{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360869854373368576.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1101/2025.03.05.641622"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1101/2025.03.05.641622"}}],"resourceType":"preprint","dc:title":[{"@value":"Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                <jats:p>\n                  Linker histone H1, the most abundant chromatin protein, condenses chromatin, modulates DNA transactions such as transcription and DNA replication/repair, and participates in differentiation, development and tumorigenesis. While recent studies indicate that nucleosomes are clustered as condensed chromatin domains in higher eukaryotic cells, how histone H1 mechanically condenses chromatin remains unclear. Here, using a combination of direct visualization of single-H1 molecules in living human cells and multiscale molecular dynamics simulations, we demonstrate that the majority of H1 behaves like a liquid inside chromatin domains, rather than binding stably to nucleosomes as suggested by the traditional model. H1 functions as a liquid-like “glue”, mediating dynamic multivalent electrostatic interactions between nucleosomes within chromatin domains. Consistently, rapid-depletion of H1.2 leads to decondensed chromatin domains both in cells and\n                  <jats:italic>in silico</jats:italic>\n                  . Our findings suggest that the H1 “glue” condenses chromatin domains while keeping them fluid and accessible, thereby supporting essential DNA transactions.\n                </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380869854373368707","@type":"Researcher","foaf:name":[{"@value":"Masa A. Shimazoe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854373368578","@type":"Researcher","foaf:name":[{"@value":"Jan Huertas"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854373368710","@type":"Researcher","foaf:name":[{"@value":"Charles Phillips"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854373368704","@type":"Researcher","foaf:name":[{"@value":"Satoru Ide"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854373368708","@type":"Researcher","foaf:name":[{"@value":"Sachiko Tamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854373368709","@type":"Researcher","foaf:name":[{"@value":"Stephen Farr"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854373368577","@type":"Researcher","foaf:name":[{"@value":"S. S. Ashwin"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854373368706","@type":"Researcher","foaf:name":[{"@value":"Masaki Sasai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854373368705","@type":"Researcher","foaf:name":[{"@value":"Rosana Collepardo-Guevara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869854373368576","@type":"Researcher","foaf:name":[{"@value":"Kazuhiro Maeshima"}]}],"publication":{"dc:publisher":[{"@value":"openRxiv"}],"prism:publicationDate":"2025-03-06"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"https://syndication.highwire.org/content/doi/10.1101/2025.03.05.641622"}],"createdAt":"2025-03-07","modifiedAt":"2026-01-15","project":[{"@id":"https://cir.nii.ac.jp/crid/1040862931496983552","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24KJ1161"},{"@type":"JGN","@value":"JP24KJ1161"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24KJ1161/"}],"notation":[{"@language":"ja","@value":"生細胞におけるリンカーヒストンH1によるクロマチン凝縮メカニズムの解明"},{"@language":"en","@value":"How linker histone H1 condenses chromatin in living cell?"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282810831344000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Transient Rise in 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