{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360869855563067904.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/glycob/cwae036"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/glycob/advance-article-pdf/doi/10.1093/glycob/cwae036/57882524/cwae036.pdf"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/glycob/article-pdf/34/7/cwae036/57986993/cwae036.pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Limited impact of cancer-derived gangliosides on anti-tumor immunity in colorectal cancer"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:p>Aberrant glycosylation is a key mechanism employed by cancer cells to evade immune surveillance, induce angiogenesis and metastasis, among other hallmarks of cancer. Sialic acids, distinctive terminal glycan structures located on glycoproteins or glycolipids, are prominently upregulated across various tumor types, including colorectal cancer (CRC). Sialylated glycans modulate anti-tumor immune responses through their interactions with Siglecs, a family of glycan-binding receptors with specificity for sialic acid-containing glycoconjugates, often resulting in immunosuppression. In this paper, we investigated the immunomodulatory function of ST3Gal5, a sialyltransferase that catalyzes the addition of α2-3 sialic acids to glycosphingolipids, since lower expression of ST3Gal5 is associated with better survival of CRC patients. We employed CRISPR/Cas9 to knock out the ST3Gal5 gene in two murine CRC cell lines MC38 and CT26. Glycomics analysis confirmed the removal of sialic acids on glycolipids, with no discernible impact on glycoprotein sialylation. Although knocking out ST3Gal5 in both cell lines did not affect in vivo tumor growth, we observed enhanced levels of regulatory T cells in CT26 tumors lacking ST3Gal5. Moreover, we demonstrate that the absence of ST3Gal5 affected size and blood vessel density only in MC38 tumors. In summary, we ascertain that sialylation of glycosphingolipids has a limited influence on the anti-tumor immune response in CRC, despite detecting alterations in the tumor microenvironment, possibly due to a shift in ganglioside abundance.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380869855563067791","@type":"Researcher","foaf:name":[{"@value":"Irene van der Haar Àvila"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Cell Biology and Immunology, Amsterdam UMC location Vrije Universiteit Amsterdam , de Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands"},{"@value":"Cancer Center Amsterdam, Cancer Biology and Immunology , Amsterdam, the Netherlands"},{"@value":"Cancer Immunology, Amterdam institute for Immunology and Infectious Diseases , Amsterdam, the Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869855563067785","@type":"Researcher","foaf:name":[{"@value":"Tao Zhang"}],"jpcoar:affiliationName":[{"@value":"Center for Proteomics and Metabolomics, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869855563067922","@type":"Researcher","foaf:name":[{"@value":"Victor Lorrain"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Cell Biology and Immunology, Amsterdam UMC location Vrije Universiteit Amsterdam , de Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869855563067797","@type":"Researcher","foaf:name":[{"@value":"Florance de Bruin"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Cell Biology and Immunology, Amsterdam UMC location Vrije Universiteit Amsterdam , de Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869855563067939","@type":"Researcher","foaf:name":[{"@value":"Tianne Spreij"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Cell Biology and Immunology, Amsterdam UMC location Vrije Universiteit Amsterdam , de Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276177449216","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70514933"},{"@type":"NRID","@value":"1000070514933"},{"@type":"NRID","@value":"9000006585971"},{"@type":"NRID","@value":"9000253169423"},{"@type":"NRID","@value":"9000257807122"},{"@type":"NRID","@value":"9000364953334"},{"@type":"NRID","@value":"9000021870356"},{"@type":"NRID","@value":"9000021999955"},{"@type":"NRID","@value":"9000254406824"},{"@type":"NRID","@value":"9000398022715"},{"@type":"NRID","@value":"9000018920606"},{"@type":"NRID","@value":"9000364952683"},{"@type":"NRID","@value":"9000408609665"},{"@type":"NRID","@value":"9000021193188"},{"@type":"NRID","@value":"9000257814114"},{"@type":"NRID","@value":"9000409378123"},{"@type":"NRID","@value":"9000021932150"},{"@type":"NRID","@value":"9000408608410"},{"@type":"NRID","@value":"9000018537664"},{"@type":"NRID","@value":"9000018183593"},{"@type":"NRID","@value":"9000364951132"},{"@type":"NRID","@value":"9000347362423"},{"@type":"NRID","@value":"9000391605333"},{"@type":"NRID","@value":"9000405616089"},{"@type":"NRID","@value":"9000257971071"},{"@type":"NRID","@value":"9000020306775"},{"@type":"NRID","@value":"9000391973152"},{"@type":"NRID","@value":"9000011148165"},{"@type":"NRID","@value":"9000408609664"},{"@type":"NRID","@value":"9000405616101"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/nhito777"}],"foaf:name":[{"@value":"Hitoshi Nakayama"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Health Care and Nursing , Laboratory of Biochemistry, , 2-5-1 Takasu Urayasu-shi, Chiba, 279-0023, Japan"},{"@value":"Juntendo University , Laboratory of Biochemistry, , 2-5-1 Takasu Urayasu-shi, Chiba, 279-0023, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869855563067927","@type":"Researcher","foaf:name":[{"@value":"Kazuhisa Iwabuchi"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Health Care and Nursing , Laboratory of Biochemistry, , 2-5-1 Takasu Urayasu-shi, Chiba, 279-0023, Japan"},{"@value":"Juntendo University , Laboratory of Biochemistry, , 2-5-1 Takasu Urayasu-shi, Chiba, 279-0023, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869855563067817","@type":"Researcher","foaf:name":[{"@value":"Juan J García-Vallejo"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Cell Biology and Immunology, Amsterdam UMC location Vrije Universiteit Amsterdam , de Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands"},{"@value":"Cancer Center Amsterdam, Cancer Biology and Immunology , Amsterdam, the Netherlands"},{"@value":"Cancer Immunology, Amterdam institute for Immunology and Infectious Diseases , Amsterdam, the Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869855563067809","@type":"Researcher","foaf:name":[{"@value":"Manfred Wuhrer"}],"jpcoar:affiliationName":[{"@value":"Center for Proteomics and Metabolomics, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869855563067923","@type":"Researcher","foaf:name":[{"@value":"Yvette