{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360861712733083392.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/nsr/nwx062"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/nsr/article-pdf/5/2/269/31567341/nwx062.pdf"}}],"dc:title":[{"@value":"The acidic tumor microenvironment: a target for smart cancer nano-theranostics"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article, we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380861712733083394","@type":"Researcher","foaf:name":[{"@value":"Liangzhu Feng"}],"jpcoar:affiliationName":[{"@value":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861712733083392","@type":"Researcher","foaf:name":[{"@value":"Ziliang Dong"}],"jpcoar:affiliationName":[{"@value":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861712733083396","@type":"Researcher","foaf:name":[{"@value":"Danlei Tao"}],"jpcoar:affiliationName":[{"@value":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861712733083393","@type":"Researcher","foaf:name":[{"@value":"Yicheng Zhang"}],"jpcoar:affiliationName":[{"@value":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380861712733083395","@type":"Researcher","foaf:name":[{"@value":"Zhuang Liu"}],"jpcoar:affiliationName":[{"@value":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"20955138"},{"@type":"EISSN","@value":"2053714X"}],"prism:publicationName":[{"@value":"National Science Review"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2017-06-24","prism:volume":"5","prism:number":"2","prism:startingPage":"269","prism:endingPage":"286"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://academic.oup.com/nsr/article-pdf/5/2/269/31567341/nwx062.pdf"}],"createdAt":"2017-06-06","modifiedAt":"2025-06-19","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360580232414058496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Control of the stepwise self-assembly process of a pH-responsive amphiphilic 4-aminoquinoline-tetraphenylethene conjugate"}]},{"@id":"https://cir.nii.ac.jp/crid/1390588976724918144","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Screening the Human Proteome for Peptides Targeting the Acidic Environment of Tumor Tissues"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1093/nsr/nwx062"},{"@type":"CROSSREF","@value":"10.1039/d2nr05756e_references_DOI_E3bESu5EgXHPv3T67tpPFtIY8hz"},{"@type":"CROSSREF","@value":"10.1248/cpb.c25-00569_references_DOI_E3bESu5EgXHPv3T67tpPFtIY8hz"}]}