000022776148"},{"@type":"NRID","@value":"9000000886016"},{"@type":"NRID","@value":"9000007594164"},{"@type":"NRID","@value":"9000002185334"},{"@type":"NRID","@value":"9000412274753"},{"@type":"NRID","@value":"9000411812678"},{"@type":"NRID","@value":"9000258060839"},{"@type":"NRID","@value":"9000257983681"},{"@type":"NRID","@value":"9000241635002"},{"@type":"NRID","@value":"9000018784937"},{"@type":"NRID","@value":"9000017047103"},{"@type":"NRID","@value":"9000414499892"},{"@type":"NRID","@value":"9000321630134"},{"@type":"NRID","@value":"9000283404960"},{"@type":"NRID","@value":"9000020303367"},{"@type":"NRID","@value":"9000404821280"},{"@type":"NRID","@value":"9000351091544"},{"@type":"NRID","@value":"9000018490106"},{"@type":"NRID","@value":"9000241635032"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/retina"}],"foaf:name":[{"@value":"Masayo Takahashi"}],"jpcoar:affiliationName":[{"@value":"Department of Ophthalmology, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan"},{"@value":"Laboratory for Retinal Regeneration, RIKEN, Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14220067"}],"prism:publicationName":[{"@value":"International Journal of Molecular Sciences"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2020-10-22","prism:volume":"21","prism:number":"21","prism:startingPage":"7817"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/1422-0067/21/21/7817/pdf"}],"createdAt":"2020-10-22","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%3Ci%3EUSH2A%3C/i%3E","dc:title":"<i>USH2A</i>"},{"@id":"https://cir.nii.ac.jp/all?q=clinical%20sequence","dc:title":"clinical sequence"},{"@id":"https://cir.nii.ac.jp/all?q=retinitis%20pigmentosa","dc:title":"retinitis pigmentosa"},{"@id":"https://cir.nii.ac.jp/all?q=inherited%20retinal%20degeneration","dc:title":"inherited retinal degeneration"},{"@id":"https://cir.nii.ac.jp/all?q=Usher%20syndrome","dc:title":"Usher syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782000130048","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K07411"},{"@type":"JGN","@value":"JP18K07411"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07411/"}],"notation":[{"@language":"ja","@value":"ゲノム医療実装のためのヒト遺伝子関連検査の妥当性・有用性・倫理社会的問題の検討"},{"@language":"en","@value":"Examination of validity, usefulness, ethical and social issues of human gene tests for implementation of genomic medicinel"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335832548992","@type":"Article","resourceType":"学術雑誌論文(journal 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article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The first USH2A mutation analysis of Japanese autosomal recessive retinitis pigmentosa patients: a totally different mutation profile with the lack of frequent mutations found in Caucasian patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709139093504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Visual Outcomes in Japanese Patients with Retinitis Pigmentosa and Usher Syndrome Caused by\n            <i>USH2A</i>\n            Mutations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620658830848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mutation of a Gene Encoding a Protein with Extracellular Matrix Motifs in Usher Syndrome Type IIa"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168756984576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comprehensive Molecular Diagnosis of a Large Cohort of Japanese Retinitis Pigmentosa and Usher Syndrome Patients by Next-Generation Sequencing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092889643520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095819990784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Severe or Profound Sensorineural Hearing Loss Caused by Novel <i>USH2A</i> Variants in Korea: Potential Genotype-Phenotype Correlation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641760132992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658340098304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Novel USH2A mutations in Japanese Usher syndrome type 2 patients: marked differences in the mutation spectrum between the Japanese and other populations"}]},{"@id":"https://cir.nii.ac.jp/crid/1360849943277578240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Japanese family with cone-rod dystrophy of delayed onset caused by a compound heterozygous combination of novel CDHR1 frameshift and known missense variants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567865291776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"HGVS Recommendations for the Description of Sequence Variants: 2016 Update"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861289347353600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genotype and phenotype characteristics of RHO-associated retinitis pigmentosa in the Japanese population"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044981525120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Usherin defects lead to early-onset retinal dysfunction in zebrafish"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045874189440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetics of Usher Syndrome: New Insights From a Meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518375662592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ASSOCIATION BETWEEN GENOTYPE AND DISEASE PROGRESSION IN ITALIAN STARGARDT PATIENTS"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518512986112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Visual Acuities “Hand Motion” and “Counting Fingers” Can Be Quantified with the Freiburg Visual Acuity Test"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520356895872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Disease