{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360869854371333760.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s44319-024-00197-4"}},{"identifier":{"@type":"URI","@value":"https://www.embopress.org/doi/epdf/10.1038/s44319-024-00197-4"}},{"identifier":{"@type":"URI","@value":"https://www.embopress.org/doi/full/10.1038/s44319-024-00197-4"}},{"identifier":{"@type":"DOI","@value":"10.1101/2023.09.26.559625"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Skeletal muscle regeneration involves a signaling network that regulates the proliferation, differentiation, and fusion of muscle precursor cells to injured myofibers. IRE1α, one of the arms of the unfolded protein response, regulates cellular proteostasis in response to ER stress. Here, we demonstrate that inducible deletion of IRE1α in satellite cells of mice impairs skeletal muscle regeneration through inhibiting myoblast fusion. Knockdown of IRE1α or its downstream target, X-box protein 1 (XBP1), also inhibits myoblast fusion during myogenesis. Transcriptome analysis revealed that knockdown of IRE1α or XBP1 dysregulates the gene expression of molecules involved in myoblast fusion. The IRE1α-XBP1 axis mediates the gene expression of multiple profusion molecules, including myomaker (\n                    <jats:italic>Mymk</jats:italic>\n                    ). Spliced XBP1 (sXBP1) transcription factor binds to the promoter of\n                    <jats:italic>Mymk</jats:italic>\n                    gene during myogenesis. Overexpression of myomaker in IRE1α-knockdown cultures rescues fusion defects. Inducible deletion of IRE1α in satellite cells also inhibits myoblast fusion and myofiber hypertrophy in response to functional overload. Collectively, our study demonstrates that IRE1α promotes myoblast fusion through sXBP1-mediated up-regulation of the gene expression of multiple profusion molecules, including myomaker.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380869854371333650","@type":"Researcher","foaf:name":[{"@value":"Aniket S Joshi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854371333764","@type":"Researcher","foaf:name":[{"@value":"Meiricris Tomaz da Silva"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854371333760","@type":"Researcher","foaf:name":[{"@value":"Anirban Roy"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854371333651","@type":"Researcher","foaf:name":[{"@value":"Tatiana E Koike"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854371333638","@type":"Researcher","foaf:name":[{"@value":"Mingfu Wu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854371333634","@type":"Researcher","foaf:name":[{"@value":"Micah B Castillo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854371333648","@type":"Researcher","foaf:name":[{"@value":"Preethi H Gunaratne"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854371333510","@type":"Researcher","foaf:name":[{"@value":"Yu Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854371333513","@type":"Researcher","foaf:name":[{"@value":"Takao Iwawaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854371333643","@type":"Researcher","foaf:name":[{"@value":"Ashok Kumar"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14693178"}],"prism:publicationName":[{"@value":"EMBO Reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2024-07-09","prism:volume":"25","prism:number":"8","prism:startingPage":"3627","prism:endingPage":"3650"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.embopress.org/doi/epdf/10.1038/s44319-024-00197-4"},{"@id":"https://www.embopress.org/doi/full/10.1038/s44319-024-00197-4"}],"createdAt":"2024-07-09","modifiedAt":"2025-12-06","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040018351906292736","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24K02833"},{"@type":"JGN","@value":"JP24K02833"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02833/"}],"notation":[{"@language":"ja","@value":"疲労時に活性化する細胞ストレス応答の生体保護的な役割を解明するために"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050304183897105408","@type":"Article","resourceType":"学術雑誌論文(journal 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