{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360865821074875520.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.abo3627"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.abo3627"}},{"identifier":{"@type":"PMID","@value":"36538032"}},{"identifier":{"@type":"HANDLE","@value":"2445/202161"}},{"identifier":{"@type":"HANDLE","@value":"10261/288951"}},{"identifier":{"@type":"HANDLE","@value":"20.500.11768/150986"}},{"identifier":{"@type":"HANDLE","@value":"10230/56278"}},{"identifier":{"@type":"HANDLE","@value":"2108/321968"}},{"identifier":{"@type":"HANDLE","@value":"11585/950748"}},{"identifier":{"@type":"HANDLE","@value":"1854/LU-01GW77JSBQS6Z0J85C7X7WJ2V6"}},{"identifier":{"@type":"HANDLE","@value":"10356/172159"}}],"dc:title":[{"@value":"Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children"}],"description":[{"type":"abstract","notation":[{"@value":"\n Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of\n OAS1\n ,\n OAS2\n , or\n RNASEL\n in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)–sensing OAS1 and OAS2 generate 2′-5′-linked oligoadenylates (2-5A) that activate the single-stranded RNA–degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L–deficient cells. Cytokine production in RNase L–deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS–RNase L deficiencies in these patients unleash the production of SARS-CoV-2–triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C.\n "}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380865821074875858","@type":"Researcher","foaf:name":[{"@value":"Danyel Lee"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."},{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875462","@type":"Researcher","foaf:name":[{"@value":"Jérémie Le Pen"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875844","@type":"Researcher","foaf:name":[{"@value":"Ahmad Yatim"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875289","@type":"Researcher","foaf:name":[{"@value":"Beihua Dong"}],"jpcoar:affiliationName":[{"@value":"Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875610","@type":"Researcher","foaf:name":[{"@value":"Yann Aquino"}],"jpcoar:affiliationName":[{"@value":"Human Evolutionary Genetics Unit, Institut Pasteur, Paris City University, CNRS UMR 2000, Paris, France."},{"@value":"Doctoral College, Sorbonne University, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875669","@type":"Researcher","foaf:name":[{"@value":"Masato Ogishi"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875417","@type":"Researcher","foaf:name":[{"@value":"Rémi Pescarmona"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Immunology, Lyon Sud Hospital, Lyon, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875681","@type":"Researcher","foaf:name":[{"@value":"Estelle Talouarn"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875776","@type":"Researcher","foaf:name":[{"@value":"Darawan Rinchai"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875264","@type":"Researcher","foaf:name":[{"@value":"Peng Zhang"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875434","@type":"Researcher","foaf:name":[{"@value":"Magali Perret"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Immunology, Lyon Sud Hospital, Lyon, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875842","@type":"Researcher","foaf:name":[{"@value":"Zhiyong Liu"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875455","@type":"Researcher","foaf:name":[{"@value":"Iolanda Jordan"}],"jpcoar:affiliationName":[{"@value":"Pediatric Intensive Care Department, Hospital Sant Joan de Déu, Barcelona, Spain."},{"@value":"Kids Corona Platform, Barcelona, Spain."},{"@value":"Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain."},{"@value":"Department of Surgery and Surgical Specializations, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain."},{"@value":"Respiratory and Immunological Dysfunction in Pediatric Critically Ill Patients, Institute of Recerca Sant Joan de Déu, Barcelona, Spain."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875440","@type":"Researcher","foaf:name":[{"@value":"Sefika Elmas Bozdemir"}],"jpcoar:affiliationName":[{"@value":"Bursa City Hospital, Bursa, Turkey."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875789","@type":"Researcher","foaf:name":[{"@value":"Gulsum Iclal Bayhan"}],"jpcoar:affiliationName":[{"@value":"Ankara City Hospital, Yildirim Beyazit University, Ankara, Turkey."