{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360853567763537664.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/infdis/jiab202"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiab202/41512182/jiab202.pdf"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jid/article-pdf/225/2/317/42224259/jiab202.pdf"}},{"identifier":{"@type":"PMID","@value":"34865054"}},{"identifier":{"@type":"HANDLE","@value":"10044/1/88183"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Clonality of HIV-1– and HTLV-1–Infected Cells in Naturally Coinfected Individuals"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Coinfection with human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1) diminishes the value of the CD4+ T-cell count in diagnosing AIDS, and increases the rate of HTLV-1–associated myelopathy. It remains elusive how HIV-1/HTLV-1 coinfection is related to such characteristics. We investigated the mutual effect of HIV-1/HTLV-1 coinfection on their integration sites (ISs) and clonal expansion.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>We extracted DNA from longitudinal peripheral blood samples from 7 HIV-1/HTLV-1 coinfected, and 12 HIV-1 and 13 HTLV-1 monoinfected individuals. Proviral loads (PVL) were quantified using real-time polymerase chain reaction (PCR). Viral ISs and clonality were quantified by ligation-mediated PCR followed by high-throughput sequencing.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>PVL of both HIV-1 and HTLV-1 in coinfected individuals was significantly higher than that of the respective virus in monoinfected individuals. The degree of oligoclonality of both HIV-1– and HTLV-1–infected cells in coinfected individuals was also greater than in monoinfected subjects. ISs of HIV-1 in cases of coinfection were more frequently located in intergenic regions and transcriptionally silent regions, compared with HIV-1 monoinfected individuals.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>HIV-1/HTLV-1 coinfection makes an impact on the distribution of viral ISs and clonality of virus-infected cells and thus may alter the risks of both HTLV-1– and HIV-1–associated disease.</jats:p>\n               </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380853567763537540","@type":"Researcher","foaf:name":[{"@value":"Hiroo Katsuya"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan"},{"@value":"Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537538","@type":"Researcher","foaf:name":[{"@value":"Lucy B M Cook"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537283","@type":"Researcher","foaf:name":[{"@value":"Aileen G Rowan"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537551","@type":"Researcher","foaf:name":[{"@value":"Anat Melamed"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537289","@type":"Researcher","foaf:name":[{"@value":"Jocelyn Turpin"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326218910976","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20835540"},{"@type":"NRID","@value":"1000020835540"},{"@type":"ORCID","@value":"0000-0003-0440-8321"},{"@type":"NRID","@value":"9000412339784"},{"@type":"NRID","@value":"9000370763581"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/jampei"}],"foaf:name":[{"@value":"Jumpei Ito"}],"jpcoar:affiliationName":[{"@value":"Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537414","@type":"Researcher","foaf:name":[{"@value":"Saiful Islam"}],"jpcoar:affiliationName":[{"@value":"Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan"},{"@value":"International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537408","@type":"Researcher","foaf:name":[{"@value":"Paola Miyazato"}],"jpcoar:affiliationName":[{"@value":"Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan"},{"@value":"International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537290","@type":"Researcher","foaf:name":[{"@value":"Benjy Jek Yang Tan"}],"jpcoar:affiliationName":[{"@value":"Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan"},{"@value":"International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537668","@type":"Researcher","foaf:name":[{"@value":"Misaki Matsuo"}],"jpcoar:affiliationName":[{"@value":"Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan"},{"@value":"International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537546","@type":"Researcher","foaf:name":[{"@value":"Toshikazu Miyakawa"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537665","@type":"Researcher","foaf:name":[{"@value":"Hirotomo Nakata"}],"jpcoar:affiliationName":[{"@value":"Department of Hematology, Rheumatology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto, 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Matsushita"}],"jpcoar:affiliationName":[{"@value":"Clinical Retrovirology, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537555","@type":"Researcher","foaf:name":[{"@value":"Graham P Taylor"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537422","@type":"Researcher","foaf:name":[{"@value":"Charles R M Bangham"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567763537417","@type":"Researcher","foaf:name":[{"@value":"Shinya Kimura"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, 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[Japon]"}]},{"@id":"https://cir.nii.ac.jp/crid/1892272492897073671","@type":"Researcher","foaf:name":[{"@value":"Wellcome Trust"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273591071575552","@type":"Researcher","foaf:name":[{"@value":"The University of Tokyo (UTokyo)"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273591071575554","@type":"Researcher","foaf:name":[{"@value":"Kumamoto University"}]},{"@id":"https://cir.nii.ac.jp/crid/1892273591071575555","@type":"Researcher","foaf:name":[{"@value":"Imperial College London"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00221899"},{"@type":"EISSN","@value":"15376613"}],"prism:publicationName":[{"@value":"The Journal of Infectious Diseases"}],"dc:publisher":[{"@value":"Oxford University Press 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