{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360865818722017536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/bjh.15805"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbjh.15805"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.15805"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bjh.15805"}}],"dc:title":[{"@value":"Life expectancy of follicular lymphoma patients in complete response at 30 months is similar to that of the Spanish general population"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p>The use of immunochemotherapy has improved the outcome of follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL</jats:styled-content>). Recently, complete response at 30 months (<jats:styled-content style=\"fixed-case\">CR</jats:styled-content>30) has been suggested as a surrogate for progression‐free survival. This study aimed to analyse the life expectancy of <jats:styled-content style=\"fixed-case\">FL</jats:styled-content> patients according to their status at 30 months from the start of treatment in comparison with the sex and age‐matched Spanish general population (relative survival; <jats:styled-content style=\"fixed-case\">RS</jats:styled-content>). The training series comprised 263 patients consecutively diagnosed with <jats:styled-content style=\"fixed-case\">FL</jats:styled-content> in a 10‐year period who needed therapy and were treated with rituximab‐containing regimens. An independent cohort of 693 <jats:styled-content style=\"fixed-case\">FL</jats:styled-content> patients from the Grupo Español de Linfomas y Trasplante Autólogo de Médula Ósea (<jats:styled-content style=\"fixed-case\">GELTAMO</jats:styled-content>) group was used for validation. In the training cohort, 188 patients were in <jats:styled-content style=\"fixed-case\">CR</jats:styled-content>30, with a 10‐year overall survival (<jats:styled-content style=\"fixed-case\">OS</jats:styled-content>) of 53% and 87% for non‐<jats:styled-content style=\"fixed-case\">CR</jats:styled-content>30 and <jats:styled-content style=\"fixed-case\">CR</jats:styled-content>30 patients, respectively. Ten‐year <jats:styled-content style=\"fixed-case\">RS</jats:styled-content> was 73% and 100%, showing no decrease in life expectancy for <jats:styled-content style=\"fixed-case\">CR</jats:styled-content>30 patients. Multivariate analysis indicated that the <jats:styled-content style=\"fixed-case\">FL</jats:styled-content> International Prognostic Index was the most important variable predicting <jats:styled-content style=\"fixed-case\">OS</jats:styled-content> in the <jats:styled-content style=\"fixed-case\">CR</jats:styled-content>30 group. The impact of <jats:styled-content style=\"fixed-case\">CR</jats:styled-content>30 status on <jats:styled-content style=\"fixed-case\">RS</jats:styled-content> was validated in the independent <jats:styled-content style=\"fixed-case\">GELTAMO</jats:styled-content> series. In conclusion, <jats:styled-content style=\"fixed-case\">FL</jats:styled-content> patients treated with immunochemotherapy who were in <jats:styled-content style=\"fixed-case\">CR</jats:styled-content> at 30 months showed similar survival to a sex‐ and age‐matched Spanish general population.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380865818722017556","@type":"Researcher","foaf:name":[{"@value":"Laura Magnano"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Clínic de Barcelona Barcelona Spain"},{"@value":"CIBERONC Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017560","@type":"Researcher","foaf:name":[{"@value":"Sara Alonso‐Alvarez"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Universitario de Salamanca and IBSAL Salamanca Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017537","@type":"Researcher","foaf:name":[{"@value":"Miguel Alcoceba"}],"jpcoar:affiliationName":[{"@value":"CIBERONC Madrid Spain"},{"@value":"Haematology Department Hospital Universitario de Salamanca and IBSAL Salamanca Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017539","@type":"Researcher","foaf:name":[{"@value":"Alfredo Rivas‐Delgado"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Clínic de Barcelona Barcelona Spain"},{"@value":"CIBERONC Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017546","@type":"Researcher","foaf:name":[{"@value":"Anna Muntañola"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Universitario Mutua de Terrassa Terrassa Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017550","@type":"Researcher","foaf:name":[{"@value":"Ferran Nadeu"}],"jpcoar:affiliationName":[{"@value":"Lymphoid Neoplasms Program Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017548","@type":"Researcher","foaf:name":[{"@value":"Xavier Setoain"}],"jpcoar:affiliationName":[{"@value":"Nuclear Medicine Department Hospital Clinic de Barcelona, Barcelona Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER‐BBN)2 Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017569","@type":"Researcher","foaf:name":[{"@value":"Sonia Rodríguez"}],"jpcoar:affiliationName":[{"@value":"Nuclear Medicine Department Hospital Clinic de Barcelona, Barcelona Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER‐BBN)2 Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017557","@type":"Researcher","foaf:name":[{"@value":"Marcio Andrade‐Campos"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Miguel Servet Zaragoza Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017536","@type":"Researcher","foaf:name":[{"@value":"Natalia Espinosa‐Lara"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Miguel Servet Zaragoza Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017559","@type":"Researcher","foaf:name":[{"@value":"Guillermo Rodríguez"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Virgen del Rocío Sevilla Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017549","@type":"Researcher","foaf:name":[{"@value":"Juan Manuel