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875815","@type":"Researcher","foaf:name":[{"@value":"Camille Beaufils"}],"jpcoar:affiliationName":[{"@value":"Immunology and Rheumatology Division, Department of Pediatrics, University of Montreal, CHU Sainte-Justine, Montreal, QC, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875780","@type":"Researcher","foaf:name":[{"@value":"Lucy Bizien"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875532","@type":"Researcher","foaf:name":[{"@value":"Aurelie Bisiaux"}],"jpcoar:affiliationName":[{"@value":"Human Evolutionary Genetics Unit, Institut Pasteur, Paris City University, CNRS UMR 2000, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875594","@type":"Researcher","foaf:name":[{"@value":"Weite Lei"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875682","@type":"Researcher","foaf:name":[{"@value":"Milena Hasan"}],"jpcoar:affiliationName":[{"@value":"Center for Translational Research, Institut Pasteur, Paris City University, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875290","@type":"Researcher","foaf:name":[{"@value":"Jie Chen"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875408","@type":"Researcher","foaf:name":[{"@value":"Christina Gaughan"}],"jpcoar:affiliationName":[{"@value":"Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875540","@type":"Researcher","foaf:name":[{"@value":"Abhishek Asthana"}],"jpcoar:affiliationName":[{"@value":"Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875784","@type":"Researcher","foaf:name":[{"@value":"Valentina Libri"}],"jpcoar:affiliationName":[{"@value":"Center for Translational Research, Institut Pasteur, Paris City University, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875793","@type":"Researcher","foaf:name":[{"@value":"Joseph M. Luna"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA."},{"@value":"Department of Biochemistry and Center for RNA Science and Therapeutics, Case Western Reserve University, Cleveland, OH, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875413","@type":"Researcher","foaf:name":[{"@value":"Fabrice Jaffré"}],"jpcoar:affiliationName":[{"@value":"Department of Surgery, Weill Cornell Medical College, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875543","@type":"Researcher","foaf:name":[{"@value":"H.-Heinrich Hoffmann"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875568","@type":"Researcher","foaf:name":[{"@value":"Eleftherios Michailidis"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA."},{"@value":"Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875433","@type":"Researcher","foaf:name":[{"@value":"Marion Moreews"}],"jpcoar:affiliationName":[{"@value":"International Center of Infectiology Research (CIRI), University of Lyon, INSERM U1111, Claude Bernard University, Lyon 1, CNRS, UMR5308, ENS of Lyon, Lyon, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875670","@type":"Researcher","foaf:name":[{"@value":"Yoann Seeleuthner"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875562","@type":"Researcher","foaf:name":[{"@value":"Kaya Bilguvar"}],"jpcoar:affiliationName":[{"@value":"Departments of Neurosurgery and Genetics and Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA."},{"@value":"Department of Medical Genetics, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875689","@type":"Researcher","foaf:name":[{"@value":"Shrikant Mane"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875283","@type":"Researcher","foaf:name":[{"@value":"Carlos Flores"}],"jpcoar:affiliationName":[{"@value":"Research Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain."},{"@value":"Genomics Division, Institute of Technology and Renewable Energies (ITER), Granadilla de Abona, Spain."},{"@value":"CIBERES, ISCIII, Madrid, Spain."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875802","@type":"Researcher","foaf:name":[{"@value":"Yu Zhang"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA."},{"@value":"NIAID Clinical Genomics Program, NIH, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875578","@type":"Researcher","foaf:name":[{"@value":"Andrés A. Arias"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."},{"@value":"Primary Immunodeficiencies Group, University of Antioquia (UdeA), Medellin, Colombia."},{"@value":"School of Microbiology, University of Antioquia (UdeA), Medellin, Colombia."