{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360857593674940672.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41598-021-92814-8"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-021-92814-8.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-021-92814-8"}},{"identifier":{"@type":"PMID","@value":"34172819"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Serum IgG4 levels at diagnosis can predict unfavorable outcomes of untreated patients with IgG4-related disease"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The outcomes of patients with immunoglobulin G4 (IgG4)-related disease (IgG4-RD) who are not treated are unclear. This study aimed to clarify these outcomes and identify the factors related to them. We retrospectively evaluated various clinical features including laboratory data and involved organs at diagnosis in 107 patients with IgG4-RD, who were followed up for more than 6 months, at a single center in Japan. We compared the clinical features of the 27 untreated patients with those of the 80 patients treated with glucocorticoid. The patient outcomes were investigated, and logistic regression analysis was performed to identify factors related to them. The patients comprised 73 men and 34 women (median age 67 years). The untreated patients had significantly lower IgG4-RD responder index (9 vs. 12) and fewer affected organs (1 vs. 3) than did those treated with glucocorticoid. Of these 27 patients, 8 experienced deterioration of IgG4-RD after the diagnosis. In the age- and sex-adjusted logistic regression analysis, serum IgG4 elevation (per 100 mg/dL, odds ratio 1.194, 95% confidence interval 1.017–1.402) was the only significant factor related to disease deterioration in untreated patients with IgG4-RD, whereas not serum IgG4 levels (per 100 mg/dL, odds ratio 0.995, 95% confidence interval 0.921–1.075) but history of allergy (OR 3.134, 95% confidence interval 1.094–8.977, <jats:italic>P</jats:italic> = 0.033) related to deterioration in patients who underwent treatment. Serum IgG4 levels may be a useful predictor of unfavorable outcomes in untreated patients with IgG4-RD, who tend to have fewer affected organs and lower IgG4-RD responder index.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326221997056","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50645124"},{"@type":"NRID","@value":"1000050645124"},{"@type":"NRID","@value":"9000107381606"},{"@type":"NRID","@value":"9000397800490"},{"@type":"NRID","@value":"9000361321534"},{"@type":"NRID","@value":"9000413514394"},{"@type":"NRID","@value":"9000406389272"},{"@type":"NRID","@value":"9000019057920"},{"@type":"NRID","@value":"9000415037937"},{"@type":"NRID","@value":"9000022157095"},{"@type":"NRID","@value":"9000405873474"},{"@type":"NRID","@value":"9000409588599"},{"@type":"NRID","@value":"9000409588582"},{"@type":"NRID","@value":"9000403424460"},{"@type":"NRID","@value":"9000283415130"},{"@type":"NRID","@value":"9000265565987"},{"@type":"NRID","@value":"9000413481891"},{"@type":"NRID","@value":"9000359948155"},{"@type":"NRID","@value":"9000240536337"},{"@type":"NRID","@value":"9000361321482"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/i-mizu"}],"foaf:name":[{"@value":"Ichiro Mizushima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857593674940562","@type":"Researcher","foaf:name":[{"@value":"Masahiro Konishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857593674940549","@type":"Researcher","foaf:name":[{"@value":"Hajime Sanada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857593674940559","@type":"Researcher","foaf:name":[{"@value":"Kazuyuki Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857593674940548","@type":"Researcher","foaf:name":[{"@value":"Akari Takeji"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857593674940556","@type":"Researcher","foaf:name":[{"@value":"Takeshi Zoshima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857593674940417","@type":"Researcher","foaf:name":[{"@value":"Satoshi Hara"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751158640000","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10467110"},{"@type":"NRID","@value":"1000010467110"},{"@type":"NRID","@value":"9000020796848"},{"@type":"NRID","@value":"9000022712721"},{"@type":"NRID","@value":"9000361321483"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kiyoaki"}],"foaf:name":[{"@value":"Kiyoaki Ito"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751159844224","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20596895"},{"@type":"NRID","@value":"1000020596895"},{"@type":"NRID","@value":"9000237898825"},{"@type":"NRID","@value":"9000020796863"},{"@type":"NRID","@value":"9000022060931"},{"@type":"NRID","@value":"9000023166611"},{"@type":"NRID","@value":"9000022157104"},{"@type":"NRID","@value":"9000265565988"},{"@type":"NRID","@value":"9000016383565"},{"@type":"NRID","@value":"9000240536339"},{"@type":"NRID","@value":"9000022766427"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/076-265-2000"}],"foaf:name":[{"@value":"Hiroshi Fujii"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857593674940551","@type":"Researcher","foaf:name":[{"@value":"Kazunori