{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360861295062052224.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41467-020-15920-7"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-020-15920-7.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-020-15920-7"}}],"dc:title":[{"@value":"Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety model induced by chronic restraint stress (CRS), the dysregulation occurs in basolateral amygdala projection neurons receiving mono-directional inputs from dorsomedial prefrontal cortex (dmPFC→BLA PNs) rather than those reciprocally connected with dmPFC (dmPFC↔BLA PNs). Specifically, CRS shifts the dmPFC-driven excitatory-inhibitory balance towards excitation in the former, but not latter population. Such specificity is preferential to connections made by dmPFC, caused by enhanced presynaptic glutamate release, and highly correlated with the increased anxiety-like behavior in stressed mice. Importantly, low-frequency optogenetic stimulation of dmPFC afferents in BLA normalizes the enhanced prefrontal glutamate release onto dmPFC→BLA PNs and lastingly attenuates CRS-induced increase of anxiety-like behavior. Our findings thus reveal a target cell-based dysregulation of mPFC-to-amygdala transmission for stress-induced anxiety.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380861295062052230","@type":"Researcher","foaf:name":[{"@value":"Wei-Zhu Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052232","@type":"Researcher","foaf:name":[{"@value":"Wen-Hua Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052231","@type":"Researcher","foaf:name":[{"@value":"Zhi-Heng Zheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052228","@type":"Researcher","foaf:name":[{"@value":"Jia-Xin Zou"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052225","@type":"Researcher","foaf:name":[{"@value":"Xiao-Xuan Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052224","@type":"Researcher","foaf:name":[{"@value":"Shou-He Huang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052227","@type":"Researcher","foaf:name":[{"@value":"Wen-Jie You"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052229","@type":"Researcher","foaf:name":[{"@value":"Ye He"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052226","@type":"Researcher","foaf:name":[{"@value":"Jun-Yu Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052233","@type":"Researcher","foaf:name":[{"@value":"Xiao-Dong Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861295062052096","@type":"Researcher","foaf:name":[{"@value":"Bing-Xing Pan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2020-05-06","prism:volume":"11","prism:number":"1","prism:startingPage":"2221"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41467-020-15920-7.pdf"},{"@id":"https://www.nature.com/articles/s41467-020-15920-7"}],"createdAt":"2020-05-06","modifiedAt":"2022-12-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360016864740798592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Long-Term Effects of Repeated Social Defeat Stress on Brain Activity during Social Interaction in BALB/c Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360300468731137536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Correlation between trait emotional intelligence and prefrontal activation during a verbal fluency task: A functional near-infrared spectroscopy study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306906095432320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Noradrenergic Regulation of the Medial Prefrontal Cortex Mediates Stress Coping in Postpartum Female Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232180975232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Prefrontal cortex is necessary for long-term social recognition memory in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707361645696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"GENETIC DELETION OF TRANSLOCATOR PROTEIN EXACERBATES POST-SEPSIS SYNDROME WITH ACTIVATION OF THE C1Q PATHWAY IN SEPTIC MOUSE MODEL"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869856031732608","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nuclei-specific abnormalities of amygdala functional connectivity and their changes after multiple types of treatments for depression: a multicenter MRI study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390297372147199360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Behavior and heart rate variability after intranasal administration of oxytocin in Holstein steers"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/s41467-020-15920-7"},{"@type":"CROSSREF","@value":"10.1523/eneuro.0068-22.2022_references_DOI_Wk0WOC8bdADaXkdMFSSMqaGP2aP"},{"@type":"CROSSREF","@value":"10.1292/jvms.22-0323_references_DOI_Wk0WOC8bdADaXkdMFSSMqaGP2aP"},{"@type":"CROSSREF","@value":"10.1097/md.0000000000034418_references_DOI_Wk0WOC8bdADaXkdMFSSMqaGP2aP"},{"@type":"CROSSREF","@value":"10.1007/s12035-024-04240-2_references_DOI_Wk0WOC8bdADaXkdMFSSMqaGP2aP"},{"@type":"CROSSREF","@value":"10.1016/j.bbr.2022.114051_references_DOI_Wk0WOC8bdADaXkdMFSSMqaGP2aP"},{"@type":"CROSSREF","@value":"10.1097/shk.0000000000002030_references_DOI_Wk0WOC8bdADaXkdMFSSMqaGP2aP"},{"@type":"CROSSREF","@value":"10.21203/rs.3.rs-5620722/v1_references_DOI_Wk0WOC8bdADaXkdMFSSMqaGP2aP"}]}