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- Frédéric N Daussin
- Université de Lille, Université d’Artois, Université de Littoral Côte d’Opale, ULR 7369 - URePSSS—Unité de Recherche Pluridisciplinaire Sport Santé Société, Lille, France
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- Elsa Heyman
- Université de Lille, Université d’Artois, Université de Littoral Côte d’Opale, ULR 7369 - URePSSS—Unité de Recherche Pluridisciplinaire Sport Santé Société, Lille, France
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- Yan Burelle
- Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ontario; and Department of Molecular and Cellular Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada
説明
<jats:title>Abstract</jats:title> <jats:p>Mitochondrial dysfunction is observed in a broad range of human diseases, including rare genetic disorders and complex acquired pathologies. For this reason, there is increasing interest in identifying safe and effective strategies to mitigate mitochondrial impairments. Natural compounds are widely used for multiple indications, and their broad healing properties suggest that several may improve mitochondrial function. This review focuses on (−)-epicatechin, a monomeric flavanol, and its effects on mitochondria. The review summarizes the available data on the effects of acute and chronic (−)-epicatechin supplementation on mitochondrial function, outlines the potential mechanisms involved in mitochondrial biogenesis induced by (−)-epicatechin supplementation and discusses some future therapeutic applications.</jats:p>
収録刊行物
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- Nutrition Reviews
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Nutrition Reviews 79 (1), 25-41, 2020-09-29
Oxford University Press (OUP)