{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360861292440169472.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1055/a-1354-0367"}},{"identifier":{"@type":"URI","@value":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1354-0367.pdf"}}],"dc:title":[{"@value":"Catalytic Hydrogen Isotope Exchange Reactions in Late-Stage Functionalization"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The introduction of deuterium and tritium into molecules is of great importance in drug discovery. Many attempts have been made to develop late-stage hydrogen isotope exchange (HIE) reactions to avoid multistep syntheses using commercially available labeled precursors. In this review, we summarize recent progress in catalytic HIE reactions, with our main focus on their applications in the late-stage labeling of bioactive complex molecules and pharmaceuticals1 Introduction</jats:p><jats:p>2 \tNon-Transition-Metal-Catalyzed Hydrogen Isotope Exchange</jats:p><jats:p>2.1 \tOrganocatalysis</jats:p><jats:p>2.2 \tPhotoredox Catalysis</jats:p><jats:p>3 \tTransition-Metal-Catalyzed Hydrogen Isotope Exchang</jats:p><jats:p>3.1 \tPalladium</jats:p><jats:p>3.2 \tRuthenium</jats:p><jats:p>3.3 \tIridium</jats:p><jats:p>3.4 \tOther Metals</jats:p><jats:p>4 \tSummary</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380861292440169473","@type":"Researcher","foaf:name":[{"@value":"Hang Shi"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University"},{"@value":"Institute of Natural Sciences, Westlake Institute for Advanced Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861292440169472","@type":"Researcher","foaf:name":[{"@value":"Qi-Kai Kang"}],"jpcoar:affiliationName":[{"@value":"Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University"},{"@value":"Institute of Natural Sciences, Westlake Institute for Advanced Study"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09365214"},{"@type":"EISSN","@value":"14372096"}],"prism:publicationName":[{"@value":"Synlett"}],"dc:publisher":[{"@value":"Georg Thieme Verlag KG"}],"prism:publicationDate":"2021-01-14","prism:volume":"33","prism:number":"04","prism:startingPage":"329","prism:endingPage":"338"},"reviewed":"false","url":[{"@id":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1354-0367.pdf"}],"createdAt":"2021-01-15","modifiedAt":"2023-11-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050023085105793664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Multiple Deuterium Atom Transfer Perdeuteration of Unactivated Alkenes under Base-Assisted Cobalt/Photoredox Dual Catalysis"},{"@value":"Multiple Deuterium Atom Transfer Perdeuteration of Unactivated Alkenes under Base‐Assisted Cobalt/Photoredox Dual Catalysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016864709410048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Controlled Tetradeuteration of Straight‐Chain Fatty Acids: Synthesis, Application, and Insight into the Metabolism of Oxidized Linoleic Acid"}]},{"@id":"https://cir.nii.ac.jp/crid/2050307417131936640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent progress in the synthesis of deuterated aldehyde"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1055/a-1354-0367"},{"@type":"CROSSREF","@value":"10.1002/anie.202202779_references_DOI_620nnCSBSNK3oJdGdHST797xXkS"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20220202_references_DOI_620nnCSBSNK3oJdGdHST797xXkS"},{"@type":"CROSSREF","@value":"10.1002/anie.202500233_references_DOI_620nnCSBSNK3oJdGdHST797xXkS"}]}