Sancho"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital GermansTrias i Pujol (ICO‐IJC) Badalona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017552","@type":"Researcher","foaf:name":[{"@value":"Miriam Moreno"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital GermansTrias i Pujol (ICO‐IJC) Badalona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017553","@type":"Researcher","foaf:name":[{"@value":"Santiago Mercadal"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Duran i Reynals (ICO) Hospitalet Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017570","@type":"Researcher","foaf:name":[{"@value":"Itziar Carro"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Duran i Reynals (ICO) Hospitalet Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017551","@type":"Researcher","foaf:name":[{"@value":"Antonio Salar"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital del Mar Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017544","@type":"Researcher","foaf:name":[{"@value":"Francesc Garcia‐Pallarols"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital del Mar Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017558","@type":"Researcher","foaf:name":[{"@value":"Reyes Arranz"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital de la Princesa Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017547","@type":"Researcher","foaf:name":[{"@value":"Jimena Cannata"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital de la Princesa Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017554","@type":"Researcher","foaf:name":[{"@value":"María J. Terol"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Clínico de Valencia Valencia Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017563","@type":"Researcher","foaf:name":[{"@value":"Ana I. Teruel"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Clínico de Valencia Valencia Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017543","@type":"Researcher","foaf:name":[{"@value":"Ana Jiménez‐Ubieto"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital 12 de Octubre Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017542","@type":"Researcher","foaf:name":[{"@value":"Antonia Rodriguez"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital 12 de Octubre Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017568","@type":"Researcher","foaf:name":[{"@value":"Sonia González de Villambrosía"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Valdecilla Santander Santander Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017561","@type":"Researcher","foaf:name":[{"@value":"José L. Bello"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital de Nuestra Señora de la Esperanza Santiago de Compostela Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017562","@type":"Researcher","foaf:name":[{"@value":"Lourdes López"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital MD Anderson Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017555","@type":"Researcher","foaf:name":[{"@value":"Silvana Novelli"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Sant Pau Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017540","@type":"Researcher","foaf:name":[{"@value":"Erik de Cabo"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital del Bierzo Ponferrada Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017565","@type":"Researcher","foaf:name":[{"@value":"María E. Infante"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Infanta Leonor Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017566","@type":"Researcher","foaf:name":[{"@value":"Emilia Pardal"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Virgen del Puerto Plasencia Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017538","@type":"Researcher","foaf:name":[{"@value":"Silvia Monsalvo"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Fundación Jiménez Díaz Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017567","@type":"Researcher","foaf:name":[{"@value":"Marcos González"}],"jpcoar:affiliationName":[{"@value":"CIBERONC Madrid Spain"},{"@value":"Haematology Department Hospital Universitario de Salamanca and IBSAL Salamanca Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017541","@type":"Researcher","foaf:name":[{"@value":"Alejandro Martín"}],"jpcoar:affiliationName":[{"@value":"CIBERONC Madrid Spain"},{"@value":"Haematology Department Hospital Universitario de Salamanca and IBSAL Salamanca Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017545","@type":"Researcher","foaf:name":[{"@value":"M. Dolores Caballero"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Clínic de Barcelona Barcelona Spain"},{"@value":"CIBERONC Madrid Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380865818722017564","@type":"Researcher","foaf:name":[{"@value":"Armando López‐Guillermo"}],"jpcoar:affiliationName":[{"@value":"Haematology Department Hospital Clínic de Barcelona Barcelona Spain"},{"@value":"CIBERONC Madrid Spain"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00071048"},{"@type":"EISSN","@value":"13652141"}],"prism:publicationName":[{"@value":"British Journal of Haematology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-02-22","prism:volume":"185","prism:number":"3","prism:startingPage":"480","prism:endingPage":"491"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbjh.15805"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.15805"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bjh.15805"}],"createdAt":"2019-02-22","modifiedAt":"2023-09-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360302865536891136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Robust prognostic value of histologic transformation in patients with early progression of follicular lymphoma"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/bjh.15805"},{"@type":"CROSSREF","@value":"10.1080/10428194.2023.2226429_references_DOI_M8o8t43KSfmMwUmOcrTrED7JX8o"}]}