van Kooyk"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Cell Biology and Immunology, Amsterdam UMC location Vrije Universiteit Amsterdam , de Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands"},{"@value":"Cancer Center Amsterdam, Cancer Biology and Immunology , Amsterdam, the Netherlands"},{"@value":"Cancer Immunology, Amterdam institute for Immunology and Infectious Diseases , Amsterdam, the Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869855563067798","@type":"Researcher","foaf:name":[{"@value":"Sandra J van Vliet"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Cell Biology and Immunology, Amsterdam UMC location Vrije Universiteit Amsterdam , de Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands"},{"@value":"Cancer Center Amsterdam, Cancer Biology and Immunology , Amsterdam, the Netherlands"},{"@value":"Cancer Immunology, Amterdam institute for Immunology and Infectious Diseases , Amsterdam, the Netherlands"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14602423"}],"prism:publicationName":[{"@value":"Glycobiology"}],"dc:publisher":[{"@value":"Oxford University Press 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CD70"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621465729664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621513335552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Siglecs and their roles in the immune system"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294646777912064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ganglioside-exposed dendritic cells inhibit T-cell effector function by promoting regulatory cell activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298343139238528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298762221104384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Total loss of GM3 synthase activity by a normally processed enzyme in a novel variant and in all ST3GAL5 variants reported to cause a distinct congenital disorder of glycosylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306908989412608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Current state-of-the-art on ganglioside-mediated immune modulation in the tumor microenvironment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306910302667904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential O- and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells With Opposite Morphology and Metastatic Behavior"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306910693849216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306910693951360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mechanisms of Ganglioside Inhibition of APC Function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306912244183680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Siglec receptors as new immune checkpoints in cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184551941248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ganglioside GM3 is essential for the structural integrity and function of cochlear hair 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patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096048519296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580237017930496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588388240955008","@type":"Article","resourceType":"preprint","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The transcriptional landscape of glycosylation-related genes in cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657643624704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659521394432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569373904256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569588992256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The tumour glyco-code as a novel immune checkpoint for immunotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569787241088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The immune contexture in cancer prognosis and treatment"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570693719040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glycosylation in cancer: mechanisms and clinical implications"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857596154782592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell–Mediated Tumor Immunity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857597581824384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Deficiency of ganglioside biosynthesis in metastatic human melanoma cells: relevance of CMP‐NeuAc: LacCer α2‐3 sialyltransferase (GM3 synthase)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360862719871350016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Negative ion graphitised carbon nano‐liquid chromatography/mass spectrometry increases sensitivity for glycoprotein oligosaccharide analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865821073531136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Downregulation of ST3GAL5 is associated with muscle invasion, high grade and a poor prognosis in patients with bladder cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869859058699264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Combined Blockade of GARP:TGF-β1 and PD-1 Increases Infiltration of T Cells and Density of Pericyte-Covered GARP+ Blood Vessels in Mouse MC38 Tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869862177714304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137044761886336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045941808768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glycosylation Characteristics of Colorectal Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518671453440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biological Functions and Analytical Strategies of Sialic Acids in Tumor"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520723515008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Letter to the Glyco-Forum: Effective glycoanalysis with Maackia amurensis lectins requires a clear understanding of their binding specificities"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520823545600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993694018816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Silencing of GM3 synthase suppresses lung metastasis of murine breast cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993747997312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"GlycoMod - A software tool for determining glycosylation compositions from mass 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