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875855","@type":"Researcher","foaf:name":[{"@value":"Rasheed Bailey"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875548","@type":"Researcher","foaf:name":[{"@value":"Agatha Schlüter"}],"jpcoar:affiliationName":[{"@value":"Neurometabolic Diseases Laboratory, IDIBELL–Hospital Duran I Reynals, CIBERER U759, ISIiii, Madrid, Spain."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875554","@type":"Researcher","foaf:name":[{"@value":"Baptiste Milisavljevic"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875451","@type":"Researcher","foaf:name":[{"@value":"Benedetta Bigio"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875544","@type":"Researcher","foaf:name":[{"@value":"Tom Le Voyer"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875690","@type":"Researcher","foaf:name":[{"@value":"Marie Materna"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875529","@type":"Researcher","foaf:name":[{"@value":"Adrian Gervais"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875412","@type":"Researcher","foaf:name":[{"@value":"Marcela Moncada-Velez"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875823","@type":"Researcher","foaf:name":[{"@value":"Francesca Pala"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875811","@type":"Researcher","foaf:name":[{"@value":"Tomi Lazarov"}],"jpcoar:affiliationName":[{"@value":"Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875783","@type":"Researcher","foaf:name":[{"@value":"Romain Levy"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875469","@type":"Researcher","foaf:name":[{"@value":"Anna-Lena Neehus"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875467","@type":"Researcher","foaf:name":[{"@value":"Jérémie Rosain"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France."},{"@value":"Paris City University, Imagine Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875777","@type":"Researcher","foaf:name":[{"@value":"Jessica Peel"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875847","@type":"Researcher","foaf:name":[{"@value":"Yi-Hao Chan"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875427","@type":"Researcher","foaf:name":[{"@value":"Marie-Paule Morin"}],"jpcoar:affiliationName":[{"@value":"Immunology and Rheumatology Division, Department of Pediatrics, University of Montreal, CHU Sainte-Justine, Montreal, QC, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875675","@type":"Researcher","foaf:name":[{"@value":"Rosa Maria Pino-Ramirez"}],"jpcoar:affiliationName":[{"@value":"Pediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875439","@type":"Researcher","foaf:name":[{"@value":"Serkan Belkaya"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875563","@type":"Researcher","foaf:name":[{"@value":"Lazaro Lorenzo"}],"jpcoar:affiliationName":[{"@value":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875849","@type":"Researcher","foaf:name":[{"@value":"Jordi Anton"}],"jpcoar:affiliationName":[{"@value":"Department of Surgery and Surgical Specializations, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain."},{"@value":"Pediatric Rheumatology Division, Hospital Sant Joan de Déu, Barcelona, Spain."},{"@value":"Study Group for Immune Dysfunction Diseases in Children (GEMDIP), Institute of Recerca Sant Joan de Déu, Barcelona, Spain."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875674","@type":"Researcher","foaf:name":[{"@value":"Selket Delafontaine"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875535","@type":"Researcher","foaf:name":[{"@value":"Julie Toubiana"}],"jpcoar:affiliationName":[{"@value":"Department of General Pediatrics and Pediatric Infectious Diseases, Necker Hospital for Sick Children, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris City University, Paris, France."},{"@value":"Biodiversity and Epidemiology of Bacterial Pathogens, Pasteur Institute, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875456","@type":"Researcher","foaf:name":[{"@value":"Fanny Bajolle"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatric Cardiology, Necker Hospital for Sick Children, AP-HP, Paris City University, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875843","@type":"Researcher","foaf:name":[{"@value":"Victoria Fumadó"}],"jpcoar:affiliationName":[{"@value":"Kids Corona Platform, Barcelona, Spain."},{"@value":"Department of Surgery and Surgical Specializations, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain."},{"@value":"Pediatrics Infectious Diseases Division, Hospital Sant Joan de Déu, Barcelona, Spain."},{"@value":"Infectious Diseases and Microbiome, Institute of Recerca Sant Joan de Déu, Barcelona, Spain."