Yamada"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276182814080","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20361983"},{"@type":"NRID","@value":"1000020361983"},{"@type":"ORCID","@value":"0000-0003-4613-2116"},{"@type":"NRID","@value":"9000107381609"},{"@type":"NRID","@value":"9000237898830"},{"@type":"NRID","@value":"9000020796891"},{"@type":"NRID","@value":"9000397800497"},{"@type":"NRID","@value":"9000237900611"},{"@type":"NRID","@value":"9000380123469"},{"@type":"NRID","@value":"9000361321548"},{"@type":"NRID","@value":"9000021258851"},{"@type":"NRID","@value":"9000290820366"},{"@type":"NRID","@value":"9000261022856"},{"@type":"NRID","@value":"9000000730851"},{"@type":"NRID","@value":"9000016383548"},{"@type":"NRID","@value":"9000411817218"},{"@type":"NRID","@value":"9000022060939"},{"@type":"NRID","@value":"9000283604004"},{"@type":"NRID","@value":"9000413514393"},{"@type":"NRID","@value":"9000406389276"},{"@type":"NRID","@value":"9000411390431"},{"@type":"NRID","@value":"9000022058748"},{"@type":"NRID","@value":"9000022062901"},{"@type":"NRID","@value":"9000003913227"},{"@type":"NRID","@value":"9000020589895"},{"@type":"NRID","@value":"9000365043764"},{"@type":"NRID","@value":"9000362203503"},{"@type":"NRID","@value":"9000405873481"},{"@type":"NRID","@value":"9000412416130"},{"@type":"NRID","@value":"9000265566047"},{"@type":"NRID","@value":"9000022836881"},{"@type":"NRID","@value":"9000409588598"},{"@type":"NRID","@value":"9000409588608"},{"@type":"NRID","@value":"9000403424465"},{"@type":"NRID","@value":"9000283415129"},{"@type":"NRID","@value":"9000265565991"},{"@type":"NRID","@value":"9000412104017"},{"@type":"NRID","@value":"9000413481890"},{"@type":"NRID","@value":"9000359948163"},{"@type":"NRID","@value":"9000323838361"},{"@type":"NRID","@value":"9000363174829"},{"@type":"NRID","@value":"9000256087970"},{"@type":"NRID","@value":"9000410959917"},{"@type":"NRID","@value":"9000240536346"},{"@type":"NRID","@value":"9000370763476"},{"@type":"NRID","@value":"9000412360130"},{"@type":"NRID","@value":"9000361321489"},{"@type":"NRID","@value":"9000256089219"},{"@type":"NRID","@value":"9000412351712"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0109465"}],"foaf:name":[{"@value":"Mitsuhiro Kawano"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20452322"}],"prism:publicationName":[{"@value":"Scientific Reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2021-06-25","prism:volume":"11","prism:number":"1"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41598-021-92814-8.pdf"},{"@id":"https://www.nature.com/articles/s41598-021-92814-8"}],"createdAt":"2021-06-25","modifiedAt":"2022-12-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoglobulin%20G","dc:title":"Immunoglobulin G"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoglobulin%20G4-Related%20Disease","dc:title":"Immunoglobulin G4-Related Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Glucocorticoids","dc:title":"Glucocorticoids"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781968816896","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K09999"},{"@type":"JGN","@value":"JP17K09999"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09999/"}],"notation":[{"@language":"ja","@value":"IgG4関連疾患における自然免疫の役割と新規治療ターゲットの探索"},{"@language":"en","@value":"The Role of Innate Immunity in IgG4-Related Diseases and the Search for Novel Therapeutic Targets"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782000590080","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K08236"},{"@type":"JGN","@value":"JP18K08236"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08236/"}],"notation":[{"@language":"ja","@value":"IgG4関連腎臓病への自然免疫の関わりの解明と新規治療ターゲットの探索"},{"@language":"en","@value":"Innate immunity mechanism in IgG4-related kidney disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256944831488","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K09083"},{"@type":"JGN","@value":"JP17K09083"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09083/"}],"notation":[{"@language":"ja","@value":"環境及び併存疾患がIgG4関連疾患の発症進展に与える影響"},{"@language":"en","@value":"Factors related to elevated serum immunoglobulin G4 (IgG4) levels and development of IgG4-related disease in a Japanese general population"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257000232064","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K17904"},{"@type":"JGN","@value":"JP19K17904"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17904/"}],"notation":[{"@language":"ja","@value":"モデルマウスを用いたIgG4関連動脈/後腹膜疾患特異的病態の解明と治療法の確立"},{"@language":"en","@value":"Elucidation of the specific pathology of IgG4-related arterial/retroperitoneal disease using model mice and establishment of treatment methods"}]},{"@id":"https://cir.nii.ac.jp/crid/1040287907244647296","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21K08473"},{"@type":"JGN","@value":"JP21K08473"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08473/"}],"notation":[{"@language":"ja","@value":"IgG4関連腎臓病における三次リンパ組織形成を介した病変進展と線維化機序の解明"},{"@language":"en","@value":"Analysis of the impact of tertiary lymphoid tissues on the development of  fibrotic inflammatory lesions in IgG4-related kidney disease"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335953713408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease: a retrospective multicenter study."}]},{"@id":"https://cir.nii.ac.jp/crid/1360002214394660608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An International Multispecialty Validation Study of the IgG4‐Related Disease Responder Index"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013171838799616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon 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