Course in Patients with Autosomal Recessive Retinitis Pigmentosa due to the<i>USH2A</i>Gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520566298112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular basis of human Usher syndrome: Deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994773583744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469603023488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of 51 Novel Exons of the Usher Syndrome Type 2A (USH2A) Gene That Encode Multiple Conserved Functional Domains and That Are Mutated in Patients with Usher Syndrome Type II"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470453652480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Investigating the disease association of <i>USH2A</i> p.C759F variant by leveraging large retinitis pigmentosa cohort data"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943518654080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>USH2A</i> variants in Chinese patients with Usher syndrome type II and\n                  non-syndromic retinitis pigmentosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944030846080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Knockout of ush2a gene in zebrafish causes hearing impairment and late onset rod-cone dystrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944125484544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Visual acuity impairment in patients with retinitis pigmentosa at age 45 years or older"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945721618944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Re‐evaluation casts doubt on the pathogenicity of homozygous <i>USH2A</i> p.C759F"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418777635328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Missense Mutation in the USH2A Gene: Association with Recessive Retinitis Pigmentosa without Hearing Loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893902049664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893921560960","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comprehensive sequence analysis of nine Usher syndrome genes in the UK National Collaborative Usher Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894867227904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ciliopathy: Usher Syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895617845760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Allelic hierarchy of\n                    <i>CDH23</i>\n                    mutations causing non-syndromic deafness DFNB12 or Usher syndrome USH1D in compound heterozygotes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370051195520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CDH23 Mutation and Phenotype Heterogeneity: A Profile of 107 Diverse Families with Usher Syndrome and Nonsyndromic Deafness"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370225947008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Photoreceptor Cilia and Retinal Ciliopathies"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107371318975360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844283091200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Usher syndrome (sensorineural deafness and retinitis pigmentosa)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845566873088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic Basis of Inherited Retinal Disease in a Molecularly Characterized Cohort of More Than 3000 Families from the United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320212562048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An innovative strategy for the molecular diagnosis of Usher syndrome identifies causal biallelic mutations in 93% of European patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320216749312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Visual Prognosis in USH2A-Associated Retinitis Pigmentosa Is Worse for Patients with Usher Syndrome Type IIa Than for Those with Nonsyndromic Retinitis Pigmentosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793579258752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A combination of two truncating mutations in USH2A causes more severe and progressive hearing impairment in Usher syndrome type IIa"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795984787968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Usher protein functions in hair cells and photoreceptors"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796062992000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In Vivo Assessment of Potential Therapeutic Approaches for USH2A-Associated Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796084263168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A detailed clinical and molecular survey of subjects with nonsyndromic USH2A retinopathy reveals an allelic hierarchy of disease-causing variants"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269869909376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeted next generation sequencing for molecular diagnosis of Usher syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1524232505290210816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CLINICAL INVESTIGATION : Development of a molecular diagnostic test for Retinitis Pigmentosa in the Japanese population"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3390/ijms21217817"},{"@type":"KAKEN","@value":"PRODUCT-23594357"},{"@type":"OPENAIRE","@value":"doi_dedup___::27b527de8d02f235815b41ff755049f8"},{"@type":"CROSSREF","@value":"10.1007/s10384-023-00975-y_references_DOI_3Xsa10r6es7sFgTAFOkZaDn5SRT"}]}