}]},{"@id":"https://cir.nii.ac.jp/crid/1380865821074875692","@type":"Researcher","foaf:name":[{"@value":"Marta L. 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Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643331","@type":"Researcher","foaf:name":[{"@value":"Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642971","@type":"Researcher","foaf:name":[{"@value":"Centre d'Investigation Clinique [Rennes] (CIC) ; Université de Rennes (UR)-Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]-Institut National de la Santé et de la Recherche Médicale (INSERM)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643076","@type":"Researcher","foaf:name":[{"@value":"The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364 and R21AI160576), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1TR001866), the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the Yale High-Performance Computing Center (S10OD018521), the Fisher Center for Alzheimer’s Research Foundation, the Meyer Foundation, the JBP Foundation, the French National Research Agency (ANR) under the “Investments for the Future” program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the ANR GenMISC (ANR-21-COVR-039), the ANRS-COV05, ANR GENVIR (ANR-20-CE93-003) and ANR AABIFNCOV (ANR-20-CO11-0001) projects, the ANR-RHU program (ANR-21-RHUS-08), the European Union’s Horizon 2020 research and innovation program under grant agreement 824110 (EASI-genomics), the HORIZON-HLTH-2021-DISEASE-04 program under grant agreement 01057100 (UNDINE), the ANR-RHU Program ANR-21-RHUS-08 (COVIFERON), the Square Foundation, Grandir – Fonds de solidarité pour l’enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Science, the French Ministry of Higher Education, Research, and Innovation (MESRI-COVID-19), Institut National de la Santé et de la Recherche Médicale (INSERM), and Paris Cité University. We acknowledge support from the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH under award R01AI104887 to R.H.S. and S.R.W. The Laboratory of Human Evolutionary Genetics (Institut Pasteur) is supported by the Institut Pasteur, the Collège de France, the French Government’s Investissement d’Avenir program, Laboratoires d’Excellence “Integrative Biology of Emerging Infectious Diseases” (ANR-10-LABX-62-IBEID) and “Milieu Intérieur” (ANR-10-LABX-69-01), the Fondation de France (no. 00106080), the FRM (Equipe FRM DEQ20180339214 team), and the ANR COVID-19-POPCELL (ANR-21-CO14-0003-01). A.Puj. is supported by ACCI20-759 CIBERER, EasiGenomics H2020 Marató TV3 COVID 2021-31-33, the HORIZON-HLTH-2021-ID: 101057100 (UNDINE), the Horizon 2020 program under grant no. 824110 (EasiGenomics grant no. COVID-19/PID12342), and the CERCA Program/Generalitat de Catalunya. The Canarian Health System sequencing hub was funded by the Instituto de Salud Carlos III (COV20_01333 and COV20_01334), the Spanish Ministry of Science and Innovation (RTC-2017-6471-1; AEI/FEDER, UE), Fundación MAPFRE Guanarteme (OA21/131), and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”). The CoV-Contact Cohort was funded by the French Ministry of Health and the European Commission (RECOVER project). Our studies are also funded by the Ministry of Health of the Czech Republic Conceptual Development of Research Organization (FNBr, 65269705) and ANID COVID0999 funding in Chile. G. Novelli and A. Novelli are supported by Regione Lazio (Research Group Projects 2020) No. A0375-2020-36663, GecoBiomark. A.M.P., M.L.D., and J.P.-T. are supported by the Inmungen-CoV2 project of CSIC. This work was supported in part by the Intramural Research Program of the NIAID, NIH. The research work of A.M.P, M.L.D., and J.P.-T. was funded by the European Commission –NextGenerationEU (Regulation EU 2020/2094), through CSIC’s Global Health Platform (PTI Salud Global). I.M. is a senior clinical investigator at FWO Vlaanderen supported by a VIB GC PID grant, by FWO grants G0B5120N (DADA2) and G0E8420N, and by the Jeffrey Modell Foundation. I.M. holds an ERC-StG MORE2ADA2 grant and is also supported by ERN-RITA.​ A.Y. is supported by fellowships from the European Academy of Dermatology and Venereology and the Swiss National Science Foundation and by an Early Career Award from the Thrasher Research Fund. Y.