{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360865816802499840.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/texcom/tgad010"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/cercorcomms/advance-article-pdf/doi/10.1093/texcom/tgad010/50540477/tgad010.pdf"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/cercorcomms/article-pdf/4/2/tgad010/50603387/tgad010.pdf"}},{"identifier":{"@type":"PMID","@value":"37323937"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"A possible contribution of the locus coeruleus to arousal enhancement with mild exercise: evidence from pupillometry and neuromelanin imaging"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Acute mild exercise has been observed to facilitate executive function and memory. A possible underlying mechanism of this is the upregulation of the ascending arousal system, including the catecholaminergic system originating from the locus coeruleus (LC). Prior work indicates that pupil diameter, as an indirect marker of the ascending arousal system, including the LC, increases even with very light-intensity exercise. However, it remains unclear whether the LC directly contributes to exercise-induced pupil-linked arousal. Here, we examined the involvement of the LC in the change in pupil dilation induced by very light-intensity exercise using pupillometry and neuromelanin imaging to assess the LC integrity. A sample of 21 young males performed 10 min of very light-intensity exercise, and we measured changes in the pupil diameters and psychological arousal levels induced by the exercise. Neuromelanin-weighted magnetic resonance imaging scans were also obtained. We observed that pupil diameter and psychological arousal levels increased during very light-intensity exercise, which is consistent with previous findings. Notably, the LC contrast, a marker of LC integrity, predicted the magnitude of pupil dilation and psychological arousal enhancement with exercise. These relationships suggest that the LC-catecholaminergic system is a potential a mechanism for pupil-linked arousal induced by very light-intensity exercise.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420848647286101120","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70896430"},{"@type":"NRID","@value":"1000070896430"}],"foaf:name":[{"@value":"Yudai Yamazaki"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Exercise Biochemistry and Neuroendocrinology , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"Sport Neuroscience Division , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326214448384","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80816413"},{"@type":"NRID","@value":"1000080816413"},{"@type":"NRID","@value":"9000402093460"},{"@type":"NRID","@value":"9000241680775"},{"@type":"NRID","@value":"9000404681827"},{"@type":"NRID","@value":"9000363383655"},{"@type":"NRID","@value":"9000399499568"},{"@type":"NRID","@value":"9000345295247"},{"@type":"NRID","@value":"9000413477859"},{"@type":"NRID","@value":"9000413498781"},{"@type":"NRID","@value":"9000363383568"},{"@type":"NRID","@value":"9000415307692"},{"@type":"NRID","@value":"9000406047536"},{"@type":"NRID","@value":"9000413502658"},{"@type":"NRID","@value":"9000412214308"},{"@type":"NRID","@value":"9000396149403"},{"@type":"NRID","@value":"9000398961194"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/suwabe_k"}],"foaf:name":[{"@value":"Kazuya Suwabe"}],"jpcoar:affiliationName":[{"@value":"Sport Neuroscience Division , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"Faculty of Health and Sport Sciences, Ryutsu Keizai University , 120 Ryugasaki, Ibaraki 301-0844 , Japan"},{"@value":"Center for Cybernics Research, University of Tsukuba , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573 , Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865816802499873","@type":"Researcher","foaf:name":[{"@value":"Atsuko Nagano-Saito"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Exercise Biochemistry and Neuroendocrinology , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"Sport Neuroscience Division , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"Department of Radiology, Ushiku Aiwa General Hospital , 896 Inoko-cho, Ushiku, Ibaraki 300-1296 , Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865816802499844","@type":"Researcher","foaf:name":[{"@value":"Kousaku Saotome"}],"jpcoar:affiliationName":[{"@value":"Center for Cybernics Research, University of Tsukuba , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573 , Japan"},{"@value":"Department of Radiological Sciences , School of Health Sciences, , 1 Hikarigaoka, Fukushima, Fukushima 960-1295 , Japan"},{"@value":"Fukushima Medical University , School of Health Sciences, , 1 Hikarigaoka, Fukushima, Fukushima 960-1295 , Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865816802499726","@type":"Researcher","foaf:name":[{"@value":"Ryuta Kuwamizu"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Exercise Biochemistry and Neuroendocrinology , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"Graduate School of Letters, Kyoto University , Sakyo-ku, Kyoto 606-8501 , Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865816802499846","@type":"Researcher","foaf:name":[{"@value":"Taichi