{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360869854363171712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/epigenomes8020022"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2075-4655/8/2/22/pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Epigenetic Regulation of Neural Stem Cells in Developmental and Adult Stages"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The development of the nervous system is regulated by numerous intracellular molecules and cellular signals that interact temporally and spatially with the extracellular microenvironment. The three major cell types in the brain, i.e., neurons and two types of glial cells (astrocytes and oligodendrocytes), are generated from common multipotent neural stem cells (NSCs) throughout life. However, NSCs do not have this multipotentiality from the beginning. During cortical development, NSCs sequentially obtain abilities to differentiate into neurons and glial cells in response to combinations of spatiotemporally modulated cell-intrinsic epigenetic alterations and extrinsic factors. After the completion of brain development, a limited population of NSCs remains in the adult brain and continues to produce neurons (adult neurogenesis), thus contributing to learning and memory. Many biological aspects of brain development and adult neurogenesis are regulated by epigenetic changes via behavioral control of NSCs. Epigenetic dysregulation has also been implicated in the pathogenesis of various brain diseases. Here, we present recent advances in the epigenetic regulation of NSC behavior and its dysregulation in brain disorders.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380869854363171750","@type":"Researcher","foaf:name":[{"@value":"Shu Kunoh"}],"jpcoar:affiliationName":[{"@value":"Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854363171719","@type":"Researcher","foaf:name":[{"@value":"Hideyuki Nakashima"}],"jpcoar:affiliationName":[{"@value":"Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276178195200","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80302892"},{"@type":"NRID","@value":"1000080302892"},{"@type":"ORCID","@value":"0000-0001-5901-9628"},{"@type":"NRID","@value":"9000018475251"},{"@type":"NRID","@value":"9000258714131"},{"@type":"NRID","@value":"9000253552268"},{"@type":"NRID","@value":"9000391994796"},{"@type":"NRID","@value":"9000242703641"},{"@type":"NRID","@value":"9000018927450"},{"@type":"NRID","@value":"9000399814441"},{"@type":"NRID","@value":"9000317166602"},{"@type":"NRID","@value":"9000317166619"},{"@type":"NRID","@value":"9000392065365"},{"@type":"NRID","@value":"9000410151270"},{"@type":"NRID","@value":"9000399595369"},{"@type":"NRID","@value":"9000347069403"},{"@type":"NRID","@value":"9000017610726"},{"@type":"NRID","@value":"9000346921080"},{"@type":"NRID","@value":"9000019075581"},{"@type":"NRID","@value":"9000023352642"},{"@type":"NRID","@value":"9000316223291"},{"@type":"NRID","@value":"9000317166626"},{"@type":"NRID","@value":"9000317166606"},{"@type":"NRID","@value":"9000018215107"},{"@type":"NRID","@value":"9000002122077"},{"@type":"NRID","@value":"9000275834438"},{"@type":"NRID","@value":"9000018890635"},{"@type":"NRID","@value":"9000347224491"},{"@type":"NRID","@value":"9000253552269"},{"@type":"NRID","@value":"9000317166584"},{"@type":"NRID","@value":"9000283731557"},{"@type":"NRID","@value":"9000283729708"},{"@type":"NRID","@value":"9000253180573"},{"@type":"NRID","@value":"9000253552252"},{"@type":"NRID","@value":"9000375852316"},{"@type":"NRID","@value":"9000408426907"},{"@type":"NRID","@value":"9000391992802"},{"@type":"NRID","@value":"9000317166595"},{"@type":"NRID","@value":"9000253471015"},{"@type":"NRID","@value":"9000018385028"},{"@type":"NRID","@value":"9000317166572"},{"@type":"NRID","@value":"9000356479227"},{"@type":"NRID","@value":"9000356510491"},{"@type":"NRID","@value":"9000008824175"},{"@type":"NRID","@value":"9000255953276"},{"@type":"NRID","@value":"9000336374890"},{"@type":"NRID","@value":"9000341540941"},{"@type":"NRID","@value":"9000414742154"},{"@type":"NRID","@value":"9000255679758"},{"@type":"NRID","@value":"9000242349096"},{"@type":"NRID","@value":"9000317166633"},{"@type":"NRID","@value":"9000317166589"},{"@type":"NRID","@value":"9000253552253"},{"@type":"NRID","@value":"9000392068633"},{"@type":"NRID","@value":"9000018542980"},{"@type":"NRID","@value":"9000331448701"},{"@type":"NRID","@value":"9000283893764"},{"@type":"NRID","@value":"9000010183118"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kinichinakashima"}],"foaf:name":[{"@value":"Kinichi Nakashima"}],"jpcoar:affiliationName":[{"@value":"Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20754655"}],"prism:publicationName":[{"@value":"Epigenomes"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2024-06-04","prism:volume":"8","prism:number":"2","prism:startingPage":"22"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2075-4655/8/2/22/pdf"}],"createdAt":"2024-06-04","modifiedAt":"2025-10-10","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=neurogenesis","dc:title":"neurogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=epigenetics","dc:title":"epigenetics"},{"@id":"https://cir.nii.ac.jp/all?q=brain","dc:title":"brain"},{"@id":"https://cir.nii.ac.jp/all?q=Genetics","dc:title":"Genetics"},{"@id":"https://cir.nii.ac.jp/all?q=astrogenesis","dc:title":"astrogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Review","dc:title":"Review"},{"@id":"https://cir.nii.ac.jp/all?q=QH426-470","dc:title":"QH426-470"},{"@id":"https://cir.nii.ac.jp/all?q=development","dc:title":"development"},{"@id":"https://cir.nii.ac.jp/all?q=TP248.13-248.65","dc:title":"TP248.13-248.65"},{"@id":"https://cir.nii.ac.jp/all?q=neural%20stem%20cells","dc:title":"neural