-H.C. is supported by an A*STAR International Fellowship (AIF). M.O. was supported by the David Rockefeller Graduate Program, the New York Hideyo Noguchi Memorial Society (HNMS), the Funai Foundation for Information Technology (FFIT), the Honjo International Scholarship Foundation (HISF), and the National Cancer Institute (NCI) F99 Award (F99CA274708). A.A.A. was supported by Ministerio de Ciencia Tecnología e Innovación MINCIENCIAS, Colombia (111584467551/CT 415-2020). D.L. is supported by a fellowship from the FRM for medical residents and fellows. E.H. received funding from the Bank of Montreal Chair of Pediatric Immunology, Foundation of CHU Sainte-Justine, CIHR grants PCC-466901 and MM1-181123, and a Canadian Pediatric Society IMPACT study. Q.P.-H. received funding from the European Union’s Horizon 2020 research and innovation program (ATAC, 101003650), the Swedish Research Council, and the Knut and Alice Wallenberg Foundation. Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, R01AI091707-10S1, and R01AI161444; a George Mason University Fast Grant; the G. Harold and Leila Y. Mathers Charitable Foundation; the Meyer Foundation; and the Bawd Foundation. R.P.L. is on the board of directors of both Roche and the Roche subsidiary Genentech. J.L.P. was supported by a Francois Wallace Monahan Postdoctoral Fellowship at the Rockefeller University and by a European Molecular Biology Organization Long-Term Fellowship (ALTF 380-2018)."}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643751","@type":"Researcher","foaf:name":[{"@value":"ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340644006","@type":"Researcher","foaf:name":[{"@value":"ANR-21-COVR-0039,GenMIS-C,Recherche des Déficits immunitaires innées monogéniques prédisposant au syndrome inflammatoire multisystémique chez l'enfant.(2021)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643727","@type":"Researcher","foaf:name":[{"@value":"ANR-20-CE93-0003,GENVIR,Analyse multi-omique de l'immunité anti-virale: de l'identification des circuits biologiques pertinents à la découverte de défauts monogéniques héréditaires de l'immunité chez les patients avec infections virales sévères(2020)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643995","@type":"Researcher","foaf:name":[{"@value":"ANR-20-CO11-0001,AABIFNCOV,Bases génétiques et immunologiques des auto-anticorps contre les interférons de type I prédisposant aux formes sévères de COVID-19.(2020)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643340","@type":"Researcher","foaf:name":[{"@value":"ANR-10-IAHU-0001,Imagine,Institut Hospitalo-Universitaire Imagine(2010)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643603","@type":"Researcher","foaf:name":[{"@value":"ANR-21-RHUS-0008,COVIFERON,Covid-19 and interferons: from discovery to therapy(2021)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642854","@type":"Researcher","foaf:name":[{"@value":"ANR-21-CO14-0003,COVID-19-POPCELL,Facteurs génétiques et infectieux à l'origine de la variabilité populationnelle de la réponse immunitaire à l'infection par le SARS-CoV-2(2021)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643374","@type":"Researcher","foaf:name":[{"@value":"ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642723","@type":"Researcher","foaf:name":[{"@value":"European Project: 101057100,HORIZON-HLTH-2021-DISEASE-04 ,UNDINE(2022)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642818","@type":"Researcher","foaf:name":[{"@value":"European Project: 824110,H2020-INFRAIA-2018-1,EASI-Genomics(2019)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642988","@type":"Researcher","foaf:name":[{"@value":"A*STAR Infectious Disease Lab"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642961","@type":"Researcher","foaf:name":[{"@value":"Pérez-Tur, Jordi"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643218","@type":"Researcher","foaf:name":[{"@value":"Lee Kong Chian School of Medicine (LKCMedicine)"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340644096","@type":"Researcher","foaf:name":[{"@value":"School of Biological Sciences"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643469","@type":"Researcher","foaf:name":[{"@value":"Centre International de Recherche en Infectiologie (CIRI) ; École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Université de Lyon-Université Jean Monnet - 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We acknowledge support from the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH under award R01AI104887 to R.H.S. and S.R.W. The Laboratory of Human Evolutionary Genetics (Institut Pasteur) is supported by the Institut