{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360865815503537664.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/gels9110866"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2310-2861/9/11/866/pdf"}},{"identifier":{"@type":"PMID","@value":"37998957"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Preparation of Cholesterol-Modified Hyaluronic Acid Nanogel-Based Hydrogel and the Inflammatory Evaluation Using Macrophage-like Cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Nanogels are candidate biomaterials for tissue engineering and drug delivery. In the present study, a cholesterol–hyaluronic acid hydrogel was developed, and the pro-inflammatory response of macrophages to the hydrogel was investigated to determine its use in biomedical applications. Hyaluronic acid modified with cholesterol (modification rate: 0–15%) and maleimide (Chol-HA) was synthesized. The Chol-HA nanogel was formed through self-assembly via hydrophobic cholesterol interactions in aqueous solution. The Chol-HA hydrogel was formed through chemical crosslinking of the Chol-HA nanogel via a Michael addition reaction between the maleimide and thiol groups of 4arm−PEGSH. We found that the Chol-HA hydrogels with 5, 10, and 15% cholesterol inhibited the pro-inflammatory response of HiBiT−THP−1 cells, suggesting that the cholesterol contributed to the macrophage response. Furthermore, Interleukin 4 (IL−4) encapsulated in the hydrogel of the Chol-HA nanogel enhanced the inhibition of the inflammatory response in HiBiT-THP-1 cells. These results provide useful insights into the biomedical applications of hydrogels.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380865815503537675","@type":"Researcher","foaf:name":[{"@value":"Kohei Yabuuchi"}],"jpcoar:affiliationName":[{"@value":"New Product Development Office, R&D Group, Healthcare Materials Division, Life Innovation SBU, Asahi Kasei Co., Chiyoda-ku, Tokyo 100-0006, Japan"},{"@value":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865815503537666","@type":"Researcher","foaf:name":[{"@value":"Mika Suzuki"}],"jpcoar:affiliationName":[{"@value":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865815503537549","@type":"Researcher","foaf:name":[{"@value":"Chen Liang"}],"jpcoar:affiliationName":[{"@value":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865815503537540","@type":"Researcher","foaf:name":[{"@value":"Yoshihide Hashimoto"}],"jpcoar:affiliationName":[{"@value":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865815503537677","@type":"Researcher","foaf:name":[{"@value":"Tsuyoshi Kimura"}],"jpcoar:affiliationName":[{"@value":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865815503537670","@type":"Researcher","foaf:name":[{"@value":"Kazunari Akiyoshi"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865815503537539","@type":"Researcher","foaf:name":[{"@value":"Akio Kishida"}],"jpcoar:affiliationName":[{"@value":"Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"23102861"}],"prism:publicationName":[{"@value":"Gels"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2023-10-31","prism:volume":"9","prism:number":"11","prism:startingPage":"866"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2310-2861/9/11/866/pdf"}],"createdAt":"2023-10-31","modifiedAt":"2025-10-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=General.%20Including%20alchemy","dc:title":"General. 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