Hiraga"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Exercise Biochemistry and Neuroendocrinology , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865816802499735","@type":"Researcher","foaf:name":[{"@value":"Ferenc Torma"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Exercise Biochemistry and Neuroendocrinology , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"Sport Neuroscience Division , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865816802499848","@type":"Researcher","foaf:name":[{"@value":"Kenji Suzuki"}],"jpcoar:affiliationName":[{"@value":"Center for Cybernics Research, University of Tsukuba , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573 , Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865816802499854","@type":"Researcher","foaf:name":[{"@value":"Yoshiyuki Sankai"}],"jpcoar:affiliationName":[{"@value":"Center for Cybernics Research, University of Tsukuba , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573 , Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865816802499729","@type":"Researcher","foaf:name":[{"@value":"Michael A Yassa"}],"jpcoar:affiliationName":[{"@value":"Sport Neuroscience Division , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"Department of Neurobiology and Behavior, University of California , Irvine, CA 92679-3800 , United States"},{"@value":"Center for the Neurobiology of Learning and Memory, University of California , Irvine, CA 92679-3800 , United States"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276163648384","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50221346"},{"@type":"NRID","@value":"1000050221346"},{"@type":"CINII_AUTHOR_ID","@value":"DA12050742"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA12050742#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA12050742"},{"@type":"NRID","@value":"9000016828809"},{"@type":"NRID","@value":"9000003852370"},{"@type":"NRID","@value":"9000413505441"},{"@type":"NRID","@value":"9000243891044"},{"@type":"NRID","@value":"9000410493429"},{"@type":"NRID","@value":"9000314078567"},{"@type":"NRID","@value":"9000001735101"},{"@type":"NRID","@value":"9000014219193"},{"@type":"NRID","@value":"9000363368292"},{"@type":"NRID","@value":"9000363384276"},{"@type":"NRID","@value":"9000410627241"},{"@type":"NRID","@value":"9000363382427"},{"@type":"NRID","@value":"9000363385398"},{"@type":"NRID","@value":"9000404681828"},{"@type":"NRID","@value":"9000018686444"},{"@type":"NRID","@value":"9000409322936"},{"@type":"NRID","@value":"9000414760088"},{"@type":"NRID","@value":"9000002100153"},{"@type":"NRID","@value":"9000413527926"},{"@type":"NRID","@value":"9000413527920"},{"@type":"NRID","@value":"9000006254836"},{"@type":"NRID","@value":"9000363368340"},{"@type":"NRID","@value":"9000363383253"},{"@type":"NRID","@value":"9000413475567"},{"@type":"NRID","@value":"9000413475570"},{"@type":"NRID","@value":"9000345329914"},{"@type":"NRID","@value":"9000243891174"},{"@type":"NRID","@value":"9000399499574"},{"@type":"NRID","@value":"9000381069869"},{"@type":"NRID","@value":"9000010147799"},{"@type":"NRID","@value":"9000001045967"},{"@type":"NRID","@value":"9000003850732"},{"@type":"NRID","@value":"9000363382622"},{"@type":"NRID","@value":"9000363383656"},{"@type":"NRID","@value":"9000413522909"},{"@type":"NRID","@value":"9000413522916"},{"@type":"NRID","@value":"9000020737145"},{"@type":"NRID","@value":"9000020921954"},{"@type":"NRID","@value":"9000399499569"},{"@type":"NRID","@value":"9000363166220"},{"@type":"NRID","@value":"9000363167642"},{"@type":"NRID","@value":"9000363372942"},{"@type":"NRID","@value":"9000363368346"},{"@type":"NRID","@value":"9000413510092"},{"@type":"NRID","@value":"9000413510086"},{"@type":"NRID","@value":"9000413505256"},{"@type":"NRID","@value":"9000413505261"},{"@type":"NRID","@value":"9000403870702"},{"@type":"NRID","@value":"9000380133058"},{"@type":"NRID","@value":"9000345295249"},{"@type":"NRID","@value":"9000363379269"},{"@type":"NRID","@value":"9000413477858"},{"@type":"NRID","@value":"9000413477867"},{"@type":"NRID","@value":"9000345228246"},{"@type":"NRID","@value":"9000314066617"},{"@type":"NRID","@value":"9000406051588"},{"@type":"NRID","@value":"9000410635648"},{"@type":"NRID","@value":"9000016715399"},{"@type":"NRID","@value":"9000413498777"},{"@type":"NRID","@value":"9000413472982"},{"@type":"NRID","@value":"9000314066622"},{"@type":"NRID","@value":"9000414334082"},{"@type":"NRID","@value":"9000257835032"},{"@type":"NRID","@value":"9000397811181"},{"@type":"NRID","@value":"9000397942011"},{"@type":"NRID","@value":"9000361222101"},{"@type":"NRID","@value":"9000346912319"},{"@type":"NRID","@value":"9000403905698"},{"@type":"NRID","@value":"9000414214137"},{"@type":"NRID","@value":"9000239871362"},{"@type":"NRID","@value":"9000314066653"},{"@type":"NRID","@value":"9000337094796"},{"@type":"NRID","@value":"9000018366151"},{"@type":"NRID","@value":"9000406217155"},{"@type":"NRID","@value":"9000410495406"},{"@type":"NRID","@value":"9000359883145"},{"@type":"NRID","@value":"9000363380689"},{"@type":"NRID","@value":"9000017192082"},{"@type":"NRID","@value":"9000380133079"},{"@type":"NRID","@value":"9000345376676"},{"@type":"NRID","@value":"9000345228779