{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360857597285703296.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/ejhf.1742"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejhf.1742"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejhf.1742"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/eurjhf/article-pdf/22/3/507/66112568/eurjhf_22_3_507.pdf"}}],"dc:title":[{"@value":"Carpal Tunnel Syndrome in Cardiac Amyloidosis: Implications for Early Diagnosis and Prognostic Role Across the Spectrum of Aetiologies"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Aims</jats:title>\n                    <jats:p>We aimed to assess carpal tunnel syndrome (CTS) prevalence in transthyretin (TTR)-related and light-chain amyloidosis (AL), comparing it to the general population, adjusted for age and gender. In TTR-related amyloidosis (ATTR) we investigated (i) CTS prevalence in relation to genotype, cardiac amyloidosis (CA), age and gender; (ii) CTS role as an incremental risk factor for CA; (iii) temporal relationship between CTS and CA; and (iv) CTS prognostic role.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results</jats:title>\n                    <jats:p>Data from 538 subjects (166 hereditary ATTR, 107 wild-type ATTR, 196 AL amyloidosis, and 69 TTR mutation carriers; 64% male, median age 62.4 years), evaluated at our centre (Bologna, Italy), were analysed and compared to a published cohort of 14.9 million people, in which incidence rates of CTS had been estimated. CTS prevalence was highest in ATTR patients with CA (20.3% vs. 4.1% in the general population), while it was comparable to the general population when CA was absent and in AL patients. CTS standardized incidence rates were markedly elevated in ATTR males in the eighth decade of life (13.08 in hereditary ATTR, 15.5 in wild-type ATTR). The risk of developing CA was greater in ATTR patients with CTS; the probability of having CTS was highest 5–9 years prior to CA diagnosis. CTS was an independent mortality risk factor in ATTR.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions</jats:title>\n                    <jats:p>Compared to general population the adjusted prevalence of CTS is higher among elderly men with ATTR; CTS is a prognostic marker in ATTR, independently of cardiac involvement, and precedes CA diagnosis by 5–9 years. The awareness of this association and time delay offers the possibility of an early pre-clinical ATTR-CA diagnosis.</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380857597285703302","@type":"Researcher","foaf:name":[{"@value":"Agnese Milandri"}],"jpcoar:affiliationName":[{"@value":"Cardiology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703304","@type":"Researcher","foaf:name":[{"@value":"Andrea Farioli"}],"jpcoar:affiliationName":[{"@value":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703299","@type":"Researcher","foaf:name":[{"@value":"Christian Gagliardi"}],"jpcoar:affiliationName":[{"@value":"Cardiology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703301","@type":"Researcher","foaf:name":[{"@value":"Simone Longhi"}],"jpcoar:affiliationName":[{"@value":"Cardiology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703306","@type":"Researcher","foaf:name":[{"@value":"Fabrizio Salvi"}],"jpcoar:affiliationName":[{"@value":"Division of Neurology, IRCCS Institute of Neurological Sciences, Bellaria Hospital , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703308","@type":"Researcher","foaf:name":[{"@value":"Stefania Curti"}],"jpcoar:affiliationName":[{"@value":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703296","@type":"Researcher","foaf:name":[{"@value":"Serena Foffi"}],"jpcoar:affiliationName":[{"@value":"Cardiology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703297","@type":"Researcher","foaf:name":[{"@value":"Angelo Giuseppe Caponetti"}],"jpcoar:affiliationName":[{"@value":"Cardiology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703298","@type":"Researcher","foaf:name":[{"@value":"Massimiliano Lorenzini"}],"jpcoar:affiliationName":[{"@value":"Cardiology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna , Bologna ,"},{"@value":"University College London Institute for Cardiovascular Science and Barts Heart Centre, St. Bartholomew’s Hospital , London ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703305","@type":"Researcher","foaf:name":[{"@value":"Alessandra Ferlini"}],"jpcoar:affiliationName":[{"@value":"Section of Medical Genetics, Department of Diagnostic and Experimental Medicine, University of Ferrara , Ferrara ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703309","@type":"Researcher","foaf:name":[{"@value":"Paola Rimessi"}],"jpcoar:affiliationName":[{"@value":"Section of Medical Genetics, Department of Diagnostic and Experimental Medicine, University of Ferrara , Ferrara ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703303","@type":"Researcher","foaf:name":[{"@value":"Stefano Mattioli"}],"jpcoar:affiliationName":[{"@value":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703307","@type":"Researcher","foaf:name":[{"@value":"Francesco Saverio Violante"}],"jpcoar:affiliationName":[{"@value":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , Bologna ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857597285703300","@type":"Researcher","foaf:name":[{"@value":"Claudio Rapezzi"}],"jpcoar:affiliationName":[{"@value":"Cardiology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum, University of Bologna , Bologna ,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13889842"},{"@type":"EISSN","@value":"18790844"}],"prism:publicationName":[{"@value":"European Journal of Heart Failure"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2020-01-23","prism:volume":"22","prism:number":"3","prism:startingPage":"507","prism:endingPage":"515"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by-nc/4.0/","http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejhf.1742"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ejhf.1742"},{"@id":"https://academic.oup.com/eurjhf/article-pdf/22/3/507/66112568/eurjhf_22_3_507.pdf"}],"createdAt":"2020-01-23","modifiedAt":"2026-01-18","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013168788968448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Age-related amyloidosis outside the brain: A state-of-the-art review"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390585843968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"World Heart Federation Consensus on Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584340519812736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transthyretin amyloid deposition in ligamentum flavum (LF) is significantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal stenosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869854349416576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Distinctive Deposition Patterns of Sporadic Transthyretin-Derived Amyloidosis in the Atria: A Forensic Autopsy-Based Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390296885736942976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Reliable Baton Passing From Orthopedic Surgeon to Cardiologist　― Cardiac Screening in Patients With Carpal Tunnel Syndrome for Early Diagnosis of Transthyretin Amyloid Cardiomyopathy ―"}]},{"@id":"https://cir.nii.ac.jp/crid/1390306200186455040","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"手根管症候群におけるアミロイド陽性リスク因子の検討：ばね指治療歴の関連性"}]},{"@id":"https://cir.nii.ac.jp/crid/1390575838255079424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"External Validation of the Kumamoto Criteria in Transthyretin Amyloid Cardiomyopathy Screening　― A Retrospective Cohort Study ―"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/ejhf.1742"},{"@type":"CROSSREF","@value":"10.1016/j.arr.2021.101388_references_DOI_3nbNIq8PsvXsbwEuEmS9uBuUAun"},{"@type":"CROSSREF","@value":"10.5334/gh.1262_references_DOI_3nbNIq8PsvXsbwEuEmS9uBuUAun"},{"@type":"CROSSREF","@value":"10.5035/nishiseisai.74.612_references_DOI_3nbNIq8PsvXsbwEuEmS9uBuUAun"},{"@type":"CROSSREF","@value":"10.1038/s41598-023-47282-7_references_DOI_3nbNIq8PsvXsbwEuEmS9uBuUAun"},{"@type":"CROSSREF","@value":"10.1253/circrep.cr-22-0110_references_DOI_3nbNIq8PsvXsbwEuEmS9uBuUAun"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-23-0453_references_DOI_3nbNIq8PsvXsbwEuEmS9uBuUAun"},{"@type":"CROSSREF","@value":"10.3390/ijms25158176_references_DOI_3nbNIq8PsvXsbwEuEmS9uBuUAun"}]}