{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360869856053542016.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41416-024-02691-x"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41416-024-02691-x.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41416-024-02691-x"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:sec>\n                <jats:title>Background</jats:title>\n                <jats:p>Cancer cells in severely hypoxic regions have been reported to invade towards tumour blood vessels after surviving radiotherapy in a postirradiation reoxygenation- and hypoxia-inducible factor (HIF)-dependent manner and cause recurrence. However, how HIF induces invasiveness of irradiated and reoxygenated cancer cells remains unclear.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Methods</jats:title>\n                <jats:p>Here, we identified human minor histocompatibility antigen 1 (HMHA1), which has been suggested to function in cytoskeleton dynamics and cellular motility, as a responsible factor and elucidated its mechanism of action using molecular and cellular biology techniques.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Results</jats:title>\n                <jats:p>HMHA1 expression was found to be induced at the transcription initiation level in a HIF-dependent manner under hypoxia. Boyden chamber invasion assay revealed that the induction of HMHA1 expression is required for the increase in invasion of hypoxic cancer cells. Reoxygenation treatment after ionising radiation in vitro that mimics dynamic changes of a microenvironment in hypoxic regions of tumour tissues after radiation therapy further enhanced HMHA1 expression and invasive potential of HMHA1 wildtype cancer cells in ROS- and HIF-dependent manners, but not of HMHA1 knockout cells.</jats:p>\n              </jats:sec><jats:sec>\n                <jats:title>Conclusion</jats:title>\n                <jats:p>These results together provide insights into a potential molecular mechanism of the acquisition of invasiveness by hypoxic cancer cells after radiotherapy <jats:italic>via</jats:italic> the activation of the ROS/HIF/HMHA1 axis.</jats:p>\n              </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380869856053542061","@type":"Researcher","foaf:name":[{"@value":"Peter W. T. Lee"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869856053542045","@type":"Researcher","foaf:name":[{"@value":"Tatsuya Suwa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869856053542060","@type":"Researcher","foaf:name":[{"@value":"Minoru Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869856053542030","@type":"Researcher","foaf:name":[{"@value":"Hui Yang"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869856053542019","@type":"Researcher","foaf:name":[{"@value":"Lina R. Koseki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869856053542051","@type":"Researcher","foaf:name":[{"@value":"Satoshi Takeuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869856053542042","@type":"Researcher","foaf:name":[{"@value":"Christalle C. T. Chow"}]},{"@id":"https://cir.nii.ac.jp/crid/1380869856053542040","@type":"Researcher","foaf:name":[{"@value":"Takaaki Yasuhara"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326213802240","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80362531"},{"@type":"NRID","@value":"1000080362531"},{"@type":"ORCID","@value":"0000-0001-7507-3173"},{"@type":"NRID","@value":"9000258722490"},{"@type":"NRID","@value":"9000237870121"},{"@type":"NRID","@value":"9000347050303"},{"@type":"NRID","@value":"9000010973267"},{"@type":"NRID","@value":"9000024070040"},{"@type":"NRID","@value":"9000414941474"},{"@type":"NRID","@value":"9000408426627"},{"@type":"NRID","@value":"9000016383032"},{"@type":"NRID","@value":"9000256029279"},{"@type":"NRID","@value":"9000018960337"},{"@type":"NRID","@value":"9000347667778"},{"@type":"NRID","@value":"9000015284037"},{"@type":"NRID","@value":"9000257910159"},{"@type":"NRID","@value":"9000387919453"},{"@type":"NRID","@value":"9000411819062"},{"@type":"NRID","@value":"9000242109318"},{"@type":"NRID","@value":"9000024333844"},{"@type":"NRID","@value":"9000237870939"},{"@type":"NRID","@value":"9000398992814"},{"@type":"NRID","@value":"9000308368961"},{"@type":"NRID","@value":"9000240537975"},{"@type":"NRID","@value":"9000293528157"},{"@type":"NRID","@value":"9000327101160"},{"@type":"NRID","@value":"9000018767930"},{"@type":"NRID","@value":"9000364836115"},{"@type":"NRID","@value":"9000323291302"},{"@type":"NRID","@value":"9000413738879"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000008435"}],"foaf:name":[{"@value":"Hiroshi Harada"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00070920"},{"@type":"EISSN","@value":"15321827"}],"prism:publicationName":[{"@value":"British Journal of Cancer"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2024-05-13","prism:volume":"131","prism:number":"1","prism:startingPage":"37","prism:endingPage":"48"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41416-024-02691-x.pdf"},{"@id":"https://www.nature.com/articles/s41416-024-02691-x"}],"createdAt":"2024-05-13","modifiedAt":"2024-07-08","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040018351904422912","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K27546"},{"@type":"JGN","@value":"JP23K27546"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27546/"}],"notation":[{"@language":"ja","@value":"放射線抵抗性の腫瘍内低酸素分画をモニターする血中バイオマーカーの開発"}]},{"@id":"https://cir.nii.ac.jp/crid/1040858906219838592","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23KJ1316"},{"@type":"JGN","@value":"JP23KJ1316"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23KJ1316/"}],"notation":[{"@language":"ja","@value":"IDH3αの機能解析及びその欠失に起因する疾患、表現型の解析"},{"@language":"en","@value":"Analyses of the role of IDH3a and disorders and phenotype(s) cause by its deficiency"}]},{"@id":"https://cir.nii.ac.jp/crid/1040859757891975424","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"23K18274"},{"@type":"JGN","@value":"JP23K18274"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18274/"}],"notation":[{"@language":"ja","@value":"がんの放射線治療抵抗性を担うHIFシグナルが活性化しているストローマ亜細胞の同定"},{"@language":"en","@value":"Identification of stromal subcellular population which exhiites active HIF signaling and is responsible for radioresistance of cancer"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335843686912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor 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