Pasteur, the Collège de France, the French Government’s Investissement d’Avenir program, Laboratoires d’Excellence “Integrative Biology of Emerging Infectious Diseases” (ANR-10-LABX-62-IBEID) and “Milieu Intérieur” (ANR-10-LABX-69-01), the Fondation de France (no. 00106080), the FRM (Equipe FRM DEQ20180339214 team), and the ANR COVID-19-POPCELL (ANR-21-CO14-0003-01). A.Puj. is supported by ACCI20-759 CIBERER, EasiGenomics H2020 Marató TV3 COVID 2021-31-33, the HORIZON-HLTH-2021-ID: 101057100 (UNDINE), the Horizon 2020 program under grant no. 824110 (EasiGenomics grant no. COVID-19/PID12342), and the CERCA Program/Generalitat de Catalunya. The Canarian Health System sequencing hub was funded by the Instituto de Salud Carlos III (COV20_01333 and COV20_01334), the Spanish Ministry of Science and Innovation (RTC-2017-6471-1; AEI/FEDER, UE), Fundación MAPFRE Guanarteme (OA21/131), and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”). The CoV-Contact Cohort was funded by the French Ministry of Health and the European Commission (RECOVER project). Our studies are also funded by the Ministry of Health of the Czech Republic Conceptual Development of Research Organization (FNBr, 65269705) and ANID COVID0999 funding in Chile. G. Novelli and A. Novelli are supported by Regione Lazio (Research Group Projects 2020) No. A0375-2020-36663, GecoBiomark. A.M.P., M.L.D., and J.P.-T. are supported by the Inmungen-CoV2 project of CSIC. This work was supported in part by the Intramural Research Program of the NIAID, NIH. The research work of A.M.P, M.L.D., and J.P.-T. was funded by the European Commission –NextGenerationEU (Regulation EU 2020/2094), through CSIC’s Global Health Platform (PTI Salud Global). I.M. is a senior clinical investigator at FWO Vlaanderen supported by a VIB GC PID grant, by FWO grants G0B5120N (DADA2) and G0E8420N, and by the Jeffrey Modell Foundation. I.M. holds an ERC-StG MORE2ADA2 grant and is also supported by ERN-RITA. A.Y. is supported by fellowships from the European Academy of Dermatology and Venereology and the Swiss National Science Foundation and by an Early Career Award from the Thrasher Research Fund. Y.-H.C. is supported by an A*STAR International Fellowship (AIF). M.O. was supported by the David Rockefeller Graduate Program, the New York Hideyo Noguchi Memorial Society (HNMS), the Funai Foundation for Information Technology (FFIT), the Honjo International Scholarship Foundation (HISF), and the National Cancer Institute (NCI) F99 Award (F99CA274708). A.A.A. was supported by Ministerio de Ciencia Tecnología e Innovación MINCIENCIAS, Colombia (111584467551/CT 415-2020). D.L. is supported by a fellowship from the FRM for medical residents and fellows. E.H. received funding from the Bank of Montreal Chair of Pediatric Immunology, Foundation of CHU Sainte-Justine, CIHR grants PCC-466901 and MM1-181123, and a Canadian Pediatric Society IMPACT study. Q.P.-H. received funding from the European Union’s Horizon 2020 research and innovation program (ATAC, 101003650), the Swedish Research Council, and the Knut and Alice Wallenberg Foundation. Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, R01AI091707-10S1, and R01AI161444; a George Mason University Fast Grant; the G. Harold and Leila Y. Mathers Charitable Foundation; the Meyer Foundation; and the Bawd Foundation. R.P.L. is on the board of directors of both Roche and the Roche subsidiary Genentech. J.L.P. was supported by a Francois Wallace Monahan Postdoctoral Fellowship at the Rockefeller University and by a European Molecular Biology Organization Long-Term Fellowship (ALTF 380-2018)."}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642816","@type":"Researcher","foaf:name":[{"@value":"Dong, B"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642731","@type":"Researcher","foaf:name":[{"@value":"Le Pen, J"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642703","@type":"Researcher","foaf:name":[{"@value":"Yatim, A"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340642857","@type":"Researcher","foaf:name":[{"@value":"Ogishi, M"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340644012","@type":"Researcher","foaf:name":[{"@value":"Aquino, Y"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643602","@type":"Researcher","foaf:name":[{"@value":"Pescarmona, R"}]},{"@id":"https://cir.nii.ac.jp/crid/1893118016340643075","@type":"Researcher","foaf:name":[{"@value":"Rinchai, 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