{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360853567764804352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.taap.2020.115319"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0041008X20304452?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0041008X20304452?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"33160984"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Gestational arsenic exposure and paternal intergenerational epigenetic inheritance"}],"description":[{"notation":[{"@value":"A growing body of evidence has shown that gestational exposure to environmental factors such as imbalanced diet, environmental chemicals, and stress can lead to late-onset health effects in offspring and that some of these effects are heritable by the next generation and subsequent generations. Furthermore, altered epigenetic modifications in DNA methylation, histone modifications and small RNAs in a single sperm genome have been shown to transmit disease phenotypes acquired from the environment to later generations. Recently, our group found that gestational exposure of F0 pregnant dams to an inorganic arsenic, sodium arsenite, increases the incidence of hepatic tumors in male F2 mice, and the effects are paternally transmitted to the F2. Here, we first overview the epigenetic changes involved in paternal intergenerational and transgenerational inheritance caused by exposure to environmental factors. Then, we discuss our recent studies regarding paternal inheritance of the tumor-augmenting effects in F2 mice by gestational arsenite exposure, in which we investigated alterations of DNA methylation status in F2 tumors and causative F1 sperm. We also discuss the possible targets of the F2 effects. Finally, we discuss future perspectives on the studies that are needed to fully understand the health effects of arsenic exposure."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380853567764803998","@type":"Researcher","foaf:name":[{"@value":"Keiko Nohara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567764804224","@type":"Researcher","foaf:name":[{"@value":"Takehiro Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380853567764804231","@type":"Researcher","foaf:name":[{"@value":"Kazuyuki Okamura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0041008X"}],"prism:publicationName":[{"@value":"Toxicology and Applied Pharmacology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2020-12","prism:volume":"409","prism:startingPage":"115319"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0041008X20304452?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0041008X20304452?httpAccept=text/plain"}],"createdAt":"2020-11-05","modifiedAt":"2025-09-22","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Genome","dc:title":"Genome"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Methylation","dc:title":"DNA Methylation"},{"@id":"https://cir.nii.ac.jp/all?q=Arsenic","dc:title":"Arsenic"},{"@id":"https://cir.nii.ac.jp/all?q=Epigenesis,%20Genetic","dc:title":"Epigenesis, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Phenotype","dc:title":"Phenotype"},{"@id":"https://cir.nii.ac.jp/all?q=Pregnancy","dc:title":"Pregnancy"},{"@id":"https://cir.nii.ac.jp/all?q=Prenatal%20Exposure%20Delayed%20Effects","dc:title":"Prenatal Exposure Delayed Effects"},{"@id":"https://cir.nii.ac.jp/all?q=Paternal%20Inheritance","dc:title":"Paternal Inheritance"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782006393472","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K19860"},{"@type":"JGN","@value":"JP18K19860"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19860/"}],"notation":[{"@language":"ja","@value":"受精時の初期化を乗り越えて次世代胚に伝わる精子の環境因子由来DNAメチル化変化"},{"@language":"en","@value":"Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryos"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360001113987006592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA Methylation in Mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002217790544768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235487644416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome‐wide analysis of <scp>DNA</scp> methylation changes induced by gestational arsenic exposure in liver tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144447328768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Decade of 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