"},{"@type":"NRID","@value":"9000253661793"},{"@type":"NRID","@value":"9000253235721"},{"@type":"NRID","@value":"9000010638629"},{"@type":"NRID","@value":"9000363380192"},{"@type":"NRID","@value":"9000363379274"},{"@type":"NRID","@value":"9000363383457"},{"@type":"NRID","@value":"9000363383571"},{"@type":"NRID","@value":"9000283506583"},{"@type":"NRID","@value":"9000333198548"},{"@type":"NRID","@value":"9000363167127"},{"@type":"NRID","@value":"9000016656823"},{"@type":"NRID","@value":"9000363367320"},{"@type":"NRID","@value":"9000243890866"},{"@type":"NRID","@value":"9000406047538"},{"@type":"NRID","@value":"9000406047441"},{"@type":"NRID","@value":"9000010186907"},{"@type":"NRID","@value":"9000001031345"},{"@type":"NRID","@value":"9000003228674"},{"@type":"NRID","@value":"9000021244828"},{"@type":"NRID","@value":"9000380133455"},{"@type":"NRID","@value":"9000399447697"},{"@type":"NRID","@value":"9000018214664"},{"@type":"NRID","@value":"9000375851781"},{"@type":"NRID","@value":"9000363379576"},{"@type":"NRID","@value":"9000413502650"},{"@type":"NRID","@value":"9000020921867"},{"@type":"NRID","@value":"9000020800516"},{"@type":"NRID","@value":"9000412668862"},{"@type":"NRID","@value":"9000345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Soya"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Exercise Biochemistry and Neuroendocrinology , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Faculty of Health and Sport Sciences, , 1-1-1 Tannoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"Sport Neuroscience Division , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"},{"@value":"University of Tsukuba , Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, , 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8574 , Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"26327376"}],"prism:publicationName":[{"@value":"Cerebral Cortex Communications"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2023","prism:volume":"4","prism:number":"2","prism:startingPage":"tgad010"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://academic.oup.com/cercorcomms/advance-article-pdf/doi/10.1093/texcom/tgad010/50540477/tgad010.pdf"},{"@id":"https://academic.oup.com/cercorcomms/article-pdf/4/2/tgad010/50603387/tgad010.pdf"}],"createdAt":"2023-06-08","modifiedAt":"2023-06-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Original%20Article","dc:title":"Original Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040287907239603584","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21K17619"},{"@type":"JGN","@value":"JP21K17619"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K17619/"}],"notation":[{"@language":"ja","@value":"慢性ストレスおよび抑うつ状態は運動時ヒト海馬活動のバラツキを生むか？"},{"@language":"en","@value":"Do Chronic Stress and Depressive States Contribute to Variability in Hippocampal Activity During Exercise in Humans?"}]},{"@id":"https://cir.nii.ac.jp/crid/1040569382219834112","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21H04858"},{"@type":"JGN","@value":"JP21H04858"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04858/"}],"notation":[{"@language":"ja","@value":"運動が海馬機能を増強するメカニズムの統合的解明：動物からヒトへの橋渡し研究"},{"@language":"en","@value":"Integrative elucidation of the mechanism by which exercise enhances hippocampal function: A translational study from animals to humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1040854882539435136","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22K17808"},{"@type":"JGN","@value":"JP22K17808"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K17808/"}],"notation":[{"@language":"ja","@value":"運動時fMRIで探る超低強度運動が気分と認知を高める脳内メカニズム"},{"@language":"en","@value":"Neural mechanisms of the effects of very light intensity exercise on mood and cognitive function: an fMRI study"}]},{"@id":"https://cir.nii.ac.jp/crid/1040858829284747904","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22KJ0341"},{"@type":"JGN","@value":"JP22KJ0341"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KJ0341/"}],"notation":[{"@language":"ja","@value":"3つの脳相互作用から有酸素性運動の効果を紐解く"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050015333084076288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pupil dynamics during very light exercise predict benefits to prefrontal cognition"}]},{"@id":"https://cir.nii.ac.jp/crid/1050575760877087488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pupil-linked arousal with very light exercise: pattern of pupil dilation during graded exercise"}]},{"@id":"https://cir.nii.ac.jp/crid/1050584431796907648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Light-exercise-induced dopaminergic and noradrenergic stimulation in the dorsal hippocampus: Using a rat physiological exercise model"},{"@value":"Light‐exercise‐induced dopaminergic and noradrenergic stimulation in the dorsal hippocampus: Using a rat physiological exercise model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233964608512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Rapid stimulation of human dentate gyrus function with acute mild exercise"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144621514880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: 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