stem cells"},{"@id":"https://cir.nii.ac.jp/all?q=Biotechnology","dc:title":"Biotechnology"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040295802078324096","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23H00391"},{"@type":"JGN","@value":"JP23H00391"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00391/"}],"notation":[{"@language":"ja","@value":"脳老化と神経疾患に共通した脳機能低下に懸かる細胞間相互作用機序の統合的理解"},{"@language":"en","@value":"Integrated understanding of cell-cell interaction mechanisms underlying brain dysfunction common to brain aging and neurological disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1040296807938509312","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K18164"},{"@type":"JGN","@value":"JP23K18164"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18164/"}],"notation":[{"@language":"ja","@value":"脊髄損傷による遠位脳のニューロン新生低下と認知障害誘発機構の解明及び改善法の創発"},{"@language":"en","@value":"Elucidation of the mechanism underlying spinal cord injury-impaired neurogenesis and cognitive function in the brain and development of their therapeutic strategies"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202632093696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1050577309352893056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Epigenetic modulation of seizure-induced neurogenesis and cognitive decline"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215853138176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Activation of Neuronal Gene Expression by the JMJD3 Demethylase Is 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through Maintaining Adult Neural Stem Cell Identity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306911412408832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic signature and enhancer activity of the human APOE gene"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306912230038144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Targeting epigenetic modifications in Parkinson's disease therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306913372607488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>De novo</i>\n                    DNA methylation controls neuronal maturation during adult hippocampal neurogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306913645425664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetics in 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Report"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096031316736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096210434560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096303289856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096414027136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA methylation: roles in mammalian development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096492427264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576121931516160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Formation and integration of new neurons in the adult hippocampus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236957310080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Neuronal fate acquisition and specification: time for a change"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580239838569216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584343264620416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The specific role of histone deacetylase 2 in adult neurogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584344416883840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"QSER1 protects DNA methylation valleys from de novo methylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588384459392640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome-wide demethylation destabilizes CTG·CAG trinucleotide repeats in mammalian cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588384459448192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phf21b imprints the spatiotemporal epigenetic switch essential for neural stem cell differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588384459788672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588384459803776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Abnormalities of Neurogenesis in the R6/2 Mouse Model of Huntington's Disease Are Attributable to the<i>In Vivo</i>Microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588387237441408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic regulation of presenilin 1 and 2 in the cerebral cortex of mice during development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588387238309120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588387238316416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic Mechanisms in Stroke and Epilepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588389257894912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PRDM16 regulates a temporal transcriptional program to promote progression of cortical neural progenitors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640782467456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prdm3 and Prdm16 are H3K9me1 Methyltransferases Required for Mammalian Heterochromatin Integrity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567860275840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chromatin structure and the inheritance of epigenetic information"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568792825472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569029159808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569367045248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569499055360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal 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