HLA Class II Associations With Rheumatic Heart Disease Are More Evident and Consistent Among Clinically Homogeneous Patients

DOI Web Site 2 Citations
  • Yajaira Guédez
    From the Veterans Affairs Medical Center (Y.G., M.E., M.K.) and The University of Tennessee, Departments of Surgery, Microbiology, and Immunology (Y.G., M.E., M.K.), Memphis; the Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo (A.K.) and Alexandria University (A.G., S.Z., S.K.), Egypt; and the Department of Integrative Biology, University of California, Berkeley (G.T.).
  • Alyaa Kotby
    From the Veterans Affairs Medical Center (Y.G., M.E., M.K.) and The University of Tennessee, Departments of Surgery, Microbiology, and Immunology (Y.G., M.E., M.K.), Memphis; the Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo (A.K.) and Alexandria University (A.G., S.Z., S.K.), Egypt; and the Department of Integrative Biology, University of California, Berkeley (G.T.).
  • Maha El-Demellawy
    From the Veterans Affairs Medical Center (Y.G., M.E., M.K.) and The University of Tennessee, Departments of Surgery, Microbiology, and Immunology (Y.G., M.E., M.K.), Memphis; the Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo (A.K.) and Alexandria University (A.G., S.Z., S.K.), Egypt; and the Department of Integrative Biology, University of California, Berkeley (G.T.).
  • Ashraf Galal
    From the Veterans Affairs Medical Center (Y.G., M.E., M.K.) and The University of Tennessee, Departments of Surgery, Microbiology, and Immunology (Y.G., M.E., M.K.), Memphis; the Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo (A.K.) and Alexandria University (A.G., S.Z., S.K.), Egypt; and the Department of Integrative Biology, University of California, Berkeley (G.T.).
  • Glenys Thomson
    From the Veterans Affairs Medical Center (Y.G., M.E., M.K.) and The University of Tennessee, Departments of Surgery, Microbiology, and Immunology (Y.G., M.E., M.K.), Memphis; the Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo (A.K.) and Alexandria University (A.G., S.Z., S.K.), Egypt; and the Department of Integrative Biology, University of California, Berkeley (G.T.).
  • Salah Zaher
    From the Veterans Affairs Medical Center (Y.G., M.E., M.K.) and The University of Tennessee, Departments of Surgery, Microbiology, and Immunology (Y.G., M.E., M.K.), Memphis; the Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo (A.K.) and Alexandria University (A.G., S.Z., S.K.), Egypt; and the Department of Integrative Biology, University of California, Berkeley (G.T.).
  • Samir Kassem
    From the Veterans Affairs Medical Center (Y.G., M.E., M.K.) and The University of Tennessee, Departments of Surgery, Microbiology, and Immunology (Y.G., M.E., M.K.), Memphis; the Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo (A.K.) and Alexandria University (A.G., S.Z., S.K.), Egypt; and the Department of Integrative Biology, University of California, Berkeley (G.T.).
  • Malak Kotb
    From the Veterans Affairs Medical Center (Y.G., M.E., M.K.) and The University of Tennessee, Departments of Surgery, Microbiology, and Immunology (Y.G., M.E., M.K.), Memphis; the Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo (A.K.) and Alexandria University (A.G., S.Z., S.K.), Egypt; and the Department of Integrative Biology, University of California, Berkeley (G.T.).

Bibliographic Information

Published
1999-06
DOI
  • 10.1161/01.cir.99.21.2784
Publisher
Ovid Technologies (Wolters Kluwer Health)

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Description

<jats:p> <jats:italic>Background</jats:italic> —Discrepancies in reported HLA class II associations with rheumatic heart disease (RHD) may have been due to inaccuracies of serological typing reagents and/or lack of defined clinical classification of patients analyzed. The molecular association between HLA and RHD was investigated in patients with defined clinical outcome. </jats:p> <jats:p> <jats:italic>Methods and Results</jats:italic> —Class II allele/haplotype distribution was determined in 2 groups of RHD patients (n=88) and a control group (n=59). Patients were divided into the mitral valve disease (MVD) category (ie, those with mitral regurgitation with or without mitral stenosis) and the multivalvular lesions (MVL) category, with impairment of aortic and/or tricuspid valves in addition to mitral valve damage. The MVD category (n=65) accounted for 74% of patients and included significantly fewer recurrent RF episodes compared with MVL patients ( <jats:italic>P</jats:italic> =0.002). </jats:p> <jats:p> <jats:italic>Conclusions</jats:italic> —Significant increases in DRB1*0701 and DQA1*0201 alleles and DRB1*0701-DQA1*0201 haplotypes were found in patients. Removal of the MVL patients from analysis increased the strength of HLA associations among the MVD sample. The frequency of DQA1*0103 allele was decreased and the DQB1*0603 allele was absent from the patient group, suggesting that these alleles may confer protective effects against RHD. DQ alleles in linkage disequilibrium with DR alleles appear to influence risk/protection effect: whereas the DRB1*13–DQA1*0501-3–DQB1*0301 haplotype showed a trend toward risk, the DRB1*13-DQA1*0103-DQB1*0603 haplotype was absent in the RHD sample. Our data indicate that certain class II alleles/haplotypes are associated with risk or protection from RHD and that these associations appear to be stronger and more consistent when analyzed in patients with relatively more homogeneous clinical manifestations. </jats:p>

Journal

  • Circulation

    Circulation 99 (21), 2784-2790, 1999-06

    Ovid Technologies (Wolters Kluwer Health)

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