{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360861292484487296.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1159/000504414"}},{"identifier":{"@type":"URI","@value":"https://www.karger.com/Article/Pdf/504414"}}],"dc:title":[{"@value":"Medication-Induced Repigmentation of Gray Hair: A Systematic Review"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Hair graying is a common sign of aging resulting from complex regulation of melanogenesis. Currently, there is no medical treatment available for hair repigmentation. In this article we review the literature on medication-induced hair repigmentation, discuss the potential mechanisms of action, and review the quality of the literary data. To date, there have been 27 studies discussing medication-induced gray hair repigmentation, including 6 articles on gray hair repigmentation as a primary objective, notably with psoralen treatment or vitamin supplementation, and 21 reports on medication-induced gray hair repigmentation as an incidental finding. Medications noted in the literature include anti-inflammatory medications (thalidomide, lenalidomide, adalimumab, acitretin, etretinate, prednisone, cyclosporin, cisplatinum, interferon-α, and psoralen), stimulators of melanogenesis (latanoprost, erlotinib, imatinib, tamoxifen, and levodopa), vitamins (calcium pantothenate and <i>para</i>-amino benzoic acid), a medication that accumulates in tissues (clofazimine), and a medication with an undetermined mechanism (captopril). Diffuse repigmentation of gray hair can be induced by certain medications that inhibit inflammation or stimulate melanogenesis. There is also low-quality evidence that some vitamin B complex supplementation can promote gray hair darkening. While these compounds are not currently indicated for the treatment of gray hair, their mechanisms shed light on targets for future medications for hair repigmentation.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380861292484487296","@type":"Researcher","foaf:name":[{"@value":"Katerina Yale"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861292484487298","@type":"Researcher","foaf:name":[{"@value":"Margit Juhasz"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861292484487297","@type":"Researcher","foaf:name":[{"@value":"Natasha Atanaskova Mesinkovska"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"22969195"},{"@type":"EISSN","@value":"22969160"}],"prism:publicationName":[{"@value":"Skin Appendage Disorders"}],"dc:publisher":[{"@value":"S. Karger AG"}],"prism:publicationDate":"2019-12-17","prism:volume":"6","prism:number":"1","prism:startingPage":"1","prism:endingPage":"10"},"reviewed":"false","dc:rights":["https://www.karger.com/Services/SiteLicenses","https://www.karger.com/Services/SiteLicenses"],"url":[{"@id":"https://www.karger.com/Article/Pdf/504414"}],"createdAt":"2019-12-17","modifiedAt":"2025-04-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360025430195233024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Protective Effect of Conditioned Medium of Immortalized Human Stem Cells from Exfoliated Deciduous Teeth Against Hair Graying Caused by X-Ray Irradiation via Its Antioxidative Activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298338420127616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Protective Effect of Hydroxygenkwanin against Hair Graying Induced by X-Ray Irradiation and Repetitive Plucking"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1159/000504414"},{"@type":"CROSSREF","@value":"10.3390/antiox14010109_references_DOI_OUa3H85xXTx5mRShvSTdYkId1iv"},{"@type":"CROSSREF","@value":"10.1016/j.xjidi.2022.100121_references_DOI_OUa3H85xXTx5mRShvSTdYkId1iv"}]}